ISSN:
1432-0533
Keywords:
Key words Hodgkin’s lymphoma
;
Primary central ¶nervous system lymphoma
;
Immunosuppression
;
Epstein-Barr virus
;
Immunoglobulin rearrangement
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A 66-year-old woman treated for ocular myasthenia gravis with azathioprine for 12 years presented with a left fronto-parietal mass. Histology revealed primary Hodgkin’s lymphoma of the central nervous system with CD30, Epstein-Barr virus (EBV) latent membrane protein and CD20-positive, CD45 (LCA)-negative Reed-Sternberg cells surrounded by T cells. Moreover, EBV-encoded RNA-1 (EBER-1) sequences and a monoclonal rearrangement of the immunoglobulin heavy chain CDR2 locus were detected.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004010051185
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