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  • Tuberculosis  (4)
  • Elderly  (2)
  • Fluoride poisoning  (2)
  • Inorganic Chemistry  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Mitoxantrone and cytosine arabinoside as treatment for acute myeloblastic leukemia in older patients (1995)
    Springer
    Annals of hematology 71 (1995), S. 35-39 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Acute myeloid leukemia ; Cytosine arabinoside ; Elderly ; Mitoxantrone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The majority of patients with acute myeloid leukemia (AML) are elderly, and their response to chemotherapy is poorer than that of younger patients. The combination of mitoxantrone (MTN) and cytosine arabinoside (Ara-C) is a possible alternative to an anthracycline/Ara-C combination for the treatment of AML in these patients. Of 52 older patients (〉 59 years) referred over a 3.5-year period, 33 patients (age range 60–78 years, median 67 years) received MTN and Ara-C as therapy for newly diagnosed AML. MTN was administered at a dose of 12 mg/m2/day, intravenously, for 3 days (23 patients), or 10 mg/m2/day for 5 days (10 patients), and Ara-C at a dose of 100 mg/m2 twice daily, intravenously, for 7 days. Complete remission (CR) was achieved in 16/33 patients (48%). The median remission duration was 6 months (range 1–37 months). The median survival was 14 months for those who achieved CR compared with 9 months for those with resistant disease. Two patients remain in first CR after 13 and 37 months, but three patients died whilst receiving consolidation therapy. In selected elderly patients with AML, the combination of MTN and Ara-C provides an acceptable alternative to an anthracycline/ Ara-C regimen, with a higher CR rate than historical controls. However, the CR rate and remission duration remain low compared with those of younger patients, supporting the need to investigate new approaches to treatment in this population.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01696230
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  • 2
    Digitale Medien
    Digitale Medien
    Mitoxantrone and cytosine arabinoside as treatment for acute myeloblastic leukemia in older patients (1995)
    Springer
    Annals of hematology 71 (1995), S. 35-39 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Key words Acute myeloid leukemia ; Cytosine arabinoside ; Elderly ; Mitoxantrone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  The majority of patients with acute myeloid leukemia (AML) are elderly, and their response to chemotherapy is poorer than that of younger patients. The combination of mitoxantrone (MTN) and cytosine arabinoside (Ara-C) is a possible alternative to an anthracycline/Ara-C combination for the treatment of AML in these patients. Of 52 older patients (〉59 years) referred over a 3.5-year period, 33 patients (age range 60–78 years, median 67 years) received MTN and Ara-C as therapy for newly diagnosed AML. MTN was administered at a dose of 12 mg/m2/day, intravenously, for 3 days (23 patients), or 10 mg/m2/day for 5 days (10 patients), and Ara-C at a dose of 100 mg/m2 twice daily, intravenously, for 7 days. Complete remission (CR) was achieved in 16/33 patients (48%). The median remission duration was 6 months (range 1–37 months). The median survival was 14 months for those who achieved CR compared with 9 months for those with resistant disease. Two patients remain in first CR after 13 and 37 months, but three patients died whilst receiving consolidation therapy. In selected elderly patients with AML, the combination of MTN and Ara-C provides an acceptable alternative to an anthracycline/ Ara-C regimen, with a higher CR rate than historical controls. However, the CR rate and remission duration remain low compared with those of younger patients, supporting the need to investigate new approaches to treatment in this population.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01696230
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  • 3
    Digitale Medien
    Digitale Medien
    MRI in intraspinal tuberculosis (1994)
    Springer
    Neuroradiology 36 (1994), S. 39-43 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Spine ; Spinal cord ; Tuberculosis ; MRI
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We studied 20 patients with intraspinal tuberculosis (TB), to characterise the MRI features of tuberculous meningitis and myelitis. MRI leptomeningitis and intramedullary involvement in 11 patients, intramedullary lesions alone in 5, leptomeningitis alone in 2, and isolated extradural disease in 2. TB leptomeningitis was characterised by loculation of the cerebrospinal fluid (CSF), nerve root thickening and clumping (seen only in the lumbar region) or complete obliteration of the subarachnoid space on unenhanced images. Gd-DTPA-enhanced images proved useful in 6 cases, revealing linear enhancement of the surface of the spinal cord and nerve roots or plaque-like enhancement of the dura-arachnoid mater complex. Intramedullary lesions included tuberculomas (8), cord oedema (5) and cavitation (3). In seven cases of intramedullary tuberculoma multiple lesions with skip areas were seen, without significant cord swelling. One patient had an isolated lesion in the conus medullaris. The lesions were iso- or hypointense on T1-weighted images, iso-, hypo- or hyperintense on T2-weighted images and showed rim or nodular enhancement with contrast medium.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00599194
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  • 4
    Digitale Medien
    Digitale Medien
    Compressive myelopathy in fluorosis: MRI (1996)
    Springer
    Neuroradiology 38 (1996), S. 338-342 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Magnetic resonance imaging ; Fluoride poisoning ; Ligaments ; Spinal cord compression
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We examined four patients with fluorosis, presenting with compressive myelopathy, by MRI, using spin-echo and fast low-angle shot sequences. Cord compression due to ossification of the posterior longitudinal ligament (PLL) and ligamentum flavum (LF) was demonstrated in one and ossification of only the LF in one. Marrow signal was observed in the PLL and LF in all the patients on all pulse sequences. In patients with compressive myelopathy secondary to ossification of PLL and/or LF, fluorosis should be considered as a possible cuase, especially in endemic regions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00596584
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  • 5
    Digitale Medien
    Digitale Medien
    Compressive myelopathy in fluorosis: MRI (1996)
    Springer
    Neuroradiology 38 (1996), S. 338-342 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Key words Magnetic resonance imaging ; Fluoride poisoning ; Ligaments ; Spinal cord compression
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We examined four patients with fluorosis, presenting with compressive myelopathy, by MRI, using spin-echo and fast low-angle shot sequences. Cord compression due to ossification of the posterior longitudinal ligament (PLL) and ligamentum flavum (LF) was demonstrated in one and ossification of only the LF in one. Marrow signal was observed in the PLL and LF in all the patients on all pulse sequences. In patients with compressive myelopathy secondary to ossification of PLL and/or LF, fluorosis should be considered as a possible cause, especially in endemic regions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00596584
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  • 6
    Digitale Medien
    Digitale Medien
    Problems in distinguishing spinal tuberculosis from neoplasia on MRI (1996)
    Springer
    Neuroradiology 38 (1996), S. S97 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Key words Spine ; infections ; Spine ; neoplasms ; Tuberculosis ; Computed tomography ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We reviewed MRI studies of 60 patients presenting with extradural compressive myeloradiculopathy secondary to vertebral disease to assess the imaging features which may help in differentiating tuberculous from neoplastic disease. Spin-echo T1-, proton density- and T2-weighted images were available for all patients and fast low-angle shot images with a low flip angle for 21 patients. Contrast-enhanced images were available for 28 patients. There were 41 patients with tuberculosis and 19 patients with neoplastic disease (metastases 11, lymphoma 6, plasmacytoma 1, and giant cell tumour 1). Discovertebral disease with or without involvement of the posterior arch was a feature not only of tuberculous spondylitis (30 patients) but also of metastases (6). The remaining 11 patients with tuberculosis had “atypical” involvement (vertebral body with or without posterior arch in 8 and posterior arch alone in 3) described as typical of neoplasms. This “typical” involvement was seen in metastases (5), lymphoma (6) and the 2 primary bone tumours. The presence of an abscess helped in differentiating tuberculosis from neoplasia in 22 of the 41 patients with tuberculosis and was absent in all with neoplasms. The presence of bone fragments in 16 patients (8 with and 8 without an abscess) was found to be specific for tuberculosis. In the absence of an abscess or bone fragments, image-guided biopsy is essential to establish the diagnosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002340050930
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  • 7
    Digitale Medien
    Digitale Medien
    Problems in distinguishing spinal tuberculosis from neoplasia on MRI (1996)
    Springer
    Neuroradiology 38 (1996), S. S97 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Spine, infections ; Spine, neoplasms ; Tuberculosis ; Computed tomography ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We reviewed MRI studies of 60 patients presenting with extradural compressive myeloradiculopathy secondary to vertebral disease to assess the imaging features which may help in differentiating tuberculous from neoplastic disease. Spinecho T1-, proton density- and T2-weighted images were available for all patients and fast low-angle shot images with a low flip angle for 21 patients. Contrast-enhanced images were available for 28 patients. There were 41 patients with tuberculosis and 19 patients with neoplastic disease (metastases 11, lymphoma 6, plasmacytoma 1, and giant cell tumour 1). Discovertebral disease with or without involvement of the posterior arch was a feature not only of tuberculous spondylitis (30 patients) but also of metastases (6). The remaining 11 patients with tuberculosis had “atypical” involvement (vertebral body with or without posterior arch in 8 and posterior arch alone in 3) described as typical of neoplasms. This “atypical” involvement was seen in metastases (5), lymphoma (6) and the 2 primary bone tumours. The presence of an abscess helped in differentiating tuberculosis from neoplasia in 22 of the 41 patients with tuberculosis and was absent in all with neoplasms. The presence of bone fragments in 16 patients (8 with and 8 without an abscess) was found to be specific for tuberculosis. In the absence of an abscess or bone fragments, image-guided biopsy is essential to establish the diagnosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02278131
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  • 8
    Digitale Medien
    Digitale Medien
    MRI of the brain in patients with miliary pulmonary tuberculosis without symptoms or signs of central nervous system involvement (1997)
    Springer
    Neuroradiology 39 (1997), S. 699-704 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Key words Magnetic resonance imaging ; Brain ; tuberculoma ; Tuberculosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract MRI was performed on patients with miliary pulmonary tuberculosis to look for brain involvement and to study the features sequentially, during treatment. We studied seven patients with typical radiographic tuberculosis, and no symptoms or signs of central nervous system involvement. Conventional spin-echo (SE) imaging, including contrast enhanced images, was performed in all cases. All patients showed brain involvement: four patients showed lesions mainly less than 3 mm in diameter, better seen on contrast-enhanced images. These patients showed oedema around the lesions after 2 months of treatment, with subsequent regression on follow-up. The remaining three patients had multiple lesions, 3 mm or more in diameter, which showed a gradual decrease on follow-up. We conclude that the brain may commonly be involved in miliary pulmonary tuberculosis. The response to treatment depends on the stage of the granuloma and shows a definite pattern of healing on follow-up.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002340050489
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  • 9
    Digitale Medien
    Digitale Medien
    Chemistry of Trivalent Niobium (1973)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 398 (1973), S. 312-316 
    Details
    ISSN: 0044-2313
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Chemie des dreiwertigen Niobs.Die stabile Verbindung KNb(SO4 · 4 H2O mit der Oxydationsstufe Nb3+ ist rein dargestellt und durch ihre chemischen Eigenschaften, UV-, optisches und IR-Spektrum sowie auch polarographisch charakterisiert worden.
    Notizen: A stable compound of lower valent niobium viz. KKb(SO4)2 · 4 H2O in which Nb is in +3 oxidation state has been isolated pure. It has been characterised by its chemical properties, UV, visible and i.r. spectral studies and also by polarographic investigations.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/zaac.19733980311
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  • 10
    Digitale Medien
    Digitale Medien
    Determination and comparison of the stability constants of some bivalent ion complexes of 5,7-dichloro-, 5,7-dibromo-, and 5,7-dinitro-8-Hydroxyquinoline and their N-oxides (1971)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 379 (1971), S. 312-319 
    Details
    ISSN: 0044-2313
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Die Stabilitätskonstanten der Komplexe von Mn++, Fe++, Co++, Ni++, Cu++, Zn++, Cd++ und UO++2 mit 5, 7-Dichlor-, 5, 7-Dibrom- und 5, 7-Dinitro-8-hydroxychinolin und der entsprechenden N-Oxide sind in Dioxan/Wasser-Gemischen (75/25) bei 35°C in Gegenwart von 0,20 m Natriumperchlorat durch Titration nach Irving und Rossotti bestimmt worden. Eine mögliche Erklärung für die beobachtete Abhängigkeit der Stabilitätskonstanten der Komplexe bei Variation des Liganden und andererseits bei Variation des Metalls wird vorgeschlagen.
    Notizen: The stability constants of complexes of Mn++, Fe++, Co++, Ni++, Cu++, Zn++, Cd++ and UO++2 with 5,7-dichloro-, 5,7-dibromo- and 5,7-dinitro-8-hydroxyquinoline and their corresponding N-oxides have been determined in 75 + 25 v/v dioxan + water medium at 35°C in presence of 0.20 M sodium perchlorate by pH-titration technique as given by IRVING and Rossotti. A possible explanation for the observed orders of the stability constants of the metal complex with the different ligands, and of the complexes of a particular ligand with different metal ions is also proposed.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/zaac.19713790312
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