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  • Electron microscopy  (2)
  • Paired helical filaments  (2)
  • Key words Membranous nephropathy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Characterization of a shared epitope in cortical Lewy body fibrils and Alzheimer paired helical filaments (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 1-6 
    Details
    ISSN: 1432-0533
    Keywords: Lewy body ; Neurofilament ; Alzheimer's disease ; Paired helical filaments ; Diffuse Lewy body disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The straight fibrils of the Lewy body contain an epitope related to phosphorylation of the KSPV motif common to the C termini of the 200- and 170-kDa neurofilament subunits and τ. To further characterize this phosphorylated neurofilament/τ epitope in Lewy bodies and to analyze the constituents of isolated Lewy bodies we used a combined biochemical and immunochemical approach. In formalin-fixed paraffin-embedded tissue cortical Lewy bodies were labelled by monoclonal antibodies directed to phosphorylation-dependent KSPV epitopes in the sequences of neurofilament and phosphorylation-independent epitopes. Immunoblotting of solubilized Lewy body fibrils with the same antibodies which stained Lewy bodies in tissue sections revealed that the immunoreactive Lewy body proteins were phosphorylated neurofilament subunits. An antibody to the 68-kDa neurofilament subunit labelled Lewy bodies and Lewy body protein at 50–68 kDa. We conclude that the shared phosphorylated epitope in Lewy body fibrils and paired helical filaments is related to the common KSPV sequence in neurofilament and τ, and that all three neurofilament subunits are present in the Lewy body. This result indicates that although Lewy bodies and neurofibrillary tangles share epitopes they are comprised of distinct structural subunits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294352
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Alzheimer paired helical filaments: a comparison with the twisted ribbon model (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 194-197 
    Details
    ISSN: 1432-0533
    Keywords: Key words Alzheimer's disease ; Paired helical ; filaments ; Electron microscopy ; Tau
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate if Alzheimer paired helical filaments (PHF) closely resemble twisted ribbons, as indicated by recent high-resolution ultrastructural studies, we compared physical models of twisted ribbons with electron microscopic images of PHF. Uranyl-acetate-stained, isolated PHF with one or two helical turns were compared with scale models of twisted ribbons with one and two helical turns rotated at different angles. The various rotations of the twisted ribbon model corresponded well with the different orientations of randomly dispersed PHF. The electron-dense regions of individual PHF turns previously thought to represent a cross-over site of paired filaments corresponded to the edge of the twisted ribbon when the ribbon was oriented perpendicular to the filament axis. These data indicate that the overall configuration of PHF is a twisted ribbon but does not exclude possible configuration restrictions due to an ordered arrangement of subunits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050318
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Alzheimer paired helical filaments: a comparison with the twisted ribbon model (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 194-197 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer's disease ; Paired helical filaments ; Electron microscopy ; Tau
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate if Alzheimer paired helical filaments (PHF) closely resemble twisted ribbons, as indicated by recent high-resolution ultrastructural studies, we compared physical models of twisted ribbons with electron microscopic images of PHF. Uranyl-acetate-stained, isolated PHF with one or two helical turns were compared with scale models of twisted ribbons with one and two helical turns rotated at different angles. The various rotations of the twisted ribbon model corresponded well with the different orientations of randomly dispersed PHF. The electron-dense regions of individual PHF turns previously thought to represent a cross-over site of paired filaments corresponded to the edge of the twisted ribbon when the ribbon was oriented perpendicular to the filament axis. These data indicate that the overall configuration of PHF is a twisted ribbon but does not exclude possible configuration restrictions due to an ordered arrangement of subunits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294320
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Membranous nephropathy and orbital malignant tumor (2000)
    Springer
    Pediatric nephrology 14 (2000), S. 53-55 
    Details
    ISSN: 1432-198X
    Keywords: Key words Membranous nephropathy ; Malignancy ; Nephrotic syndrome ; Paraneoplastic syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A 7-year-old girl with membranous nephropathy is reported who suffered 16 months later from an orbital rhabdomyosarcoma. Proteinuria disappeared at the time of the remission of the tumor. Membranous nephropathy as paraneoplastic syndrome is exceptional in children, since only two other cases associated with a solid tumor have been reported in the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050013
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    Paper (German National Licenses)
    Fulltext
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