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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 262 (1978), S. 113-123 
    ISSN: 1432-069X
    Keywords: Lymphoma ; Epitheliotropia ; Lymphom ; Epitheliotropie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Epitheliotropie cutaner Lymphome ist ein letztlich ungeklärtes Phänomen, das Epidermis wie epidermale Adnexe gleichermaßen betrifft. Dieses Phänomen wird in besonderer Weise bei Tumoren beobachtet, deren T-Zell-Genese wahrscheinlich ist. Allerdings ist es auch bei B-Zellymphomen (Immunocytomen) nachweisbar und insofern kein strenges Kriterium für die biologische Herkunft eines Lymphoms. Bei Keimzentrumstumoren fehlt in unserem Material die Epidermotropie. Jedoch muß eine aktive Einwanderung von Lymphomzellen in das Epithel von passiven, durch die Ausdehnung des Tumors bedingten druckverursachten Phänomenen unterschieden werden. Morphologisch können sich beide Reaktionen vollständig gleichen. Es wird eingehend dargelegt, daß Pautrier Mikroabscesse lediglich als Momentaufnahme des Epidermotropismus anzusehen sind und daß ihnen damit keine besondere Spezifität zukommt.
    Notes: Summary Epitheliotropia of malignant skin lymphomas is an unexplained phenomenon which equally affects epidermis and ectodermal appendages. This phenomenon is found especially in tumors of probable T-cell origin. However it can also be observed in B-cell lymphomas (immunocytomas) and is therefore not an exact criterium for the biological origin of a lymphoma. In the case of germinal center tumors we could not find evidence of epitheliotropia. An active invasion of neoplastic cellular infiltrate into the epithelium must be differentiated from the phenomenons caused by passive pressure, resulting from the expansion of the tumor. However, one has to remember that epitheliotropic malignant lymphomas invade the epidermis in all stages of development. It is shown, that Pautrier microabscesses are only a special non specific aspect of epidermotropia.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of epidemiology 9 (1993), S. 591-598 
    ISSN: 1573-7284
    Keywords: Malignant melanoma ; Skin cancer ; Epidemiology ; Educational work
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The growing incidence of all kinds of skin cancer is a worldwide phenomenon observed in the last decades. Malignant melanoma is of special concern because of its high death rate when in an advanced stage, poor therapeutic response and fast growing incidence. Malignant melanoma is primarily located on the skin and therefore well suited for early cancer detection. The “Deutsche Dermatologische Gesellschaft” carried out a highly successful information campaign in Germany. Under this roof we organised different campaigns. Following considerable success in a campaign in 1989, a total of 1467 patients were examined and advised in the course of a local initiative (Education Campaign “Black cancer”) in the city of Bochum (∼ 400,000 inhabitants) in the summer of 1991. In addition to full body examinations, important data were collected concerning the degree of knowledge about skin cancer, epidemiology, and the risk of skin cancer in general. As a result of the clinical examinations, 73 patients with strongly suspected skin cancer have been treated. Within this group, 14 malignant melanomas (1.0%) as well as 34 basal cell carcinomas (1.9%) were diagnosed. These numbers highly exceed the assumed risk incidence of skin cancer in Germany. Even on the assumption that the population was selective it is to be feared that a high number of individuals with skin cancer remain undetected and untreated. The majority of persons seeking advice had been motivated by the local media. The response and results of this local campaign indicate that further preventive measures for the general population in Europe are conceivable, meaningful and urgently needed.
    Type of Medium: Electronic Resource
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