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  • 1
    ISSN: 0942-0940
    Keywords: Epidural haematoma ; craniospinal tumour ; suboccipital craniectomy ; complication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report a case of bilateral supratentorial epidural haematomas occurring independently and consecutively after the removal of a craniospinal meningioma. The patient was a 45-year-old female who was treated surgically with complete cure.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2307
    Keywords: c-KIT ; Immunohistochemistry ; Malignant transformation ; Melanocyte ; SCF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to characterise the distribution and role of stem cell factor (SCF), a recently-reported growth factor for normal melanocytes, we carried out an immunohistochemical study on benign and malignant melanocytic tumours with a comparison with the presence of its receptor c-Kit proto-oncogene product (c-KIT). In normal skin, SCF was mainly observed in endothelial cells of blood vessels but not frequently in basal melanocytes, whereas c-KIT was predominantly localised in tissue mast cells. In benign neoplastic melanocytes (common melanocytic naevi), localisation of SCF and c-KIT was complementary: SCF was mostly found in dermal naevus cells while c-KIT was revealed in epidermal naevus cells, although the expression of the latter antigen was not frequent. Malignant melanoma cells showed less frequent expression of these antigens than those in benign lesions. Of five cultured melanoma cell lines, SCF was observed in only one, and c-KIT was not found in any melanoma cells. No quantitative or qualitative alterations assessed by Western blot analysis were induced in the presence of phenotypic modifiers (sodium butyrate and HMBA). Present data suggest that loss of SCF expression in neoplastic melanocytes is commonly associated with malignant transformation of pigment cells rather than loss of its receptor c-KIT.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1612-1112
    Keywords: High-performance TLC ; Metal complexes ; Tetrakis (4-methylphenyl) porphine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The metal complexes ofmeso-tetrakis (p-tolyl) porphine (TTP) are chromatographed on octadecyl-bonded silica gel thin-layer with various organic solvents of relatively high polarity used as the eluent. The mobility of the metal-TTP complex depends on its centralmetal, increasing in the order of Cu(II)〈Pd(II)≈NI(II)〈TTP free acid〈V(IV) as vanadyl〈Zn(II)〈Mg(II), although some irregularities are found with the different developing solvents used. The concept of Hildebrand's solubility parameter is applied to the discussion of the mobility of each compound, on the solvents used as the developer. Successful separation of the TTP compounds is performed by using a mixture of acetone and acetonitrile as the developer, although the Ni- and Pd-complexes are not completely resolved.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Metal complexes ; Tetrakis(4-methylphenyl)porphine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The feasibility of reversed-phase high-performance liquid chromatography for the separation of several metal complexes ofmeso-tetrakis(p-tolyl)porphine (TTP) is described. A combination of an octadecyl-bonded stationary phase with a non-aqueous polar mobile phase, such as an acetone-acetonitrile mixture, has proved effective for the separation. Thus, the TTP complexes of Mg, VO, Ni, Cu, Zn, and Pd and also TTP free acid were successfully separated in about 10min on a Li-Chrosorb RP-18 column (7μm, 250×4mm i.d.) with a 70∶30 (vol/vol) mixture of acetone and acetonitrile at a flow-rate of 1 mlmin−1.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1612-1112
    Keywords: High-Performance TLC ; Metal complexes ; Etioporphyrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The RF values were obtained for etioporphyrin I (H2Etio) and its vanadyl, nickel and copper complexes on cellulose, silica gel, and octyl-bonded silica HPTLC plates, with various organic solvents. The mobility of these compounds tends to increase in the following order: (1) on cellulose, VOEtio 〈 H2Etio 〈 CuEtio ≤ NiEtio; (2) on silica gel, H2Etio 〈 VOEtio 〈 NiEtio ≤ CuEtio; (3) on octyl-bonded silica, CuEtio 〈 NiEtio 〈 VOEtio and the apparent mobility of H2Etio relative to metal-Etio complexes depends on the developing solvent used. Complete separation of these four Etio compounds can be accomplished on an octyl-bonded silica plate with either methanol or acetone.
    Type of Medium: Electronic Resource
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