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  • 1
    ISSN: 1432-0584
    Keywords: Non-Hodgkin lymphoma ; High-grade malignancy ; Lymphoblastic lymphoma ; Immunoblastic lymphoma ; Centroblastic lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Comparison of clinical data of 64 patients with centroblastic lymphoma, 55 patients with immunoblastic lymphoma and 31 patients with lymphoblastic lymphoma not only confirmed the original assumption of high-grade malignancy as proposed by the concept of the Kiel classification but also demonstrated distinct clinical differences, particularly between lymphoblastic lymphoma and the two other entities. Rapid lymph node enlargement as well as steep fall of survival curves within the first year after diagnosis were common characteristics. Bimodal age distribution, predominance of males and early generalization of disease were typical features of lymphoblastic lymphoma; elderly patients and patients with the unclassified subtypes of lymphoblastic lymphoma exhibited the worst prognosis. Whereas patients with centroblastic and immunoblastic lymphomas showed similar distribution of age, sex and initial stage of disease, patients with immunoblastic lymphoma presented more frequently with a reduced performance status and showed a poorer response to radio- and chemotherapy resulting in a worse prognosis discernible after the first year of follow-up. Generalization during course of the disease was significantly more frequent in immunoblastic than in centroblastic lymphoma.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 52 (1974), S. 649-650 
    ISSN: 1432-1440
    Keywords: Megakaryocyte ; chronic myelocytic leukemia ; acute leukemia ; erythroleukemia ; Megakaryocyt ; chronisch myeloische Leukämie ; akute Leukämie ; Erythroleukämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In vereinzelten Fällen von chronisch myeloischer Leukämie, akuter Leukämie und Erythroleukämie wurden neben „Mikrokaryocyten“ noch kleinere Formen des megakaryocytären Systems unter 300µm2 im Knochenmark und teilweise im Blut gefunden. Mit Fortschreiten dieser Erkrankung nimmt die Anzahl dieser Zellen zu. Dem morphologischen Erscheinungsbild nach kann es sich um Degenerationsformen der „Mikrokaryocyten“ bzw. kleiner Megakaryocyten handeln.
    Notes: Summary Fifteen of 63 cases of chronic myelocytic leukemia, acute leukemia and erythroleukemia showed, in addition to microkaryocytes, another abnormal type of megakaryocytes which were smaller than 300µm2 and of different morphological appearance. These extremely small megakaryocytes appeared in 4 of 15 patients in the peripheral blood. The relative frequency of the cells increased with the progress of the disease. The morphologic appearance suggests that these cells are degenerative forms of microkaryocytes or of small megakaryocytes.
    Type of Medium: Electronic Resource
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