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  • Polytrauma  (2)
  • Fish skeleton  (1)
  • Hounsfield units  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Mutations affecting pigmentation and shape of the adult zebrafish (1996)
    Springer
    Development genes and evolution 206 (1996), S. 260-276 
    Details
    ISSN: 1432-041X
    Schlagwort(e): Key words Pigment pattern ; Fin ; Fish skeleton ; Tyrosinase ; Zebrafish
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract  Mutations causing a visible phenotype in the adult serve as valuable visible genetic markers in multicellular genetic model organisms such as Drosophila melanogaster, Caenorhabditis elegans and Arabidopsis thaliana. In a large scale screen for mutations affecting early development of the zebrafish, we identified a number of mutations that are homozygous viable or semiviable. Here we describe viable mutations which produce visible phenotypes in the adult fish. These predominantly affect the fins and pigmentation, but also the eyes and body length of the adult. A number of dominant mutations caused visible phenotypes in the adult fish. Mutations in three genes, long fin, another long fin and wanda affected fin formation in the adult. Four mutations were found to cause a dominant reduction of the overall body length in the adult. The adult pigment pattern was found to be changed by dominant mutations in wanda, asterix, obelix, leopard, salz and pfeffer. Among the recessive mutations producing visible phenotypes in the homozygous adult, a group of mutations that failed to produce melanin was assayed for tyrosinase activity. Mutations in sandy produced embryos that failed to express tyrosinase activity. These are potentially useful for using tyrosinase as a marker for the generation of transgenic lines of zebrafish.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004270050051
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  • 2
    Digitale Medien
    Digitale Medien
    Distribution and function of alveolar cells in multiply injured patients with trauma-induced ARDS (1988)
    Springer
    Intensive care medicine 14 (1988), S. 602-609 
    Details
    ISSN: 1432-1238
    Schlagwort(e): ARDS ; Alveolar cells ; Bronchoalveolar lavage ; Lung contusion ; Polytrauma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To determine whether alveolar cells are involved in the pathogenesis of adult respiratory distress syndrome (ARDS), we assessed the distribution and function of alveolar cells from 30 polytraumatized patients with trauma-induced respiratory failure, 5 of whom also had lung contusion. Cells were obtained by bronchoalveolar lavage performed daily begining on the day of trauma and continuing for 14 days. Neutrophils constituted about 60% of lavage cells in ARDS patients with lung contusion 0–2 days after polytrauma and about 50% in ARDS patients without lung contusion. In ARDS patients with lung contusion the neutrophil fraction decreased to 52% 3–6 days after trauma and to 40% 7–14 days after trauma. In patients without lung contusion the neutrophil fraction increased to 77% and then decreased to 60% at these times. Total cell counts in ARDS patients with lung contusion were more than twice as high as in patients without lung contusion 0–2 days after trauma. The difference in total cell counts decreased during days 3–6 and disappeared by day 7. In all patients morphologically altered alveolar cells were observed 4 days and more after trauma. In non-survivors significantly more altered cells were found. The chemiluminescence-response pattern of the alveolar cells was enhanced throughout the study and correlated with the neutrophil fraction (r=0.6). The neutrophil fraction also correlated with the pulmonary vascular resistance during the first two days after trauma (r=0.53). We conclude that alveolar cells are involved in the pathogenesis of trauma-induced ARDS and that the alveolar cell distribution is different in patients with and without lung contusion during the development of posttraumatic respiratory failure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00256763
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  • 3
    Digitale Medien
    Digitale Medien
    Postpartum CT examination of the heads of full term infants (1980)
    Springer
    Neuroradiology 20 (1980), S. 145-154 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Hemorrhage, intracranial ; Infants, full term ; Computed tomography ; Hounsfield units
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Intracranial hemorrhage and decreased density of the cerebral parenchyma were the major findings on CT of 150 full term newborns in the first week of life. Clinically silent hemorrhage was rare. All neonates with severe intracranial bleeding had neurological abnormalities. A correlation was not found between hemorrhage and the mode of delivery. The site of hemorrhage has an important bearing on brain development. Periventricular hypodensity is an ambiguous finding which should be interpreted in conjunction with the clinical findings.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00341779
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  • 4
    Digitale Medien
    Digitale Medien
    173. Das Multiorganversagen auf der unfallchirurgischen Intensivstation (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 833-833 
    Details
    ISSN: 1435-2451
    Schlagwort(e): Sepsis syndrome ; Immunology ; Polytrauma organ failure ; Bronchoalveolar lavage ; Polytrauma ; Immunologie ; BAL ; Organversagen
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Prospektive immunologische Untersuchungen in der bronchoalveolären Lavage, im Blut und im Urin bei Polytraumatisierten sollten Marker zur Erkennung der Frühphase der Sepsis aufdecken. Die Sepsis begann bei 7 Patienten initial mit einer alveolären Zellaktivierung (Veränderung der Zellzahl und -funktion) durch Mediatorsubstanzen (Elastase, Komplementspaltprodukte, Àrachidonsäuremetabolite). Die Organschäden von Lunge, Niere, Leber und Herz-Kreislauf entwikkelten sich im Sinne von sekundären Funktionsstörungen erst 4 Tage später. Durch die Frühdiagnostik solcher Veränderungen konnten frühe therapeutische Konsequenzen eingeleitet werden.
    Notizen: Summary Prospective immunological monitoring using bronchoalveolar lavage, as well as urine and blood tests in patients with multiple injuries, revealed early signs of sepsis development. Sepsis initially began in 7 patients with alveolar cell activation and capillary leakage. Lung, kidney, liver, and heart failure occurred 4 days later in the form of secondary functional disturbances. These early diagnostic signs made appropriate therapy possible.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01297957
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