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  • 1
    Electronic Resource
    Electronic Resource
    The action of a toxin from the sea Anemone Anemonia sulcata upon mammalian heart muscles (1976)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 295 (1976), S. 55-62 
    Details
    ISSN: 1432-1912
    Keywords: Sea anemone ; Polypeptide ; Mammalian hearts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cardiac activity of toxin II, a basic polypeptide (m.w.: 4770) from the sea anemone Anemonia sulcata, was investigated in isolated electrically driven guinea-pig and rat auricles, Langendorff heart preparations of guinea-pigs and cat heart-lung preparations. Low concentrations of toxin II (2–100 nM) evoked a dose-dependent positive inotropic effect in the three different heart muscle preparations investigated. Higher concentrations of toxin II produced toxic symptoms like contracture and arrhythmia in auricles and atria (about 25 nM). In isolated cat hearts high toxin II concentrations (about 160 nM) caused unusual toxic symptoms such as long periods of ventricular fibrillation alternating with periods of normal cardiac activity. In rat and guinea-pig auricles as well as in Langendorff hearts of guinea-pigs the extent and rate of the positive inotropic effect induced by toxin II depended on the extracellular calcium concentration (0.45 to 2.7 mM). Toxin II did not alter the heart rate in spontaneously beating isolated cat hearts. In electrically driven guinea-pig auricles, the rate of the inotropic effect induced by toxin II was accelerated by increasing stimulation frequencies. Toxin II did not change the coronary flow in Langendorff heart preparations of guinea-pigs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00509773
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The positive inotropic action of glucagon on the cat heart in situ (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 531-533 
    Details
    ISSN: 1432-1440
    Keywords: Glucagon ; cat heartin situ ; β-blockade ; dose response curve ; Glucagon ; Katzenherzin situ ; β-Blockade ; Dosis-Wirkungskurve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die positiv inotrope Wirkung von Glucagon wurde am Katzenherzen in situ ermittelt. (dP/dt) max nahm dosisabhängig zu und es wurde eine Dosis-Wirkungskurve (3–40 µg Glucagon/kg) angefertigt. Der Verlauf dieser Kurve wurde von einer gleichzeitigen Propranolol-Infusion nicht wesentlich beeinflußt.
    Notes: Summary The positive inotropic action of glucagon was assessed on the cat heartin situ. (dP/dt) max in the left ventricle increased in a dose dependent manner (3–40 µg/kg) and a dose response curve could be established. This curve was not significantly influenced by a simultaneous infusion of propranolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487301
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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