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  • 1
    Electronic Resource
    Electronic Resource
    Does the serum level of IgA-alpha-1-antitrypsin complex correlate with radiological progression in early rheumatoid arthritis? A 3-year follow-up study (1995)
    Springer
    Rheumatology international 14 (1995), S. 227-230 
    Details
    ISSN: 1437-160X
    Keywords: Early rheumatoid arthritis ; IgA-alpha-1-antitrypsin complex ; Radiological deterioration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We followed the levels of serum IgA-alpha-1-antitrypsin (IgA-AT) complex in 37 patients with early rheumatoid arthritis (RA) during the first 3 years of the disease. The changes in IgA-AT were correlated with a radiological damage score (DS) of the hands assessed according to Larsen. At the onset of the disease, the IgA-AT serum concentration was significantly higher as compared to the control group (0.72±0.22 U vs 0.29±0.14 U, P〈0.01). The level significantly decreased during the 3-year observation period. The DS was significantly higher after 3 years. However, this difference was due to changes in only 11 patients; in 26 patients the DS was almost unchanged. In the group of 11 patients with radiological progression, the level of IgA-AT either remained high or increased significantly (0.95±0.18 U at the onset, 0.97±0.25 U after 3 years), whereas we observed a decrease in IgA-AT in 26 patients without radiological progression (0.63±0.16 U at the onset of the disease, 0.45±0.10 U after 3 years, P〈0.01). Moreover, a relationship between changes in IgA-AT serum level and radiological progression was shown (r=0.60, P〈0.01). Our studies suggested that the relationship between IgA-AT level and radiological progression of the disease should be considered. We cannot exclude the possibility that the constant high level of IgA-AT may cause worsening in bone erosions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262087
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  • 2
    Electronic Resource
    Electronic Resource
    Interleukin-10 and interleukin-6 in lupus erythematosus and rheumatoid arthritis, correlations with acute phase proteins (1997)
    Springer
    Clinical rheumatology 16 (1997), S. 275-278 
    Details
    ISSN: 1434-9949
    Keywords: Systemic Lupus Erythematosus ; Rheumatoid Arthritis ; Interleukin-10 ; Interleukin-6 ; Acute Phase Proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We sought to investigate the influence of interleukin-10 (IL10) and IL-6 on the acute phase proteins (APP) in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). IL-10, IL-6, Creative protein (CRP), alpha-1-acid glycoprotein (AGP), and alpha1 antichymotrypsin (ACT) serum levels were determined in one hundred-eight patients (71 with SLE, 37 with RA). Quantification of the serum IL-10 level showed increased levels in SLE and RA patients as compared to healthy controls. Serum IL-6 level was found to be elevated in SLE and RA patients. A correlation between IL-10 and IL-6 serum level was found only in SLE. CRP and AGP serum levels were increased in RA as compared to controls, whereas in SLE only AGP was found elevated. A statistically significant correlation between IL-6 serum level and CRP, AGP and ACT was found only in RA. No correlation between IL-10 and serum level of CRP, AGP and ACT was established. Since IL-10 has a potent immunosuppressive activity, we expected it to be negatively correlated with APP levels. Surprisingly, IL-10 did not correlate with APP either in SLE or RA patients. However, the elevation of IL-10 serum levels in SLE and RA and the correlation between IL-10 and IL-6 in SLE may suggest that IL-10 may play a central role in inflammatory connective tissue diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02238963
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  • 3
    Electronic Resource
    Electronic Resource
    Still's disease in children and adults: A distinct pattern of acute-phase proteins (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 258-260 
    Details
    ISSN: 1434-9949
    Keywords: Affinity immunoelectrophoresis ; Glycosylation of α1-acid glycoprotein, ferritin ; Still's disease in adults ; Still's disease in children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Crossed affinoimmunoelectrophoresis with Con A as a ligand was used to examine the microheterogeneity of α1-acid glycoprotein (AGP) and α1-antichymotrypsin (ACT) in sera of patients with child-onset and adult-onset Still's disease. The reactivity of both proteins was increased in sera of adults and decreased in sera of children with active disease, when compared with normal values. We also found statistically significant differences in serum concentration of ACT and ferritin in both diseases. This result suggests different pathogenic mechanisms of Still's disease in children and adults. Serum concentration of ferritin and ACT could be of value as a combined marker for the adult, but not the juvenile form of Still's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01451062
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    Paper (German National Licenses)
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