ISSN:
1432-2277
Schlagwort(e):
Key words Banff classification
;
Graft survival
;
Prognostic value
;
Rejection
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract We evaluated whether classification of renal allograft biopsies according to the Banff schema is a predictive parameter for graft survival. All patients who received renal transplants between 1980 and 1994 at the University of Erlangen-Nuremberg (n = 1141) were included. Patients who had undergone a renal biopsy (n = 306) were divided into groups according to the Banff classification. We observed a correlation (P 〈 0.05) between biopsy findings and the following patient characteristics: donor/recipient age, donor/recipient gender, panel reactive antibodies, maintenance immunosuppression, and primary renal disease. Compared to patients who did not undergo renal biopsy (55.9 %), 5-year graft survival was reduced in patients with moderate acute rejection defined by tubulitis (20.6 %, P = 0.03) or arteritis (0 %; P 〈 0.0001) and in patients with severe acute rejection (24.4 %, P 〈 0.0001). Conclusions: (1). The Banff classification is a predictive parameter for renal allograft survival. (2). Certain characteristics predispose patients to certain biopsy findings.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/s001470050291
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