ISSN:
1432-1076
Schlagwort(e):
Key words Kawasaki disease
;
Haemophagocytic syndrome
;
Inflammatory cytokine
;
Interferon-gamma
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract A 32-month-old Japanese boy exhibited haemophagocytic syndrome (HPS) during the recurrent course of Kawasaki disease. Despite repeated γ-globulin therapy, he developed cytopenia with marked hepatomegaly and evidence of histiocytic haemophagocytosis in the bone marrow. Serum levels of interferon-γ and tumour necrosis factor, but not of interleukin-1β, increased in parallel with his symptoms. No confirmation was obtained of the association of toxic reactions to the used drugs. No coronary lesions remained as sequelae. Conclusion Cytopenia in Kawasaki disease could herald HPS, and the hypercytokinaemia involved in the two febrile syndromes might be of distinct nature.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02074830
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