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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 302 (1978), S. 341-343 
    ISSN: 1432-1912
    Keywords: Cyclic AMP ; Hypothalamus ; Genetically hypertensive rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In genetically hypertensive rats an altered catecholamine content of hypothalamic structures has been reported. In the present study cAMP was estimated in the hypothalamus and cortex of genetically hypertensive rats and compared with normotensive controls of the same strain. It is shown, that the cAMP content of the hypothalamus of the hypertensive animals was decreased to about 60% of control values, whereas there was no difference of the cAMP content in the cortical regions of the same animals. These results indicate an alteration of the adenyl cyclase-cAMP-phosphodiesterase system in hypothalamic structures of genetically hypertensive rats.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 56 (1984), S. 323-326 
    ISSN: 1432-1106
    Keywords: Calmodulin ; Radioimmunoassay ; Brain areas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A radioimmunoassay was used to measure the calmodulin content in eleven brain areas of the rat. Calmodulin showed an uneven distribution. Various cortical regions, striatum, hippocampus, amygdala and substantia grisea were highest in calmodulin content (15 μg/mg protein). Locus coeruleus, nucleus tractus solitarii (+A2 region) and A1 region, contained 7 μg calmodulin per mg protein and the cerebellum 4 μg/mg.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1459
    Keywords: Myelin basic protein ; Cerebrospinal fluid ; Multiple sclerosis ; Radioimmunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit Hilfe eines Radioimmunoassays wurde der Liquor von 105 Patienten auf Substanzen untersucht, die mit dem Fragment 89–169 des bovinen basischen Myelinproteins (BP) kreuzreagieren. Von 72 Patienten mit Multipler Sklerose hatten 52 einen höheren BP-Gehalt im Liquor als die Kontrollgruppe, d.h. mehr als 2 ng/ml. Dies war bei fast all jenen Patienten der Fall, bei denen der Liquor innerhalb von 2 Wochen nach einem akuten Schub bzw. zum Zeitpunkt einer deutlichen Verschlechterung des Zustandes bei der chronisch-progredienten Form gewonnen wurde. Der BP-Gehalt des Liquors nimmt zwischen dem 15. und 30. Tag nach Schubbeginn deutlich ab. In der schleichenden progredienten Form wurde mit einer Ausnahme kein erhöhter BP-Gehalt gefunden. Das basische Myelinprotein ist aber auch im Liquor von Patienten mit anderen neurologischen Erkrankungen zu finden. Hervorzuheben ist das Auftreten von BP im Liquor von Patienten mit Retrobulbär-neuritis. Der Nachweis von mit Bruchstück 89–169 kreuzreagierenden Substanzen im Liquor ist infolgedessen zwar nicht spezifisch für die Multiple Sklerose, ist aber ein wertvoller Parameter in der Diagnose und Einschätzung der MS.
    Notes: Summary Cerebrospinal fluid (CSF) from 105 patients was analyzed by radio-immunoassay for the presence of material cross-reactive with peptide 89–169 of bovine myelin basic protein (BP). In a group of 72 multiple sclerosis patients, 52 showed higher BP content than the control group, i.e. more than 2 ng/ml CSF. Increased BP or BP fragments could be detected in CSF from almost all patients who recently (within 2 weeks) had had an acute episode, or after deterioration in the progressive form of the disease. Fifteen to 30 days after the onset of exacerbation or in a stable period, BP content decreases and in the slowly progressive form was in the range of the control group with one exception. BP content was also elevated in the CSF of patients with other neurological diseases. The presence of BP in the CSF from patients with isolated retrobulbar neuritis is of particular interest. Thus the presence of material cross-reactive with BP fragment 89–169 is not specific for multiple sclerosis, but is a useful parameter in diagnosis and evaluation of MS.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 801-801 
    ISSN: 1435-2451
    Keywords: Shouldice repair ; Groin hernia ; Postoperative complications ; Recurrence rate ; Shouldice Hernioplastik ; Leistenbruch ; Postoperative Komplikationen ; Rezidivrate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In randomisierter Folge wurden monofile Polyglyconate bzw. Polyesterfäden zur Hernienreparation nach Shouldice verwandt. Bei 416 Operationen an 376 Patienten war die postoperative Komplikationsrate in beiden Gruppen gleichmäßig niedrig. Führend waren Hämatome bzw. Serome mit 3,4%, mit Redondrainage 2,4%, ohne diese 4,7%. Bei einem mittleren postoperativen Intervall von 401 Tagen fand sich ein echtes und ein Pseudorezidiv (Schenkelhernie) — entsprechend einer Rezidivquote von 0.2 bzw. 0,5 %. Hodenatrophien fanden sich in insgesamt 1 %. Damit hat sich die Hernioplastik nach Shouldice als sicheres Routineverfahren erwiesen.
    Notes: Summary In random order, monofile polyglyconate, or polyester sutures were used in Shouldice hernioplasty. In 416 operations on 376 patients, postoperative complications occurred at a similar low frequency in both groups. The incidence of hematoma and seroma was 3.4%. With subcutaneus drainage it was 2.4% and without it 4.7%. During a mean follow-up period of 401 days, only one real and one pseudorecurrence (femoral hernia) were observed, implying a recurrence rate of 0.2%–0.5%. The incidence of testicular atrophy was 1 %. It is concluded that Shouldice repair is a safe method of routine surgery for groin hernias.
    Type of Medium: Electronic Resource
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