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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 160 (1973), S. 196-205 
    ISSN: 1433-8580
    Keywords: Blast cell transformation ; Cytostatic drugs ; Immunosuppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Different groups of NMRI-mice were given single doses of 2, 10, 50, 250 or 1000 mg/kg of Cph or 6-MP. Other groups were applicated 7×10 mg/kg every alternate day. 2 days after the last dose lymph node and spleen cells were collected and stimulated with PHA. Stimulation was estimated by the quotient of the uptake of3H-thymidine in stimulated and unstimulated cultures. Controls were untreated animals. It could be demonstrated that only maximal doses could inhibit the stimulation. Cph was more efficient than 6-MP. Lymph node cells were more sensitive than spleen cells. Repeated application showed no effect. The results demonstrate that cytostatic drugs can inhibit blast cell transformationin vivo. The different results are due to the different mode of action of those substances and from the different populations of harvested cells.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 131 (1979), S. 43-48 
    ISSN: 1432-1076
    Keywords: Immunopathogenesis ; Infectious diseases ; Immune complexes ; Gammaglobulin injection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immune complexes (ICs) participate in the pathogenesis of various diseases and can be shown in 18% of all hospitalized patients (excluding those with infectious diseases) by means of a sensitive method such as the Raji-cell radioimmune assay. However, before this test can be applied to quantify disease activity in renal, connective tissue and neoplastic diseases, it must be recognized that febrile infections of the upper respiratory tract also induce ICs in 86% of all patients. The immune complexes containing microbial antigens can be reduced or removed by a single injection of human immunoglobulin. This is a simple method to distinguish between the immune complexes of different specifities. The resulting removal of some immune complexes may be the explanation for the claimed therapeutic effect of gammaglobulin injection in normogammaglobulinemic patients.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 53 (1975), S. 927-928 
    ISSN: 1432-1440
    Keywords: HB-Antigen ; Hepatitis ; Polyarthritis ; HB-Antigen ; hepatitis ; polyarthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 27 patients suffering from acute hepatitis serum and synovial-fluid were tested for HB-Ag. It was detected in the serum in 19 cases, in the synovial fluid in 2 cases, but never in both serum and synovial-fluid. HB-Ag was not found in 6 patients. Polyarthritis was seen in 10 cases; 5 of them carried HB-Ag in the serum, 2 in the synovial-fluid. A hepatitis B however, was also suspected in the 3 cases with polyarthritis lacking HB-Ag. The results suggest that virus B may persist in joints too and that polyarthritis associated with acute hepatitis is coupled to an infection with virus B.
    Notes: Zusammenfassung Bei 27 Patienten mit akuter Hepatitis wurden Synovialis und Serum auf das HB-Ag untersucht. Es fand sich 19mal im Serum, 2mal in der Synovialis, aber niemals in beiden. Bei 6 Patienten wurde es nicht gefunden. Eine Polyarthritis bestand in 10 Fällen, von denen 5 das HB-Ag im Serum und 2 in der Synovialis hatten. Doch auch bei den übrigen 3 Fällen mit Polyarthritis ohne HB-Ag war eine Hepatitis B anzunehmen. Die Ergebnisse zeigen, daß das Hepatitis-B-Virus auch in Gelenken persistieren kann und eine Polyarthritis bei akuter Hepatitis an eine Infektion mit Virus-B gebunden ist.
    Type of Medium: Electronic Resource
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