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  • HBV infection  (1)
  • Itraconazole  (1)
  • Simple-complex movements  (1)
  • 1
    ISSN: 1439-0973
    Keywords: Key words Paracoccidioidomycosis ; Therapy of paracoccidioidomycosis ; Mycosis ; Osteolysis ; Itraconazole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe long-term therapy for paracoccidioidomycosis occurring in a 61-year-old housepainter from Venezuela. The diagnostic examinations made in South America had shown pulmonary granulomatous lesions and an osteolytic pattern of the left knee that had been considered suspect of malignant disease with an indication for limb amputation. With the aid of fine needle aspiration biopsy (FNAB) and culture examination we diagnosed an osteomyelitis by Paracoccidioides brasiliensis and initiated therapy with itraconazole, 400 mg per day reduced to 200 mg per day after 2 months. At the end of 2 years of drug therapy, we observed complete regression of the pulmonary lesions and of the osteolytic area of the left knee. Moreover, we have periodically observed our patient to verify his clinical development and he is still in good health. We suggest that this pathology be considered in differential diagnosis of leprosy, tuberculosis, leishmaniasis, and systemic mycoses, even in non-endemic areas.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7284
    Keywords: HBV infection ; Health care personnel ; Occupational hazard
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A prevalence study of HBV serologic markers was carried out among hospital employees of ten departments of the Second School of Medicine in Naples, an urban area with a high prevalence of HBV infection. Departments and occupational categories were selected to represent a spectrum of different exposure to B virus infection. Workers in a large electronic plant in the same geographical area were screened as controls. HBsAg prevalence was 4.8% in the hospital community and 4.0% in control group. It rises to 4.3% in the Campania Region, where all screened workers live, and in some specific areas of the same region it rises to 12%. But no significant difference among seropositivities for at least 1 marker of HBV, considered to be a better indicator of occupational hazard, was found among personnel of different departments or belonging to different occupational categories. None of the occupational and non-occupational risk factors studied was found to be significantly associated with HBV infection. Two years later, an incidence study was carried out among susceptible subjects. Seropositivity for 1 marker was 2.2% among hospital workers and 2.8% in the control group. These figures are lower than the annual attack rate (5%) required for an acceptable cost-benefit ratio of vaccination against hepatitis B. Our results indicate that in a geographical area with HBV endemicity the occupational hazard for B virus infection is low in hospital workers because of the high number of immunized subjects and the contacts with infected people out of the hospital.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1590-3478
    Keywords: Functional MR ; Motor-premotor cortex ; Simple-complex movements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Scopo di questo studio è stato quello di dimostrare la possibile differenza di attivazione bilaterale per i movimenti delta mano non-dominants nei confronti di quella dominante come pure il diverso coinvolgimento delle aree corticali motorie durante l'esecuzione di movimenti complessi della mano rispetto ai movimenti semplici. È stato utilizzato un apparecchio standard di risonanza magnetica di 1,5 T, per tocalizzare le aree corticali motorie delta mano, utilizzando la tecnica BOLDc ed immagini FLASH a singola sezione. 10 soggetti destrimani sani sono stati utilizzati come volontari per to studio; gli stimoli motori consistevano nell'esecuzione di movimenti semplici (flesso-estensione delle dita) da parte sia delta mano dominante the di quella non dominante, e di movimenti complessi (opposizione delle 4 dita al pollice in maniera ripetuta secondo una sequenza stabilita, 2,4,3,5) da parte delta mano non-dominants. L'esecuzione dei movimenti semplici ha determinato l'attivazione controlaterale dell'area motoria primaria (MA); attivazione ipsilaterale è stata osservata solo per la mano non dominante. Anche l'area supplementare motoria (SMA) è stata attivata, con chiara prevalenza per quella controlaterale. L'entità di attivazione bilaterale delta MA non cambiava con l'esecuzione di movimenti complessi, mentre la SMA, così come l'area premotoria laterale (LPA), erano maggiormente attivate in entrambi i lati con questo tipo di stimolo. In conclusione, la MA ipsilaterale è attivata per movimenti — anche se semplici — eseguiti con la mano non-dominants; esiste una notevole attività funzionale, comprendente la SMA sia controlaterale che ipsilaterale, durante l'esecuzione di movimenti complessi.
    Notes: Abstract The purpose of this study was to show a gradient of possible bilateral activation for movements of the non-dominant vs. dominant hand, as well as for areas involved in complex vs. simple hand movements. A standard 1.5 T magnetic resonance imaging (MRI) system has been utilized to localize the cortical motor hand areas, using the blood oxygen level dependent contrast (BOLDc) technique and single-section fast low-angle shot (FLASH) imaging. Ten normal right-handed subjects volunteered for the study. The motor tasks consisted of simple (flexion-extension) finger movements of either hand, and complex movements (finger-to-thumb opposition in a repeating, pre-planned sequence) of the non-dominant hand. Simple movements caused contralateral activation of the primary motor area (MA); ipsilateral activation was observed for the non-dominant hand only. Supplementary motor area (SMA) was also activated, with a clear contralateral prevalence. The ratio of bilateral activation of MA did not change with complex movements of the non-dominant hand, while SMA as well as lateral premotor area were largely bilaterally activated in this task. In conclusion, the ipsilateral MA is activated for movements — even simple — performed with the non-dominant hand. There is widespread functional activity, involving both contralateral and ipsilateral SMA, for complex movements.
    Type of Medium: Electronic Resource
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