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  • 1
    ISSN: 1432-1440
    Keywords: Heart transplantation ; Heart ubiquinone ; Blood and plasma ubiquinone ; Plasma α-tocopherol ; Transplant rejection ; Free radicals ; Antioxidants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nine patients who underwent heart transplantation (one female; average age 48 ± 11, range 19–58 years) were followed in respect to contents of right-sided heart septum, blood and plasma ubiquinone (UQ), plasma α-tocopherol (αT), and plasma free cholesterol (FC). In contrast to healthy persons, substantial inter- and intraindividual variations were observed; individually low values were seen with rejection. Heart muscle UQ in well-treated patients averaged 0.33 ± 0.08, range 0.06–0.58 μg mg−1 (0.38 ± 0.09 μmol g−1 dry weight) and was not different from healthy individuals. Plasma UQ, αT; and FC averaged 0.63 ± 0.33 μg ml−1 (P 〈 0.05 versus sedentary controls), 8.1 ± 4.0 μg ml−1 (P 〈 0.01), and 0.52 ± 0.23 mg ml−1 (P 〈 0.05). Corresponding molar values were 0.73 ± 0.37 (UQ), 2.0 ± 1.1 μmol l−1 (αT), and 1.42 ± 0.54 mmol 1−1 (FC). Blood and plasma UQ values were identical. A saturationlike relationship was found between heart and blood UQ: blood contents below 0.7 μg ml−1 (0.8 μmol l−1) corresponded to markedly lowered heart contents. In four patients in whom blood samples were taken close to a fatal complication it averaged 0.42 μg ml−1 (0.49 μmol l−t, P 〈 0.01). When low heart muscle and blood ubiquinone were present, other variables such as left ventricle cardiac output or cycle ergometer performance was markedly impaired. Plasma UQ and off covaried with a marker of the lipoidal deposit volume, plasma FC. The ratios UQ and αT over FC (N-UQ and N-αT) are alternative means for clinical evaluation. Mean N-αT was relatively more depleted than N-UQ. On an individual basis this was more pronounced for those with low N-UQ than for those with high values.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 173 (1997), S. 33-41 
    ISSN: 1573-4919
    Keywords: blood andplasma vitamin Q ; ubiquinone ; coenzyme Q10 ; CoQ10 ; plasma vitamin E ; a-tocopherol ; antioxidants ; oxygen burst ; free radicals ; membrane trauma ; erythrocyte ; hemolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Whole blood vitamin Q (ubiquinone), plasma vitamins Q and E(alpha-(a-)tocopherol) and free cholesterol (FC) were studied before(control or base-line value, sample I) and during open chest surgery andextracorporal circulation (samples II-IV) in 10 male IHD patients. Identityexisted between control whole blood and plasma ubiquinone. During surgery anincreased discrepancy with lower plasma vitamin Q levels were seen. Controlplasma vitamins Q, E and FC averaged 0.88 ± 0.16 (SE), 12.1 ±2.2 mg × 1-1 and 0.75 ± 0.15 g × 1-1. Corresponding molarvalues were 1.02 ± 0.17, 28.1 ± 5.1 µmol × 1-1 and1.94 ± 0.74 mmol × 1-1. Vitamin Q and E decreased continuouslyand averaged 0.64 mg × 1-1 in sample IV (0.74 µmol × 1-1,p 〈 0.001) and 9.4 mg × 1-1 in sample III (21.8 µmol ×1-1, p 〈 0.001). Hemolysis in all sample IV vials, ruined all vitamin Edeterminations. When normalized for FC (NQ and NE), decreases were found tobe 17 (IV) and 12% (III), respectively. Large interindividual variationsexisted. High control NQ and NE values allowed a larger antioxidant vitamindepletion. High NQ seemed also to be a prerequisite for NE depletion. Inaddition, signs indicated an active liver vitamin Q release for patientsrich in control antioxidant values. It was suggested that the antioxidantvitamin depletion did not prevent from radical trauma to membrane structurallipids (especially omega-3 fatty acids or vitamin F1), less membranefluidity, erythrocyte fragility and hemolysis.
    Type of Medium: Electronic Resource
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