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  • 1
    Digitale Medien
    Digitale Medien
    Lipid peroxidation in lung tissue after chest trauma and correlation with the duration of the post-trauma survival period (1998)
    Springer
    International journal of legal medicine 111 (1998), S. 256-260 
    Details
    ISSN: 1437-1596
    Schlagwort(e): Key words Chest trauma ; Lipid peroxidation ; Reperfusion ; Lung ; Postmortem
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Notizen: Abstract Blunt chest trauma is a frequently encountered cause of death in forensic pathology and one of the organs most likely to be affected are the lungs. Assuming that the victim survives the initial trauma, reperfusion processes take place, free radicals are formed and lipid peroxidation occurs. The aim of this study was to ascertain whether the length of the survival time is correlated with the extent of lipid peroxidation in the lung tissue following such ischaemia-reperfusion processes. A study of 470 samples taken from all five pulmonary lobes from 94 cadavers was carried out. Cases were allocated to different groups according to whether there was chest trauma and/or a known survival period. Lipid peroxidation was investigated by determining malondialdehyde (MDA) levels. The lowest mean level of peroxidation was found in control cases showing no evidence of chest trauma at autopsy and no apparent survival period. Our results suggest that the level of lipid peroxidation in lung tissue can be a reliable indicator of survival processes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004140050164
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  • 2
    Digitale Medien
    Digitale Medien
    Study of postmortem blood circulation (1989)
    Springer
    International journal of legal medicine 103 (1989), S. 27-32 
    Details
    ISSN: 1437-1596
    Schlagwort(e): Postmortem heart contraction ; Postmortem blood circulation ; Postmortale Blutverteilung ; Herzkontraktionen, postmortem
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Der Zweck unserer Arbeit war das Studium der Erscheinungen der Blutvolumenverteilung und des Einflusses der Verteilung der Substanzen, die verschiedene Molekulargewichte (194.2 und 150,000 Da) haben, nach dem Tode. Man hat 20 Kaninchen benutzt, die in drei Gruppen eingeteilt wurden. In den linken Ventrikel wurde der einen Gruppe Lipiodol ultrafluide, der anderen Omnitrast und und der letzten eine Mischung Radioisotop aus Aminohippursaure und menschlichem Gammaglobulin gespritzt. Unsere Ergebnisse beweisen die Wichtigkeit der Erscheinungen in Verbindung mit der Kontraktion postmortem des linken Ventrikels, der arteriellen Gefäßlage, der Diffusionsvorgänge in Verbindung mit den physikalischchemischen Merkmalen der Substanzen und der anatomischen Gefäßaufteilung. Bei den Versuchskaninchen kommt es sogar im Urin zum Vorhandensein einer Diffusion Aminohippursaure post mortem.
    Notizen: Summary The objective of this work was to study the postmortem redistribution of blood volumes and its influence of the distribution of substances of different molecular weight (194.2 and 150,000 Da). Lipiodol Ultrafluide, Omnitrast, or a radioisotopic mixture of aminohippuric acid and human IgG were injected into the left ventricle of a total of 20 rabbits divided into three groups. Our results demonstrate the importance of related factors, including left ventricular postmortem contraction, the arterial vascular bed, diffusion processes connected to the physicochemical characteristics of the substances, and the anatomical distribution of the vessels. Postmortem diffusion of aminohippuric acid to the urine was observed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00203940
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Usefulness of myosin in the postmortem diagnosis of myocardial damage (1995)
    Springer
    International journal of legal medicine 108 (1995), S. 14-18 
    Details
    ISSN: 1437-1596
    Schlagwort(e): Myocardial ischaemia ; Biochemistry Myosin ; Postmortem ; Pericardial fluid
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Notizen: Abstract In some situations the postmortem diagnosis of myocardial infarction is made difficult by the brief course of the fatal episode or by interferences caused by autolysis. In such cases, biochemical indices may provide a useful adjunct to morphological studies. Myosin is the main component of the contractile apparatus of muscle cells, so its determination may well be useful to evaluate myocardial injury. The purpose of the present study was to establish the diagnostic efficacy of postmortem myosin heavy chain determinations using monoclonal antibodies and to compare this data with structural findings used to diagnose acute myocardial ischaemia. We studied 105 cadavers with a mean age of 61.63 ± 2.21 years. Cases were allocated to 1 of 7 diagnostic groups depending on the probable intensity of myocardial damage and cause of death. The highest serum and pericardial fluid values of myosin heavy chains were seen in subjects who showed morphological evidence of myocardial ischaemia. Mean pericardial fluid/serum ratios differed significantly between subjects with and without observable signs of heart damage.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01845610
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Cardiac troponin I (cTn I) and the postmortem diagnosis of myocardial infarction (1998)
    Springer
    International journal of legal medicine 111 (1998), S. 173-176 
    Details
    ISSN: 1437-1596
    Schlagwort(e): Key words Myocardial ischaemia ; Biochemistry ; Troponin ; Postmortem ; Pericardial fluid
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Notizen: Abstract In clinical practice several biochemical markers are used for the diagnosis of myocardial infarction. Because of its extremely high specificity for myocardial damage, cardiac troponin I (cTn I) is frequently used. The aim of this study was to evaluate the diagnostic efficacy of postmortem cTn I determinations in pericardial fluid and serum and to compare these results with other biochemical markers and with structural findings used to diagnose acute myocardial ischaemia. We studied 89 cadavers with a mean age of 51.38 ± 2.04 (SD 19.27 years). Cases were allocated to 1 of 4 diagnostic groups depending on the probable intensity of myocardial damage and cause of death. In pericardial fluid we obtained statistically significant differences for the four biochemical parameters, while in serum myosin heavy chains and myoglobin showed statistically significant differences. The highest levels of biochemical markers in pericardial fluid were observed in subjects who had died from definite myocardial infarction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004140050143
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Study of postmortem blood circulation (1989)
    Springer
    International journal of legal medicine 103 (1989), S. 27-32 
    Details
    ISSN: 1437-1596
    Schlagwort(e): Postmortem heart contraction ; Postmortem blood circulation ; Postmortale Blutverteilung ; Herzkontraktionen, postmortem
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Der Zweck unserer Arbeit war das Studium der Erscheinungen der Blutvolumenverteilung und des Einflusses der Verteilung der Substanzen, die verschiedene Molekulargewichte (194.2 und 150,000 Da) haben, nach dem Tode. Man hat 20 Kaninchen benutzt, die in drei Gruppen eingeteilt wurden. In den linken Ventrikel wurde der einen Gruppe Lipiodol ultrafluide, der anderen Omnitrast und und der letzten eine Mischung Radioisotop aus Aminohippursäure und menschlichem Gammaglobulin gespritzt. Unsere Ergebnisse beweisen die Wichtigkeit der Erscheinungen in Verbindung mit der Kontraktion postmortem des linken Ventrikels, der arteriellen Gefäßlage, der Diffusionsvorgänge in Verbindung mit den physikalischchemischen Merkmalen der Substanzen und der anatomischen Gefäßaufteilung. Bei den Versuchskaninchen kommt es sogar im Urin zum Vorhandensein einer Diffusion Aminohippursäure post mortem.
    Notizen: Summary The objective of this work was to study the postmortem redistribution of blood volumes and its influence of the distribution of substances of different molecular weight (194.2 and 150,000 Da). Lipiodol Ultrafluide, Omnitrast, or a radioisotopic mixture of aminohippuric acid and human IgG were injected into the left ventricle of a total of 20 rabbits divided into three groups. Our results demonstrate the importance of related factors, including left ventricular postmortem contraction, the arterial vascular bed, diffusion processes connected to the physicochemical characteristics of the substances, and the anatomical distribution of the vessels. Postmortem diffusion of aminohippuric acid to the urine was observed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01255843
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Vitreous humor fructosamine concentrations in the autopsy diagnosis of diabetes mellitus (1999)
    Springer
    International journal of legal medicine 112 (1999), S. 275-279 
    Details
    ISSN: 1437-1596
    Schlagwort(e): Key words Diabetes mellitus ; Biochemistry ; Fructosamine ; Postmortem ; Vitreous humor
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Notizen: Abstract In clinical practice, biochemical markers, particularly serum glucose levels are used to diagnose diabetes mellitus. However, at autopsy this marker is of no value due to the substantial and capricious fluctuations in glucose levels after death. The aim of this study was to evaluate the usefulness of the postmortem determination of fructosamine in vitreous humor for confirming the presence of antemortem hyperglycemia. This was a study of 92 cadavers with a mean age of 60.05 years (SD 17.73) and a mean postmortem interval of 17.02 h (SD 9.76, range 2–58 h). Cases were assigned to two diagnostic groups according to the antemortem diagnosis of diabetes mellitus based on the patients’ medical records. In vitreous humor statistically significant differences were found in glucose and fructosamine concentrations between the two diagnostic groups, the highest values being obtained in the group of subjects with a previous diagnosis of diabetes mellitus.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004140050249
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