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  • 1
    Electronic Resource
    Electronic Resource
    Lipid peroxidation in lung tissue after chest trauma and correlation with the duration of the post-trauma survival period (1998)
    Springer
    International journal of legal medicine 111 (1998), S. 256-260 
    Details
    ISSN: 1437-1596
    Keywords: Key words Chest trauma ; Lipid peroxidation ; Reperfusion ; Lung ; Postmortem
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract Blunt chest trauma is a frequently encountered cause of death in forensic pathology and one of the organs most likely to be affected are the lungs. Assuming that the victim survives the initial trauma, reperfusion processes take place, free radicals are formed and lipid peroxidation occurs. The aim of this study was to ascertain whether the length of the survival time is correlated with the extent of lipid peroxidation in the lung tissue following such ischaemia-reperfusion processes. A study of 470 samples taken from all five pulmonary lobes from 94 cadavers was carried out. Cases were allocated to different groups according to whether there was chest trauma and/or a known survival period. Lipid peroxidation was investigated by determining malondialdehyde (MDA) levels. The lowest mean level of peroxidation was found in control cases showing no evidence of chest trauma at autopsy and no apparent survival period. Our results suggest that the level of lipid peroxidation in lung tissue can be a reliable indicator of survival processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140050164
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Vitreous humor fructosamine concentrations in the autopsy diagnosis of diabetes mellitus (1999)
    Springer
    International journal of legal medicine 112 (1999), S. 275-279 
    Details
    ISSN: 1437-1596
    Keywords: Key words Diabetes mellitus ; Biochemistry ; Fructosamine ; Postmortem ; Vitreous humor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract In clinical practice, biochemical markers, particularly serum glucose levels are used to diagnose diabetes mellitus. However, at autopsy this marker is of no value due to the substantial and capricious fluctuations in glucose levels after death. The aim of this study was to evaluate the usefulness of the postmortem determination of fructosamine in vitreous humor for confirming the presence of antemortem hyperglycemia. This was a study of 92 cadavers with a mean age of 60.05 years (SD 17.73) and a mean postmortem interval of 17.02 h (SD 9.76, range 2–58 h). Cases were assigned to two diagnostic groups according to the antemortem diagnosis of diabetes mellitus based on the patients’ medical records. In vitreous humor statistically significant differences were found in glucose and fructosamine concentrations between the two diagnostic groups, the highest values being obtained in the group of subjects with a previous diagnosis of diabetes mellitus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140050249
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Usefulness of myosin in the postmortem diagnosis of myocardial damage (1995)
    Springer
    International journal of legal medicine 108 (1995), S. 14-18 
    Details
    ISSN: 1437-1596
    Keywords: Myocardial ischaemia ; Biochemistry Myosin ; Postmortem ; Pericardial fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract In some situations the postmortem diagnosis of myocardial infarction is made difficult by the brief course of the fatal episode or by interferences caused by autolysis. In such cases, biochemical indices may provide a useful adjunct to morphological studies. Myosin is the main component of the contractile apparatus of muscle cells, so its determination may well be useful to evaluate myocardial injury. The purpose of the present study was to establish the diagnostic efficacy of postmortem myosin heavy chain determinations using monoclonal antibodies and to compare this data with structural findings used to diagnose acute myocardial ischaemia. We studied 105 cadavers with a mean age of 61.63 ± 2.21 years. Cases were allocated to 1 of 7 diagnostic groups depending on the probable intensity of myocardial damage and cause of death. The highest serum and pericardial fluid values of myosin heavy chains were seen in subjects who showed morphological evidence of myocardial ischaemia. Mean pericardial fluid/serum ratios differed significantly between subjects with and without observable signs of heart damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01845610
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Cardiac troponin I (cTn I) and the postmortem diagnosis of myocardial infarction (1998)
    Springer
    International journal of legal medicine 111 (1998), S. 173-176 
    Details
    ISSN: 1437-1596
    Keywords: Key words Myocardial ischaemia ; Biochemistry ; Troponin ; Postmortem ; Pericardial fluid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract In clinical practice several biochemical markers are used for the diagnosis of myocardial infarction. Because of its extremely high specificity for myocardial damage, cardiac troponin I (cTn I) is frequently used. The aim of this study was to evaluate the diagnostic efficacy of postmortem cTn I determinations in pericardial fluid and serum and to compare these results with other biochemical markers and with structural findings used to diagnose acute myocardial ischaemia. We studied 89 cadavers with a mean age of 51.38 ± 2.04 (SD 19.27 years). Cases were allocated to 1 of 4 diagnostic groups depending on the probable intensity of myocardial damage and cause of death. In pericardial fluid we obtained statistically significant differences for the four biochemical parameters, while in serum myosin heavy chains and myoglobin showed statistically significant differences. The highest levels of biochemical markers in pericardial fluid were observed in subjects who had died from definite myocardial infarction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140050143
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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