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  • Hippocampus  (1)
  • Key words: Tiludronate—Osteoporosis—Ovariectomy—Bone mineralization—High resolution TEM—Ultrastructural characterization.  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Selective vulnerability in the gerbil hippocampus: Morphological changes after 5-min ischemia and long survival times (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 18-25 
    Details
    ISSN: 1432-0533
    Keywords: Ischemia ; Hippocampus ; Resistant neurons ; Recirculation time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The morphology of the hippocampus of Mongolian gerbils was investigated by light and electron microscopy after 5-min forebrain ischemia and survival times of up to 10 months. After 3 weeks recirculation only 5.8% of pyramidal neurons of the CA1 (cornu ammonis 1) sector had survived but the thickness of the inner and outer hippocampal layers did not change. After recirculation times of 6 and 10 months the number of surviving neurons declined no further but all layers of the CA1 subfield shrank markedly. Ultrastructurally, many but not all surviving CA1 neurons were altered. After 3 weeks both “dark” and “pale” type neurons were present, while after 6 and 10 months only the “pale” type of injury persisted. Axonal enlargements and myelin breakdown were observed at all survival times up to 10 months of recirculation. The astrocytes of CA1 sector contained numerous glial fibrils which were most pronounced after the longer recirculation times. The stratum radiatum presented intact presynaptic terminals densely packed with an abundance of clear vesicles even after survival of 10 months. Initially, morphologically damaged postsynaptic structures were still attached to these terminals but they disappeared after longer recirculation times. However, even after 10 months some intact synapses were observed involving dendrites which probably originated from surviving CA1 neurons. In CA3 sector and dentate gyrus no ultrastructural changes occurred at any survival time. The close association of surviving CA1 neurons with intact presynaptic terminals and reactive glial cells may be of importance for the development of epileptogenic foci which are characteristic of this particular brain region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294217
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructural Properties of Bone Mineral of Control and Tiludronate-Treated Osteoporotic Rat (2000)
    Springer
    Calcified tissue international 67 (2000), S. 330-336 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Tiludronate—Osteoporosis—Ovariectomy—Bone mineralization—High resolution TEM—Ultrastructural characterization.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Bisphosphonates have been widely used in the treatment of human bone pathologies including osteoporosis. In this case, bisphosphonates have been shown to reduce bone resorption, thereby increasing the mass and mechanical resistance of bone. Determining the effects of these molecules on the properties of the bone apatite crystals could provide a better insight into the mechanism of bisphosphonate/bone interaction. The aim of this study was to determine the ultrastructural effects of a third generation bisphosphonate (tiludronate) on the morphology, size, distribution, chemical composition, and structure of apatite crystals in bone (trabecular) in a rat osteoporotic model. Four groups of rats were studied: (1) sham operated, (2) untreated ovariectomized (OVX), (3) OVX rats which received 35 mg/kg of tiludronate, (4) OVX rats which received 160 mg/kg of tiludronate. The rats of groups 3 and 4 received tiludronate orally in 2 consecutive days every week for 1 year. Scanning electron microscopy (SEM), high and low resolution transmission electron microscopy (TEM), and electron microprobe analysis (EDX) were used for the ultrastructural characterization of the bone mineral. This study demonstrated that tiludronate slightly increased the width of bone apatite crystals without changing any other crystal characteristics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002230001141
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    Paper (German National Licenses)
    Fulltext
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