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  • 1
    Electronic Resource
    Electronic Resource
    Synchrotron hard x-ray microprobe: Fluorescence imaging of single cells (2001)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 78 (2001), S. 3544-3546 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Imaging of trace elements in single cells was achieved by synchrotron-induced x-ray fluorescence (SXRF) in the hard x-ray range. Monochromatic and "pink" excitations at 14 keV were used with compound refractive lenses resulting in a 1×10 μm2 beam size. The experiment shows that SXRF is well suited for microanalysis of freeze-dried cells, and demonstrated high accuracy in quantitative imaging of trace element in cells treated with pharmacological doses of an iodine-labeled anticancer drug. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1366362
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  • 2
    Electronic Resource
    Electronic Resource
    Determination of trace elements in Parkinson's diseased brain tissue using microbeam of synchrotron radiation (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 85 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The microbeam synchrotron X-ray fluorescence (MSXRF) technique is powerful tool for determining elemental composition and spatial distribution of elements within materials on the microscopic level. Therefore, application of this technique seems to be helpful for investigation of the role of trace elements in neurodegenerative processes. As a preliminary study the MSXRF technique was applied for elemental microanalysis in cryo-sections of substantia nigra tissue for cases of Parkinson's disease (PD) and the control. Two-dimensional maps of elemental distribution showed significant topographic and quantitative differences between the pathological and control tissues. Quite interesting is significant increased accumulation of Ca, Cu, Fe, Fe, and Zn that was observed in PD neuron perikaryal parts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.85.s2.17_5.x
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  • 3
    Electronic Resource
    Electronic Resource
    Alteration of zinc accumulation in ageing and neurodegenerative disorders (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 85 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The X-ray fluorescence techniques were applied for study of Zn accumulation in CNS tissue. Concentration of this element was determined in white and gray matter of the brains without any neurodegeneration processes with respect to ageing. Significant increase of Zn accumulation with age was observed in white matter. As is supposed, Zn may also play an important role in neurodegeneration. Topographic and quantitative analysis of this element was performed for Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). The study was performed in tissue slices taken from substantia nigra (SN) and spinal cord. The results showed that accumulation of Zn in PD neurones of SN is significantly increased in comparison with the control, meanwhile degenerated motor neurones of spinal cord in ALS reveal decreased level of Zn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.85.s2.29.x
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructural Properties of Bone Mineral of Control and Tiludronate-Treated Osteoporotic Rat (2000)
    Springer
    Calcified tissue international 67 (2000), S. 330-336 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Tiludronate—Osteoporosis—Ovariectomy—Bone mineralization—High resolution TEM—Ultrastructural characterization.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Bisphosphonates have been widely used in the treatment of human bone pathologies including osteoporosis. In this case, bisphosphonates have been shown to reduce bone resorption, thereby increasing the mass and mechanical resistance of bone. Determining the effects of these molecules on the properties of the bone apatite crystals could provide a better insight into the mechanism of bisphosphonate/bone interaction. The aim of this study was to determine the ultrastructural effects of a third generation bisphosphonate (tiludronate) on the morphology, size, distribution, chemical composition, and structure of apatite crystals in bone (trabecular) in a rat osteoporotic model. Four groups of rats were studied: (1) sham operated, (2) untreated ovariectomized (OVX), (3) OVX rats which received 35 mg/kg of tiludronate, (4) OVX rats which received 160 mg/kg of tiludronate. The rats of groups 3 and 4 received tiludronate orally in 2 consecutive days every week for 1 year. Scanning electron microscopy (SEM), high and low resolution transmission electron microscopy (TEM), and electron microprobe analysis (EDX) were used for the ultrastructural characterization of the bone mineral. This study demonstrated that tiludronate slightly increased the width of bone apatite crystals without changing any other crystal characteristics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002230001141
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  • 5
    Electronic Resource
    Electronic Resource
    Application of FT-IR microspectroscopy to the study of an injectable composite for bone and dental surgery (1998)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 41 (1998), S. 167-170 
    Details
    ISSN: 0021-9304
    Keywords: FT-IR ; microspectroscopy ; infrared ; injectable biomaterial ; calcium phosphate ; bone substitute ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Hydroxypropylmethylcellulose (HPMC) of high-viscosity grade is used as a ligand for a bioactive calcium phosphate ceramic (the filler) in a ready-to-use injectable sterilized biomaterial for bone and dental surgery. Application of physico-chemical methods such as XPS, NMR, or Raman spectroscopy encounters difficulties when used to study such a multiphased material. This paper reports on the application of FT-IR microspectroscopy (FT-IRM) for the investigation of inorganic and organic phases of the rough composite and separated phases obtained by mechanical or chemical extraction methods. A comparison of FT-IRM with the conventional KBr pellet method was made and indicates that the macro and micro FT-IR methods are complementary: the former revealed new chemical groups not visualized with the KBr method whereas the latter detected the major compound of the blend. FT-IR microspectroscopy was revealed to be a powerful method of analysis that is complementary to other existing spectroscopic methods. Moreover, it is expected to be a useful tool in the study of biomaterials in biological samples. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 167-170, 1998.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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