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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 25 (1983), S. 231-234 
    ISSN: 1432-0428
    Keywords: Epidemiology ; insulin-treated diabetes ; prevalence ; heterogeneity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report the clinical characteristics of all insulin-treated diabetic patients (783 males and 716 females) living on July 11973 in a Danish county. In 18 patients diabetes was believed to be secondary to another disease or condition. Of all patients, 43% of the males and 55% of the females were 〉 age 50 years and 42% and 36% of males and females, respectively, had a disease duration of 〈 10 years. The overall proportion of patients treated permanently with insulin from diagnosis was 85% and 79% in males and females, respectively, but within the subgroup of patients with current age 〈 30 years these proportions were 99% and 96%, respectively. Statistical analysis indicated that insulin-treated diabetes is a clinically heterogeneous group of diseases; thus, low age at onset combined with immediate and permanent insulin treatment delineate one subtype, while relatively high age at onset and late start and/or interruption of insulin treatment delineate other subtype(s). It is estimated that the proportion of patients with truly Type 1 (insulin-dependent) diabetes is 〉 50% in this cross-sectional population of insulin-treated patients.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 37 (1994), S. 321-327 
    ISSN: 1432-0428
    Keywords: IDDM ; first-degree relatives ; familial aggregation ; recurrence risk ; life-table analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Due to a short observation period previous studies may have underestimated prevalence and recurrence risk of IDDM in relatives of IDDM patients. To obtain a more exact life-time risk estimate we identified 310 probands, representative of Danish IDDM patients, characterized by current age more than 50 years, age at onset 40 years or less and diabetes duration of more than 30 years. Family data were obtained from 291 probands. Mean “observation” times (age) (± SD) for siblings (n = 553) and offspring (n=359) were 59.4 ± 16.1 years and 33.8 ± 8.8 years, respectively. Of the probands 73 (25.1%) had at least one first-degree relative with IDDM. Seventeen percent had at least one affected sibling. An increase from 10.4% to 22.4% of having first-degree relatives with IDDM among probands with age at onset below 20 years was observed during the period from proband at age 21 years up to 1 September 1992. Among affected siblings 48% of the second cases were affected more than 10 years after the first affected sibling. Using the life-table method cumulative recurrence risks from time of birth were calculated for siblings up to age 30 years of 6.4% and up to age 60 years of 9.6%. For offspring the risk up to age 34 years was 6.3%. In addition, we present a life-table method evaluating the cumulative recurrence risk from time of onset in the proband, as this is the most relevant when giving genetic counselling. In conclusion, the long-term risks of IDDM in siblings and offspring are high compared to that shown in previous reports.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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