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  • 1
    Electronic Resource
    Electronic Resource
    Additions and Corrections - Condensations by Sodium. XXV. Reactions of Amylsodium with Naphthalene, Acenaphthene and Decalin (1942)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 64 (1942), S. 3073-3073 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01264a633
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  • 2
    Electronic Resource
    Electronic Resource
    Condensations by Sodium. XXV. Reactions of Amylsodium with Naphthalene, Acenaphthene and Decalin (1942)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 64 (1942), S. 2250-2253 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01262a005
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    DEMETHYLTERACYCLINES. SYNTHESIS OF A DEGRADATION PRODUCT (1957)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 79 (1957), S. 4564-4564 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01573a091
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  • 4
    Electronic Resource
    Electronic Resource
    Relative mortality of Type 1 (insulin-dependent) diabetes in Denmark: 1933–1981 (1985)
    Springer
    Diabetologia 28 (1985), S. 339-342 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; mortality ; regression analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relative mortality of Type 1 (insulin-dependent) diabetes in Denmark during the period 1933–1981 was studied using a modification of Cox's regression model on the basis of two patient populations, ascertained in different ways and independently of each other. Initial analysis showed that the two groups could be combined completely into one common analysis. Relative mortality was the same for both sexes. The additional variables studied were age at diagnosis, current age, calendar year at diagnosis and calendar time during follow-up. All these interrelated variables were accounted for in the analysis. The analysis showed that relative mortality (a) decreased with increasing age at diagnosis; (b) increased from 1933 to a maximum in about 1965, after which it decreased; (c) increased with increased duration of diabetes to a maximum at 15–25 years, after which it declined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00283140
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  • 5
    Electronic Resource
    Electronic Resource
    Epidemiological studies of diabetes mellitus in Denmark (1981)
    Springer
    Diabetologia 20 (1981), S. 468-470 
    Details
    ISSN: 1432-0428
    Keywords: Prevalence ; insulin-treated diabetes mellitus ; prescriptions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The study aimed at tracing the population of insulin-treated diabetics living in the Funen County, Denmark (approximately 450 000 inhabitants) on 1 July 1973. It was based on a recording of insulin prescriptions among all prescriptions handled by the pharmacies in Funen County during a fivemonth period. Through information from medical records and public registries the verification of the diagnosis and the identity of the insulin prescription holders were checked, and it is estimated that the completeness of the study material was above 98%. Age- and sex-specific prevalence rates of insulin-treated diabetes mellitus were calculated. The overall prevalence rate for males was 3.6 per 1,000 and that for females 3.3 per 1,000.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253409
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  • 6
    Electronic Resource
    Electronic Resource
    Frequency of cancer among insulin-treated diabetic patients in Denmark (1985)
    Springer
    Diabetologia 28 (1985), S. 128-130 
    Details
    ISSN: 1432-0428
    Keywords: Cancer ; diabetes mellitus ; epidemiology ; registry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The total prevalent population of insulin-treated diabetic subjects (1499 patients) in Fyn County, Denmark, was followed for 8 1/2 years (beginning 1 July 1973). All cases of cancer diagnosed during this period were identified by a record cross-check with the Danish Cancer Registry. In total, 45 and 37 cancer cases were identified among male and female patients, respectively, corresponding with observed/expected ratios of 1.37 (p = 0.03) and 1.08 (p = 0.65), respectively. Specified for site, a significant excess of cancer of the pancreas was found (six cases observed vs 2.4 expected, p = 0.02), but the excess was reduced by excluding cases where the cancer patient had diabetes as an early sign. Overall, no indications were found of an association between diabetes and cancer, whether in general or regarding particular cancer types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273858
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  • 7
    Electronic Resource
    Electronic Resource
    Epidemiological studies of diabetes mellitus in Denmark (1980)
    Springer
    Diabetologia 19 (1980), S. 355-358 
    Details
    ISSN: 1432-0428
    Keywords: Epidemiology ; early onset diabetes mellitus ; conscript registries ; death certificates ; incidence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To provide unbiased material for epidemiological studies of diabetes mellitus a case finding method based on the Danish National Service Conscript Registry and death certificates is presented and discussed. Eight Danish total male birth cohorts, totalling 320162 persons, have been observed as to the occurrence of diabetes mellitus during the first twenty years of life, and it is concluded that the conscript registry represents an ideal basis for case identification, if the individual cases are further elucidated. he material is estimated to be about 95% complete. The main source of error originates from omissions when the registries are scrutinized. The cumulative incidence rates for the birth cohorts range from 1.3 to 3.2 per thousand; in the total material 2.4 per thousand.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280520
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  • 8
    Electronic Resource
    Electronic Resource
    HLA-D and -DR antigens in genetic analysis of insulin dependent diabetes mellitus (1981)
    Springer
    Diabetologia 21 (1981), S. 108-115 
    Details
    ISSN: 1432-0428
    Keywords: HLA ; genetics ; heterogeneity of insulin-dependent diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three groups of patients with insulin-dependent diabetes mellitus, ascertained by different procedures, were investigated for HLA-A, B, C and D antigens (n=164), and a subset (n=93) for HLA-DR. Both HLA-D/DR3 and D/DR4 were strongly positively associated and D/DR2 was negatively associated with insulin-dependent diabetes. HLA-DR4 was found to be a better marker for insulin-dependent diabetes than Dw4. The HLA-B associations (B8, B15 and B18) were clearly secondary to the increases of HLA-D/DR3 and D/DR 4. The HLA associations did not differ between familial and isolated cases indicating that these two groups may well have a common genetic background. Based on analysis of HLA-haplotype sharing in affected sibling pairs, a simple dominant model of inheritance could be ruled out, and a simple recessive model was found unlikely. The relative risks for the HLA-Dw3,4 and HLA-DR3,4 phenotype were 21.2 and 44.4 respectively and exceeded those of both the HLA-Dw3 and HLA-DR3 (5.6 and 4.3) as well as the HLA-Dw4 and DR4 (10.1 and 10.5) phenotypes. This argues against an intermediate genetic model but further studies are needed to clarify whether there is more than one susceptibility gene for insulin-dependent diabetes mellitus within the HLA-system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251276
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  • 9
    Electronic Resource
    Electronic Resource
    Effects of prednisolone and dexamethasone in vivo and in vitro: Studies of insulin binding, deoxyglucose uptake and glucose oxidation in rat adipocytes (1981)
    Springer
    Diabetologia 21 (1981), S. 149-153 
    Details
    ISSN: 1432-0428
    Keywords: Insulin ; adipocytes ; prednisolone ; dexamethasone ; insulin binding ; deoxyglucose transport ; glucose oxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have studied the effects of dexamethasone and prednisolone in vitro and in vivo on insulin binding, deoxyglucose uptake and glucose oxidation in rat adipocytes. In the studies in vivo, rats were treated for 22 h with dexamethasone (30 μg/kg) or prednisolone (200 μg/kg). Following sacrifice, adipocytes were prepared and the results demonstrated that cells from prednisolone treated rats showed a 17% increase in insulin binding and increased rates of basal and insulin stimulated deoxyglucose uptake and glucose oxidation. Conversely, dexamethasone administration resulted in a 22% decrease in insulin binding, and decreased rates of deoxyglucose uptake and glucose oxidation by the cells. Thus, prednisolone and dexamethasone had opposite effects in vivo. In contrast to the opposite effects of the two glucocorticoids in vivo, dexamethasone and prednisolone (each at a concentration of 1 μmol/l) had similar effects on adipocytes in vitro. Incubation of adipocytes with the steroids did not alter insulin binding, while both agents led to a comparable decrease in the rates of basal and insulin stimulated deoxyglucose uptake and glucose oxidation. Thus, dexamethasone and prednisolone have opposite effects on adipocyte glucose metabolism in vivo but have similar effects in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251283
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  • 10
    Electronic Resource
    Electronic Resource
    Epidemiological studies of diabetes mellitus in Denmark: 5. Mortality and causes of death among insulin-treated diabetic patients (1984)
    Springer
    Diabetologia 26 (1984), S. 190-194 
    Details
    ISSN: 1432-0428
    Keywords: Insulin-treated diabetes ; mortality ; regression analysis ; death certificates ; causes of death
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 7-year follow-up study is reported on the prevalent population of all insulin-treated diabetic patients (n=1499) as of 1 July 1973 in the Funen County, Denmark. The analysis of mortality was based on data from 395 dead and the remaining 1104 living patients. Males had a significantly higher mortality than females and a lower age at onset was associated with a significantly higher mortality. An analysis of the causes of death revealed a higher than expected number of deaths in all categories studied, although the excess mortality was highest for diabetes mellitus itself and cardiovascular diseases. Diabetes mellitus was not notified on 15% of the death certificates, and this under-reporting varied according to duration of the disease and place of death. It is concluded that studies based solely on death certificates will underestimate the mortality of diabetes mellitus, and that further longitudinal studies of well-defined, population-based patient groups are needed to evaluate the determinants of mortality in diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252405
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