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  • 1
    Electronic Resource
    Electronic Resource
    Epidemiological studies of diabetes mellitus in Denmark (1981)
    Springer
    Diabetologia 20 (1981), S. 468-470 
    Details
    ISSN: 1432-0428
    Keywords: Prevalence ; insulin-treated diabetes mellitus ; prescriptions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The study aimed at tracing the population of insulin-treated diabetics living in the Funen County, Denmark (approximately 450 000 inhabitants) on 1 July 1973. It was based on a recording of insulin prescriptions among all prescriptions handled by the pharmacies in Funen County during a fivemonth period. Through information from medical records and public registries the verification of the diagnosis and the identity of the insulin prescription holders were checked, and it is estimated that the completeness of the study material was above 98%. Age- and sex-specific prevalence rates of insulin-treated diabetes mellitus were calculated. The overall prevalence rate for males was 3.6 per 1,000 and that for females 3.3 per 1,000.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253409
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  • 2
    Electronic Resource
    Electronic Resource
    Epidemiological studies of diabetes mellitus in Denmark (1980)
    Springer
    Diabetologia 19 (1980), S. 355-358 
    Details
    ISSN: 1432-0428
    Keywords: Epidemiology ; early onset diabetes mellitus ; conscript registries ; death certificates ; incidence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To provide unbiased material for epidemiological studies of diabetes mellitus a case finding method based on the Danish National Service Conscript Registry and death certificates is presented and discussed. Eight Danish total male birth cohorts, totalling 320162 persons, have been observed as to the occurrence of diabetes mellitus during the first twenty years of life, and it is concluded that the conscript registry represents an ideal basis for case identification, if the individual cases are further elucidated. he material is estimated to be about 95% complete. The main source of error originates from omissions when the registries are scrutinized. The cumulative incidence rates for the birth cohorts range from 1.3 to 3.2 per thousand; in the total material 2.4 per thousand.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280520
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  • 3
    Electronic Resource
    Electronic Resource
    HLA-D and -DR antigens in genetic analysis of insulin dependent diabetes mellitus (1981)
    Springer
    Diabetologia 21 (1981), S. 108-115 
    Details
    ISSN: 1432-0428
    Keywords: HLA ; genetics ; heterogeneity of insulin-dependent diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three groups of patients with insulin-dependent diabetes mellitus, ascertained by different procedures, were investigated for HLA-A, B, C and D antigens (n=164), and a subset (n=93) for HLA-DR. Both HLA-D/DR3 and D/DR4 were strongly positively associated and D/DR2 was negatively associated with insulin-dependent diabetes. HLA-DR4 was found to be a better marker for insulin-dependent diabetes than Dw4. The HLA-B associations (B8, B15 and B18) were clearly secondary to the increases of HLA-D/DR3 and D/DR 4. The HLA associations did not differ between familial and isolated cases indicating that these two groups may well have a common genetic background. Based on analysis of HLA-haplotype sharing in affected sibling pairs, a simple dominant model of inheritance could be ruled out, and a simple recessive model was found unlikely. The relative risks for the HLA-Dw3,4 and HLA-DR3,4 phenotype were 21.2 and 44.4 respectively and exceeded those of both the HLA-Dw3 and HLA-DR3 (5.6 and 4.3) as well as the HLA-Dw4 and DR4 (10.1 and 10.5) phenotypes. This argues against an intermediate genetic model but further studies are needed to clarify whether there is more than one susceptibility gene for insulin-dependent diabetes mellitus within the HLA-system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251276
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  • 4
    Electronic Resource
    Electronic Resource
    Metacarpal morphometry in monozygotic and dizygotic elderly twins (1978)
    Springer
    Calcified tissue international 25 (1978), S. 197-201 
    Details
    ISSN: 1432-0827
    Keywords: Metacarpals ; Bone morphometry ; Twins ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The relative importance of genetic factors in the pathogenesis of age related bone loss has been investigated in a study involving 17 monozygotic (MZ) and 8 dizygotic (DZ) pairs of twins aged 64 to 75 years. Radiographic morphometry was performed at the midpoints of the 2nd, 3rd and 4th metacarpals of both hands and the mean total and cortical widths were evaluated. The heritability, h2, was calculated as the difference between the intrapair variances in same sexed DZ and MZ pairs divided by the intrapair variance in DZ pairs. The mean intrapair variance of both total and cortical width was found to be four to five times higher in DZ than in MZ pairs. The differences are highly significant with an h2 value between 0.7 and 0.8, indicating a predominant genetic influence. It is stressed that this result applies only to the population from which the twin sample was drawn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010768
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  • 5
    Electronic Resource
    Electronic Resource
    Genetics of the Human HL-A Transplantation System (1968)
    [s.l.] : Nature Publishing Group
    Nature 219 (1968), S. 1116-1119 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Genetic and statistical analyses indicate that the HL-A system contains two intimately related chromosome regions containing at least seven and eight alleles, respectively. The complex antibodies which these regions give rise to consist of a mixture of smaller ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2191116a0
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Blood groups, serum proteins and enzymes of the faroe Islanders
    Amsterdam : Elsevier
    Journal of Human Evolution 14 (1985), S. 725-738 
    Details
    ISSN: 0047-2484
    Keywords: Faroes ; blood groups ; enzymes ; genetic distance ; polymorphism ; proteins
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0047-2484(85)80055-5
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  • 7
    Electronic Resource
    Electronic Resource
    Blood groups, serum proteins and enzymes of the faroe Islanders
    Amsterdam : Elsevier
    Journal of Human Evolution 14 (1985), S. 725-738 
    Details
    ISSN: 0047-2484
    Keywords: Faroes ; blood groups ; enzymes ; genetic distance ; polymorphism ; proteins
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0047-2484(85)80055-5
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  • 8
    Electronic Resource
    Electronic Resource
    The value of fluorescence markers in the distinction between maternal and fetal chromosomes (1975)
    Springer
    Human genetics 〈Berlin〉 26 (1975), S. 187-191 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Selected fluorescence markers of chromosomes were studied in 50 paired samples of cells obtained by culture of amniocentesis material and by culture of leukocytes from pregnant women. Comparative analyses showed that this method is of great value in disclosing admixture of maternal cells to material obtained by amniocentesis, as a minimum of 2 fluorescence marker differences between mother and fetus was found in the present material. The distribution of markers in mother/fetus pairs is in agreement with the assumption of genetic determination. Variation was observed between populations with respect to the frequency of the markers studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00281452
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  • 9
    Electronic Resource
    Electronic Resource
    A cohort study of neural tube defects (NTD) in Denmark covering the first seven years of life (1987)
    Springer
    Child's nervous system 3 (1987), S. 117-120 
    Details
    ISSN: 1433-0350
    Keywords: Spina bifida ; Neural tube defects ; Epidemiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the County of Fyn, Denmark, which is a well-delimited region comprising a 10% representative sample of the total population, ten complete one year cohorts of newborn were scrutinized for neural tube defects (NTD). Among 66,000 births, 71 cases with NTD were observed. The total prevalence at birth was 1.08/1,000; 0.29 for anencephaly; 0.20 for encephalocele, and 0.59 for spina bifida (SB). This is at the same level as in other Scandinavian countries. Considering only neonates born alive, 57% of the total survived until the age of 7 years, disregarding anencephaly, but only 4 of 18 SB cases and 6 of 11 encephalocele cases had no handicaps at age 7. On the average, SB patients spent 9% of their life before the age of 7 years in hospitals and encephaloceles 2%. The SB cases occupied 25 times more beds per year than the comparable age group in general and many were likely to need continued medical and social care.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00271138
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  • 10
    Electronic Resource
    Electronic Resource
    Two-parameter characterization of the near-tip stress fields for a bi-material elastic-plastic interface crack (1996)
    Springer
    International journal of fracture 79 (1996), S. 65-83 
    Details
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A particular case of interface cracks is considered. The materials at each side of the interface are assumed to have different yield strength and plastic strain hardening exponent, while elastic properties are identical. The problem is considered to be a relevant idealization of a crack at the fusion line in a weldment. A systematic investigation of the mismatch effect in this bi-material plane strain mode I dominating interface crack has been performed by finite strain finite element analyses. Results for loading causing small scale yielding at the crack tip are described. It is concluded that the near-tip stress field in the forward sector can be separated, at least approximately, into two parts. The first part is characterized by the homogeneous small scale yielding field controlled by J for one of the interface materials, the reference material. The second part which influences the absolute value of stresses at the crack tip and measures the deviation of the fields from the first part can be characterized by a mismatch constraint parameter M. Results have indicated that the second part is a very weak function of distance from the crack tip in the forward sector, and the angular distribution of the second part is only a function of the plastic hardening property of the reference material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00017713
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