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  • 1
    Electronic Resource
    Electronic Resource
    Symptoms, diagnosis, and therapy of neuronal intestinal dysplasia masked by Hirschsprung's disease (1987)
    Springer
    Pediatric surgery international 2 (1987), S. 76-80 
    Details
    ISSN: 1437-9813
    Keywords: Neuronal intestinal dysplasia ; Hirschsprung's disease ; Colon sonography ; Colon motility ; Colon biopsy, diagnostic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-four cases of concomitant Hirschsprung's disease (HD) and neuronal intestinal dysplasia (NID) are presented. The clinical picture is characterized by the early and acute onset of HD symptoms. The diagnosis is established by means of rectal and colonic biopsies. Open biopsies during laparotomy should be taken without injury to the mucosa. Early surgical therapy consists of extended resection of the aganglionic segment and the colon affected by NID up to the splenic flexure. Complications are imminent if the aganglionosis masks the symptoms of NID and, accordingly, only the aganglionic segment is resected. As an alternative, postponed resection of the aganglionic segment alone is proposed once the NID-affected bowel develops functional maturation. In children who do not show an improvement of colon dysmotility, however, extended resection is recommended at the age of 4 years. In follow-up studies of colon motility, functional colon sonography is used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174177
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Neuronal intestinal dysplasia (1987)
    Springer
    Pediatric surgery international 2 (1987), S. 352-358 
    Details
    ISSN: 1437-9813
    Keywords: Neuronal intestinal dysplasia ; Colon motility ; Colon sonography ; Colostomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Findings in 23 children with neuronal intestinal dysplasia (NID) are presented. Twelve children had Hirschsprung's disease that masked the existence of proximal NID. In all cases the diagnosis was established by histological-histochemical examination. Amelioration of symptoms by conservative treatment alone was achieved in 4 children; in 13 cases colostomy was necessary. In 6 patients colon resection was performed: 2 suffered from both colitis and obstruction; the other 4 were treated for obstruction, multiple perforations, persistant adynamia of the left colon, and fistulation. In 9 patients the colostomy was closed. Four of 6 children who did not have sonographic confirmation of motility had complications due to colon dysmotility after closure of their normally functioning colostomy. Therapeutic measures are based exclusively on clinical and functional parameters. The clinical picture dictates the emergency measures (colostomy, colon resection, and colectomy). Normal colostomy function is not a sufficient criterion of normal colon motility. Functional sonography of the colon is included in the planning of further therapy. Indications, timing, and extent of colon resection can be reliably determined using the sonographic method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175648
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Cell types infected in human cytomegalovirus placentitis identified by immunohistochemical double staining (1993)
    Springer
    Virchows Archiv 423 (1993), S. 249-256 
    Details
    ISSN: 1432-2307
    Keywords: Cytomegalovirus ; Congenital cytomegalic inclusion disease ; Placenta ; Chorionic villi ; Immuno histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chronic villitis is almost always present in intrauterine infection with human cytomegalovirus (HCMV). The inflammatory response to this virus has been described in detail. However, little is known about the types of placental cells that may be infected by HCMV and six cases of HCMV placentitis were thus investigated to identify the vulnerable cell types. Immunohistochemical double staining analyses were performed using antibodies to HCMV immediate early antigens and to specific cellular marker proteins. Fixed connective tissue cells could be demonstrated to be the predominantly infected cell type in each placental tissue. Endothelial cells and macrophages were also found to be infected in all six cases, whereas evidence of trophoblast infection was obtained in four cases. It is concluded that release of infectious virus by connective tissue cells, macrophages and endothelial cells may play a critical role in transplacental transmission of HCMV. The findings further suggest that the cytopathic effect of HCMV infection on these cells might be involved in the pathogenesis of intrauterine HCMV disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606887
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    Paper (German National Licenses)
    Fulltext
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