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  • central nervous system tumors  (2)
  • Immunohistochemistry  (1)
  • Loss of heterozygosity  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Deletions on the long arm of chromosome 17 in pilocytic astrocytoma (1993)
    Springer
    Acta neuropathologica 86 (1993), S. 81-85 
    Details
    ISSN: 1432-0533
    Keywords: Pilocytic astrocytoma ; Loss of heterozygosity ; Chromosome 17 ; Tumor suppressor gene ; Neurofibromatosis type 1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pilocytic astrocytomas are the most common astrocytic tumors of childhood and differ clinically and histopathologically from those astrocytomas that affect adults. Studies of adult astrocytic tumors have revealed allelic losses on chromosomes 10, 17p, 19q and alterations in the epidermal growth factor receptor (EGFR) gene. We have previously examined pilocytic astrocytomas for allelic losses on chromosomes 10 and 19q and for amplification of the EGFR gene, but did not detect genomic alterations at these loci. In the present study we assayed 20 pilocytic astrocytomas for loss of allelic heterozygosity of chromosome 17p, including one locus in the p53 tumor suppressor gene. In addition, because pilocytic astrocytomas frequently affect patients with neurofibromatosis type 1 (NF1) and the NF1 gene has been mapped to 17q11.2, we also examined multiple loci on the long arm of chromosome 17. Allelic loss was observed on chromosome 17 in four cases (three sporadic, one NF1); all lost portions of the long arm in chromosome 17, and one tumor lost the short arm as well. One tumor showed an interstitial delection on the long arm that included the region of the NF1 gene. These data suggest the presence of a tumor suppressor gene on 17q that is associated with pilocytic astrocytomas. A potentiel candidate for this gene is the NF1 tumor suppressor gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454903
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  • 2
    Electronic Resource
    Electronic Resource
    Accumulation of wild-type p53 in astrocytomas is associated with increased p21 expression (1997)
    Springer
    Acta neuropathologica 94 (1997), S. 21-27 
    Details
    ISSN: 1432-0533
    Keywords: Key words p21 ; p53 ; Astrocytoma ; Single-strand ; conformation polymorphism ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Approximately one quarter of human astrocytomas show immunohistochemical positivity for p53 protein but lack p53 gene mutations, which could reflect either an accumulation of wild-type p53 protein or an inadequate sensitivity of mutation detection. Since wild-type p53 up-regulates p21 expression, increased p21 expression in those astrocytomas with p53 accumulation in the absence of mutations would argue that the protein was wild type in these tumors. We therefore compared p21 expression with p53 gene and protein status in 48 primary human astrocytomas. Single-strand conformation polymorphism analysis and direct sequencing of the p53 gene showed mutations in 11 tumors (22.9%), while immunohistochemistry revealed positive staining in 19 cases (39.6%). Those tumors with p53 immunopositivity in the absence of p53 mutation had significantly increased p21 expression when compared to either mutant p53 or p53-immunonegative cases. Neither p53 nor p21 status correlated with proliferation indices, as assessed by Ki-67 immunohistochemistry. These results support the hypotheses that functionally wild-type p53 accumulates in some astrocytomas, and that alternative cell cycle checkpoints (such as the p16 pathway) may be more important than p21 in regulating proliferation in astrocytomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050667
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Cerebral primitive neuroectodermal tumor in an adult, with spinal cord metastasis after 18-year dormancy (1990)
    Springer
    Journal of neuro-oncology 9 (1990), S. 77-80 
    Details
    ISSN: 1573-7373
    Keywords: primitive neuroectodermal tumor ; neuroblastoma ; central nervous system tumors ; metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A cerebral primitive neuroectodermal tumor in a 40-year-old man recurred as a metastasis to the spinal cord after an 18-year dormant period. The metastatic tumor showed features of neuronal differentiation. The clinical course and pathologic findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167072
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Central nervous system neurocytoma and neuroblastoma in adults-report of eight cases (1990)
    Springer
    Journal of neuro-oncology 9 (1990), S. 231-238 
    Details
    ISSN: 1573-7373
    Keywords: neuroblastoma ; neurocytoma ; central nervous system tumors ; spinal cord tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical features, pathologic findings and treatment courses of eight adults with central nervous system small-cell neuronal tumors were reviewed. Five patients had central neurocytomas, two patients central nervous system neuroblastomas, and one patient a neurocytoma-like spinal cord tumor. The neurocytomas were intraventricular, moderately cellular tumors with bland nuclei and perinuclear halos. Patients with neurocytoma were treated with surgery, radiation therapy, and/or chemotherapy, and have followed favorable clinical courses. The neuroblastomas were intraparenchymal, hypercellular tumors with necrosis and frequent mitoses. Patients with neuroblastomas were treated with surgery, radiation therapy and chemotherapy, with some clinical response, but overall poor survival. One of the two patients developed extracranial metastasis. The spinal cord tumor had histologic features of neurocytoma, and responded well to biopsy and radiation therapy. The cases are compared with the varieties of small-celled neuronal tumors described in the literature, and pathologic, histogenetic and treatment implications are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02341154
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    Paper (German National Licenses)
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