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  • 1
    Electronic Resource
    Electronic Resource
    Lithium potassium borate and lithium rubidium borate: new non-linear optical crystals (2000)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 56 (2000), S. 1413-1415 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The title compounds, LiKB4O7 and LiRbB4O7, are newly developed non-linear optical crystals containing two kinds of anionic groups, namely (B3O8)7− and (B5O10)5−. The (B3O8)7− groups form infinite spiral chains parallel to the [100] direction, which are interconnected by sharing O atoms with (B5O10)5− groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270100013445
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  • 2
    Electronic Resource
    Electronic Resource
    Superconductivity in the tetragonal phase of La1.9Bi0.1CuO4+δ annealed under high oxygen pressure (1994)
    Springer
    Journal of superconductivity 7 (1994), S. 37-38 
    Details
    ISSN: 1572-9605
    Keywords: High-Tc superconductivity ; La1.9Bi0.1CuO4+δ ; excess oxygen ; crystal structure ; superconducting transition temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract We have investigated the relation between the crystal structure and superconductivity in La1.9Bi0.1CuO4+δ , in which the phase separation observed in La2CuO4+δ is suppressed. A phase diagram in theT−δ plane is given for La1.9Bi0.1CuO4+δ with excess oxygen. For very smallδ values, the crystal structure is orthorhombic, and an orthorhombic-tetragonal phase transition occurs markedly atδ ∼ 0.03 in the measured temperature range between 13 and 293 K. Superconductivity is observed in the range of 0.04〈δ〈0.11. This is clear evidence thathigh-T c superconductivity also appears in the tetragonal phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00730364
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  • 3
    Electronic Resource
    Electronic Resource
    Accumulation of wild-type p53 in astrocytomas is associated with increased p21 expression (1997)
    Springer
    Acta neuropathologica 94 (1997), S. 21-27 
    Details
    ISSN: 1432-0533
    Keywords: Key words p21 ; p53 ; Astrocytoma ; Single-strand ; conformation polymorphism ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Approximately one quarter of human astrocytomas show immunohistochemical positivity for p53 protein but lack p53 gene mutations, which could reflect either an accumulation of wild-type p53 protein or an inadequate sensitivity of mutation detection. Since wild-type p53 up-regulates p21 expression, increased p21 expression in those astrocytomas with p53 accumulation in the absence of mutations would argue that the protein was wild type in these tumors. We therefore compared p21 expression with p53 gene and protein status in 48 primary human astrocytomas. Single-strand conformation polymorphism analysis and direct sequencing of the p53 gene showed mutations in 11 tumors (22.9%), while immunohistochemistry revealed positive staining in 19 cases (39.6%). Those tumors with p53 immunopositivity in the absence of p53 mutation had significantly increased p21 expression when compared to either mutant p53 or p53-immunonegative cases. Neither p53 nor p21 status correlated with proliferation indices, as assessed by Ki-67 immunohistochemistry. These results support the hypotheses that functionally wild-type p53 accumulates in some astrocytomas, and that alternative cell cycle checkpoints (such as the p16 pathway) may be more important than p21 in regulating proliferation in astrocytomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050667
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  • 4
    Electronic Resource
    Electronic Resource
    Homozygous deletions of the CDKN2/p16 gene in dural hemangiopericytomas (1996)
    Springer
    Acta neuropathologica 91 (1996), S. 221-225 
    Details
    ISSN: 1432-0533
    Keywords: Key words CDKN2 ; Hemangiopericytoma ; Meningioma ; p16 ; p53
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract While most authors currently classify dural-based hemangiopericytoma (HPC) as a distinct entity rather than as a subtype of meningioma, the histogenesis of HPC has long been debated. We have recently shown that meningiomas contain frequent mutations of the neurofibromatosis 2 gene, while HPCs do not, suggesting that HPC is genetically distinct from meningioma. In the present study, we evaluated a series of 31 dural HPCs (including 3 pairs of primary and recurrent tumor) and 26 meningiomas for alterations in the cell-cycle regulatory genes CDKN2/p16 and p53. Homozygous deletions of the CDKN2/p16 gene were detected using a comparative multiplex polymerase chain reaction assay in 7 of 28 primary HPCs (25%), but in only one of 26 meningiomas (P = 0.03). Among the HPCs with recurrence, 1 pair of 3 had a homozygous CDKN2/p16 deletion. The 1 meningioma with a CDKN2/p16 deletion was a meningothelial meningioma, without atypical or malignant features. Single-strand conformational polymorphism analysis of all three exons of CDKN2/p16 and exons 5–8 of p53 revealed no mutations in either HPCs or meningiomas. These results illustrate that homozygous deletions of CDKN2/p16 occur in HPCs and suggest that alterations of the p16-mediated cell-cycle regulatory pathway may underlie the formation or progression of some HPCs. The data also provide further genetic evidence that HPC is not a subtype of meningioma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050419
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  • 5
    Electronic Resource
    Electronic Resource
    Substitution effects on the electronic anomaly and superconductivity in La2−xBaxCuO4 and La2−xSrxCuO4 with x ∼ 1/8 (1996)
    Springer
    Journal of low temperature physics 105 (1996), S. 317-322 
    Details
    ISSN: 1573-7357
    Keywords: 74.25.Fy ; 74.62.Dh ; 74.72.Dn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The effects of substitution of Y or Bi on the low-temperature structural phase transition, electronic anomaly and superconductivity have been studied in La2-y-xYyBaxCuOφ La2-y-xBiyBaxCuO4 and La1.9-y-xTb0.1BiySrxCuO4 with x = 1/8. Moreover, an electronic anomaly, which is analogous to those observed in La2−xBaxCuO4 and La1.6-xNd0.4SrxCuO4 with x ∼ 1/8, has been found below about 60 K in the thermoelectric power measurements for the Zn-substituted La2−xSrxCu1−yZnyO4 with x ∼ 0.115 and y = 0.01 – 0.02. These experimental results support the conclusions by Tranquada et al. that static order of the stripe correlations of holes and spins, owing to pinning by the low-temperature structure or impurities (Zn in this case), is the origin of the electronic anomaly, leading to the suppression of superconductivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00768405
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  • 6
    Electronic Resource
    Electronic Resource
    Intrathecal Chemotherapy with MX2 for Treating Glioma Dissemination in vivo (2000)
    Springer
    Journal of neuro-oncology 49 (2000), S. 41-47 
    Details
    ISSN: 1573-7373
    Keywords: MX2 ; dissemination ; malignant glioma ; intrathecal chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined whether the intrathecal MX2 chemotherapy for treating dissemination of malignant glioma would be a feasible therapy. In the toxicity study, physiological and histological neurotoxicity was not observed in the rats treated with less than 100 μg/kg of MX2 administered intracisternally. But physiological side effects were observed in the treatment group of more than 200 μg/kg and histological brain toxicity was in the treatment group of more than 1000 μg/kg. Dissemination models were induced in rats by intracisternal inoculation of C6 glioma cells. The median survival times of the rats treated with 100 μg/kg of intrathecal MX2 on day 1, 3, or 7 after tumor inoculation were prolonged by 52.4% (p=0.0006), 31.5% (p=0.0007), and 7.1% (p=0.0180), respectively, compared to that of untreated control animals. Intrathecal MX2 treatment also cured 33.6% of rats in the treatment group. These findings suggested that there was a possibility that intrathecal MX2 would be a safe and effective method for treating dissemination of malignant glioma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006436911670
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  • 7
    Electronic Resource
    Electronic Resource
    Relationship between expression of a major apurinic/apyrimidinic endonuclease (APEX nuclease) and susceptibility to genotoxic agents in human glioma cell lines (1995)
    Springer
    Journal of neuro-oncology 25 (1995), S. 183-192 
    Details
    ISSN: 1573-7373
    Keywords: APEX nuclease ; AP endonuclease ; DNA 3′ repair diesterase ; cellular sensitivity to genotoxic agents ; glioma cells (human)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The multifunctional DNA repair enzyme (APEX nuclease) having apurinic/apyrimidinic (AP) endonuclease, 3′-5′ exonuclease, DNA 3′ repair diesterase and DNA 3′-phosphatase activities is thought to be involved in repair of AP sites and single-strand breaks with 3′-blocked termini. To investigate the biological role of the enzyme, we studied the correlation between APEX AP endonuclease activity in several human glioma cell lines having various degree of its expression and cellular susceptibility to cytotoxic agents such as methyl methanesulfonate (MMS), 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hy-drochloride (ACNU), cis-diamminedichloroplatinum(II) (CDDP), etoposide (VP-16), hydrogen peroxide (H2O2), hyperthermia and X-ray. The cell lines having lower APEX expression showed higher sensitivity to MMS and H2O2 which are known to induce AP sites and single strand breaks on DNA, respectively. The cellular susceptibility to the other agents tested was not significantly correlated to the APEX expression. The present results are thought to support the notion that APEX nuclease plays an important role on repair of AP sites and single-strand DNA breaks with 3′-blocked termini in mammalian cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01053151
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  • 8
    Electronic Resource
    Electronic Resource
    Increased mRNA expression of a novel prostacyclin-stimulating factor in human colon cancer (1998)
    Springer
    Journal of gastroenterology 33 (1998), S. 213-217 
    Details
    ISSN: 1435-5922
    Keywords: Key words: prostacyclin ; prostacyclin-stimulating factor ; colon cancer ; carcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: We recently cloned a prostacyclin (PGl2)-stimulating factor (PSF), which stimulates PGl2 production by cultured vascular endothelial cells. Immunohistochemistry and Northern blot analysis demonstrated that PSF was highly expressed in colon cancer sites compared with normal colon mucosa obtained from the same patient, as well as in cultured adenocarcinoma cell lines compared with cultured normal colon mucosal cell lines. Increased levels of the PSF protein were detected in the culture media of these adenocarcinoma cells compared with levels in the culture media of normal mucosal cells. These results suggest that PSF is closely associated with carcinogenesis of colon mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050072
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