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Digitale Medien

Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells (2000)

Meng, Qinghui ; Goldberg, Itzhak D. ; Rosen, Eliot M. ; [weitere]

Springer

Breast cancer research and treatment 63 (2000), S. 147-152

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Details

ISSN: 1573-7217

Schlagwort(e): Indole-3-carbinol ; breast cancer ; invasion ; migration ; PTEN ; E-cadherin

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Indole-3-carbinol (I3C) is a promising phytochemical agent in chemoprevention of breast cancer. Our present study is the first description of I3C that significantly inhibits the cell adhesion, spreading and invasion associated with an up-regulation of PTEN (a tumor suppressor gene) and E-cadherin (a regulator of cell–cell adhesion) expression in T47-D human breast cancer cells. Therefore, I3C exhibits anti-cancer activities by suppressing breast tumor cell growth and metastatic spread. Metastatic breast cancer is a devastating problem, clinical application of I3C as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1006495824158

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