ISSN:
1573-7217
Keywords:
Indole-3-carbinol
;
breast cancer
;
invasion
;
migration
;
PTEN
;
E-cadherin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Indole-3-carbinol (I3C) is a promising phytochemical agent in chemoprevention of breast cancer. Our present study is the first description of I3C that significantly inhibits the cell adhesion, spreading and invasion associated with an up-regulation of PTEN (a tumor suppressor gene) and E-cadherin (a regulator of cell–cell adhesion) expression in T47-D human breast cancer cells. Therefore, I3C exhibits anti-cancer activities by suppressing breast tumor cell growth and metastatic spread. Metastatic breast cancer is a devastating problem, clinical application of I3C as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1006495824158
