ISSN:
1432-1912
Keywords:
Key words Taenia caeci (guinea-pig)
;
Nitric oxide
;
NG-nitro-l-arginine
;
P2 purinoceptors
;
PPADS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effect of the nitric oxide synthase inhibitor N G-nitro-l-arginine (l-NOARG; 100 µM) and the P2 purinoceptor antagonist pyridoxalphosphate-6-azophenyl-2’,4’-disulfonic acid (PPADS; 50 µM) was investigated on the non-adrenergic, non-cholinergic (NANC) relaxant response of the guinea-pig isolated taenia caeci to electrical field stimulation at 1 or 10 Hz, under isotonic recording conditions. Either drug alone caused an about 50% inhibition, while combining the two drugs nearly abolished the response at both frequencies. The inhibitory effect of l-NOARG (100 µM) was partly reversed by l-arginine (30 mM). PPADS, but not l-NOARG, inhibited the relaxant effect of exogenous ATP, but not that of the nitric oxide donor sodium nitroprusside. It is concluded that both nitric oxide and ATP are involved in the mediation of NANC relaxation in the taenia caeci, in an apparently additive manner.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00005283
Permalink
