Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Interdigestive pattern  (1)
  • Schlüsselwörter M. Crohn • MRT bei M. Crohn • Enteroklyse • MRT  (1)
  • 1
    ISSN: 1432-1440
    Keywords: Cholecystokinin ; Gastrointestinal hormones ; Human ; Interdigestive pattern ; Fed pattern ; Pancreatic secretion ; Neurotensin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of the present study was to assess the role of cholecystokinin and neurotensin in converting the cyclical interdigestive pattern of pancreatic secretion into the non-cyclical fed pattern. Six healthy male volunteers were studied on 4 separate days. During each experiment a mixed liquid meal or solutions of individual nutrients were perfused intraduodenally for 180 min at 2 ml/min. The mixed meal contained 4.3 g glucose, 2.0 g fractionated soya oil, and 1.7 g casein hydrolysate per 100 ml, which delivered a caloric load of 0.9 kcal/min into the duodenum. The isocaloric and isotonic solutions of individual nutrients contained 44.5 g glucose, 17.8 g fractionated soya oil, or 44.5 g hydrolysed serum bovine albumin per liter and delivered 0.36 kcal/min into the duodenum. Duodenal aspirates and blood samples were collected at regular intervals for determination of pancreatic enzyme outputs and plasma levels of cholecystokinin and neurotensin, respectively. The mixed meal converted the cyclical interdigestive secretory pattern into the noncyclical fed pattern whereas none of the three individual nutrients abolished the interdigestive pattern. Not only the mixed meal but also lipid and protein perfusion consistently stimulated cholecystokinin release. Integrated incremental cholecystokinin release amounted to 32.3±9.9 pg/ml × 180 min with the mixed meal, 23.2±6.5 with lipid perfusion (P〈 0.05 versus mixed meal) and 13.4±3.8 with protein perfusion (P〈0.05 versus mixed meal). The carbohydrate solution did not significantly release cholecystokinin. None of the duodenal perfusates raised neurotensin plasma levels. We conclude that (a) intraduodenal delivery of a mixed meal at 0.9 kcal/min converts the interdigestive pattern of pancreatic secretion, (b) cholecystokinin but not neurotensin is involved in converting this pattern in response to low-caloric meals, and (c) a threshold amount of CCK release must be exceeded to convert the secretory pattern.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-2102
    Keywords: Key words Crohns' disease • MRI in Crohns' disease • Enteroclysis • MRI ; Schlüsselwörter M. Crohn • MRT bei M. Crohn • Enteroklyse • MRT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Trotz der Verbesserung der MR-tomographischen Diagnostik wird die MRT weiterhin nur selten in der Routinediagnostik bei entzündlichen Dünndarmerkrankungen eingesetzt. Ziel der Untersuchung war die Korrelation der Befunde von Enteroklyse und MRT bei Patienten mit bekanntem M. Crohn nach Optimierung der Darmkontrastierung. Ferner wurde untersucht, ob die MRT Zusatzinformationen zur Enteroklyse liefern kann. 60 Patienten im Alter von 17–72 Jahren wurden untersucht. Zunächst wurde eine Enteroklyse in konventioneller Technik durchgeführt, wobei der Methylzellulose in einer Mischung von 1:10 positives orales MR-Kontrastmittel (Magnevist enteral) zugesetzt wurde. Nach Abschluß der Enteroklyse erfolgte die MRT unter Verwendung T1- und T2-gewichteter Sequenzen (Flash 2D vor und nach i. v. Gd-DTPA bzw. TSE) in Atemanhaltetechnik in koronarer und axialer Schnittführung. Die in der Enteroklyse nachweisbaren Schleimhautveränderungen und Stenosenlänge entsprachen einer nachweisbaren Darmwandverdickung bzw. Stenose in der MRT. Mit der MRT konnten bei 28 Patienten Zusatzbefunde wie Fisteln, Abszesse oder Hydronephrosen diagnostiziert werden, oder die Stenose war wegen der überlagerungsfreien Darstellung in der MRT besser beurteilbar als mittels Enteroklyse. Mit der MRT kann ein wesentlicher Beitrag in der Diagnostik von entzündlichen Darmerkrankungen geleistet werden. Grundvoraussetzung scheint vor allem ein hohes Füllungsvolumen des Dünndarmes zu sein, um eine homogene Kontrastierung und gute Distension zu erreichen.
    Notes: Summary In spite of the improved MR-diagnosis of the abdomen, MRI is not used as a routine method for the diagnosis of inflammatory small bowel disease. The aim of this study was – after optimazation of the bowel opacification – the correlation of the findings obtained with enteroclysis and MRI in patients with known Crohns' disease. 60 patients beween 17 and 72 years of age were investigated. First, an enteroclysis was performed in typical manner. The applicated methylcellulosis was blended with positive oral MR contrast media (Magnevist oral, Schering). After enteroclysis, MRI of the abdomen was performed using T1- and T2-weighted breathhold sequences (Flash 2D pre- and postcontrast and TSE) in axial and coronal planes. The lenght of the affected bowel and the stenosis seen with enteroclysis correlated well with the visible thickening of the small bowel wall and the stenosis seen in MRI. Using MRI, additional findings could be obtained in 28 patients, such as fistulas, abscesses or a hydronephrosis, or a better assessment of the stenosis was possible with MRI, because of the avoidance of overshadowing of the affected bowel loop with MRI. A brilliant MR-tomographic imaging of the small bowel is possible under the condition, that the small bowel contrast is optimal. The main prerequisite is a large filling volume of the small bowel to reach a homogeneous contrast and a good distension of the small bowel lumen.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...