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  • 1
    Electronic Resource
    Electronic Resource
    Interventionelle MR-gesteuerte laserinduzierte Thermotherapie bei onkologischen Fragestellungen Stand und Ausblick (1999)
    Springer
    Der Radiologe 39 (1999), S. 764-771 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter LITT ; Laserablation ; MR-Thermometrie ; Key words Laser ; MR thermometry ; LITT ; Liver cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary MR-guided LITT (laser-induced thermotherapy) is currently being evaluated for its effectiveness in clinical oncology. MR-guided LITT is defined as a minimally invasive technology based on the effects of the applied Nd-YAG laser on tumorous tissue. Due to specific characteristics of the laser-induced coagulative effect, online monitoring via MR thermometry is possible and extremely precise. In a period of 6 years 335 patients suffering from malignant soft tissue tumors were prospectively treated via MR-guided LITT. We evaluated the local tumor control rate, the rate of complications and the survival data from the clinical and MRI follow-up. Our results prove that MR-guided LITT results in a extremely low rate of side effects and an effective tumor control rate higher than 95%, depending on the size of the lesion. It is concluded that this therapeutic concept is of clinical value for patients with primary and secondary liver cancer, malignant lymph node involvement, abdominal recurrent tumors and tumors of the head and neck.
    Notes: Zusammenfassung Die interventionelle MR-gesteuerte laserinduzierte Thermotherapie (LITT) wird derzeit klinisch und im Rahmen prospektiver Studien bei unterschiedlichen onkologischen Fragestellungen eingesetzt und evaluiert. Per definitionem stellt die MR-gesteuerte laserinduzierte Thermotherapie ein minimalinvasives Therapieverfahren dar, das auf der Laserwirkung mit resultierendem koagulativen Effekt beruht. Der thermoablative Effekt wird dabei „online”überwacht und dokumentiert durch den Einsatz spezieller MR-Sequenzprotokolle. Innerhalb eines Zeitraums von 6 Jahren wurden dabei prospektiv 335 Patienten mit malignen Weichteiltumoren therapiert und die Tumorortskontrollrate, die Komplikationsrate sowie die Überlebensdaten evaluiert. Die gewonnenen Ergebnisse zeigen, daß die MR-gesteuerte LITT ein nebenwirkungsarmes Therapieverfahren darstellt, mit einer enorm hohen Präzision und einer Tumorortskontrollrate bei optimierter Technik von 〉95%. Als Indikationen werden vorgestellt die Thermotherapie von primären und sekundären Lebermalignomen, sekundärer Lymphknoteninvasionen, abdomineller Rezidivtumoren sowie Tumorfragestellungen in der Kopf-/Halsregion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050573
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  • 2
    Electronic Resource
    Electronic Resource
    Interventional MR: interstitial therapy (1999)
    Springer
    European radiology 9 (1999), S. 1479-1487 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Interventional MRI ; Interstitial therapy ; MR-guided laser-induced interstitial thermotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The rationale and results for interstitial therapies via interventional MRI in the treatment of tumors in various regions are presented. Different interstitial treatment techniques are presented based on varying technologies both for tumor ablation and treatment monitoring. Data are presented based on 335 patients, 29–84 years of age (mean age 59 years, 196 men and 139 women) with a total of 932 liver tumors, 16 head and neck tumors and 14 abdominal recurrent pelvic and lymphatic tumors. All lesions had been treated with MR-guided laser-induced interstitial thermotherapy (LITT) via 2516 laser applications and 1856 cannulations. Data in the literature are extremely varying depending on author experience, treatment technique, and the included patient material. In our patient material we were able to achieve a local tumor control of 96.7 % depending on the size of the tumorous lesion, the topographical relationship, and the applied laser parameters. The overall cumulative survival rate of patients with liver metastases was 45.74 months (median 40.97 months, 95 % confidence interval 31.42–50.52). The cumulative survival rate of the patient group with hepatic metastases of colorectal carcinoma was 42.71 months (median 39.33 months, 95 % confidence interval 33.26–45.37). In patients with head and neck tumors a relevant reduction in clinically relevant symptoms such as pain, swallowing disorders, or nervous compression was achieved in 11 of 15 patients treated with LITT. In 14 soft tissue tumors, such as pelvic tumor recurrence and lymph node metastases, a local tumor control was obtained in 68 % of lesions. Interstitial therapies under interventional MRI guidance, such as LITT, results in a high local tumor control with an improved survival rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050874
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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