Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-1084
    Keywords: Key words: Liver metastases ; Interventional treatment modalities ; Alcohol injection ; Drug instillation ; Radiofrequency ablation ; Cryotherapy ; Laser-induced interstitial thermotherapy ; Regional chemoembolisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The liver is the most common site of metastatic tumour deposits. Hepatic metastases are the major cause of morbidity and mortality in patients with gastrointestinal carcinomas and other malignant tumours. The rationale and results for interventional therapeutic techniques in the treatment of liver metastases are presented. For the treatment of patients with irresectable liver metastases, alternative local ablative therapeutic modalities have been developed. Technique and results of local interventional therapies are presented such as microwave-, radiofrequency (RF)- and ultrasound ablation, and laser-induced interstitial therapy (LITT), cryotherapy and local drug administration such as alcohol injection, endotumoral chemotherapy and regional chemoembolisation. In addition to cryotherapy, all ablative techniques can be performed percutaneously with low morbidity and mortality. Cryotherapy is an effective and precise technique for inducing tumour necrosis, but it is currently performed via laparotomy. Percutaneous local alcohol injection results in an inhomogeneous distribution in liver metastases with unreliable control rates. Local chemotherapeutic drug instillation and regional chemoembolisation produces relevant but non-reproducible lesions. Laser-induced interstitial thermotherapy (LITT) performed under MRI guidance results in precise and reproducible areas of induced necrosis with a local control of 94 %, and with an improved survival rate. Interventional therapeutic techniques of liver metastases do result in a remarkable local tumour control rate with improved survival results.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 9 (1999), S. 1479-1487 
    ISSN: 1432-1084
    Keywords: Key words: Interventional MRI ; Interstitial therapy ; MR-guided laser-induced interstitial thermotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The rationale and results for interstitial therapies via interventional MRI in the treatment of tumors in various regions are presented. Different interstitial treatment techniques are presented based on varying technologies both for tumor ablation and treatment monitoring. Data are presented based on 335 patients, 29–84 years of age (mean age 59 years, 196 men and 139 women) with a total of 932 liver tumors, 16 head and neck tumors and 14 abdominal recurrent pelvic and lymphatic tumors. All lesions had been treated with MR-guided laser-induced interstitial thermotherapy (LITT) via 2516 laser applications and 1856 cannulations. Data in the literature are extremely varying depending on author experience, treatment technique, and the included patient material. In our patient material we were able to achieve a local tumor control of 96.7 % depending on the size of the tumorous lesion, the topographical relationship, and the applied laser parameters. The overall cumulative survival rate of patients with liver metastases was 45.74 months (median 40.97 months, 95 % confidence interval 31.42–50.52). The cumulative survival rate of the patient group with hepatic metastases of colorectal carcinoma was 42.71 months (median 39.33 months, 95 % confidence interval 33.26–45.37). In patients with head and neck tumors a relevant reduction in clinically relevant symptoms such as pain, swallowing disorders, or nervous compression was achieved in 11 of 15 patients treated with LITT. In 14 soft tissue tumors, such as pelvic tumor recurrence and lymph node metastases, a local tumor control was obtained in 68 % of lesions. Interstitial therapies under interventional MRI guidance, such as LITT, results in a high local tumor control with an improved survival rate.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    facet.materialart.
    Unknown
    Menasha, Wis. : Periodicals Archive Online (PAO)
    The Accounting Review. 28:1 (1953:Jan.) 54 
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  · Background: One striking disadvantage of in vitro culturing of human retinal pigment epithelial (RPE) cells is the loss of epithelial differentiation and specific cell function during culture. This may be one of the main reasons for the failure of RPE cell transplantation. The aim of this study was to evaluate cell culture conditions ensuring the maintenance of differentiation and function of RPE cells after subcultivation and storage in liquid nitrogen. · Methods: Enzymatically isolated cells were seeded onto coated culture dishes, cultured with a specially formulated improved growth medium until confluence and then cryopreserved in liquid nitrogen for 16–66 months. HLA class I and II typing was performed before cryopreservation and after thawing. Expression of Ca2+ channels in primary, first-passage and cryopreserved RPE cells was studied using the patch-clamp technique. · Results: After cryopreservation no loss of any HLA antigen was detectable in 12 of 14 cell strains studied. Patch-clamp experiments demonstrated that high-threshold L-type Ca2+ channels, which are typical for freshly isolated cells, could be detected in first-passage and cryopreserved RPE cells only when improved culture conditions were employed, not in conventionally cultured cells. The characteristics of these channels showed little change in subcultured cells compared to primary cultures. · Conclusion: This is the first study showing the maintenance of adult human RPE-specific cell differentiation and characteristics in vitro after primary culture and after cryopreservation using improved cell culture methods. The optimization and quality control of cell culture is an important prerequisite for successful cell transplantation.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 238 (2000), S. 181-185 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  · Background:Perfluorocarbon liquids are useful intraoperative tools in complicated vitreoretinal surgery. They are usually removed at the end of the procedure, but small amounts may remain in the eye. Recently, contradictory results have been reported on the damage in association with residual perfluorocarbon liquids in the eye. This study examined the effects of perfluorodecalin on human retinal pigment epithelium and corneal endothelium in vitro. · Methods:Vitality and proliferative capacity of cell cultures were measured after incubation with perfluorodecalin. Vitality of cell cultures were measured using the Life-Dead assay. Cell proliferation was determined by measuring incorporation of 5-bromo-2’-deoxyuridine into cellular DNA. Furthermore, endothelium of organ-cultured human corneas was examined after incubation with perfluorodecalin by photodocumentation. · Results:Both cell types showed less extinctions in the Life-Dead assay after incubation with perfluorodecalin. After removing perfluorodecalin from the cultures, cells showed the same capacity of proliferation as the control cells. Compared to control corneas, perfluorodecalin induced a decrease in endothelial cell density. In four corneas, endothelial cell necrosis was observed. · Conclusion:Decreasing extinctions in the Life-Dead assay after incubation with perfluorodecalin can be interpreted as showing a decreasing amount of vital cells. Because cell proliferation showed no significant changes the results suggest that perfluorodecalin may not be directly toxic to cells in vitro. It may exert an indirect or mechanical effect on cell function by impeding the normal metabolic exchange between endothelium and medium. Based on these results perfluorodecalin should be completely removed after operation.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1433-0393
    Keywords: Key words Livermetastases • Breast carcinoma • ; Laser induced thermotherapy • Minimally invasive therapy ; Schlüsselwörter Lebermetastasen • Mammakarzinom • Laserinduzierte Thermotherapie • Minimal-invasive Therapien
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Rahmen der hämatogenen Metastasierung des Mammakarzinoms stellt die Leber ein häufig betroffenes Organ dar. Im Falle eines isolierten Befalls der Leber werden bei fehlendem Ansprechen auf Chemo- und Hormontherapie im Einzelfall lokal sanierende Maßnahmen wie die chirurgische Resektion oder auch minimal-invasive Verfahren wie Tumorablationen diskutiert. Im Rahmen eines klinischen Programms wurden daher prospektiv 51 Patienten mit sekundär metastatischem Befall der Leber bei Mammakarzinom mittels MR-gesteuerter laserinduzierter Thermotherapie in Lokalanästhesie therapiert. Die mittels MR-gesteuerter LITT erzielte lokale Tumorkontrolle in der Leber lag in der 3-Monats-Kontrolle bei 98,2 %, in der 6-Monats-Kontrolle bei 97,1 %. Die mittlere Überlebensrate, berechnet ab Diagnosestellung der gelaserten Metastase betrug 50,29 (95-%-Konfidenzintervall (KI) 41,99–58,59) Monate. Berechnet ab dem Tag der Laserbehandlung betrug die mittlere Überlebensrate 36,31 (95-%-KI 30,40 – 42,22) Monate. Die LITT erlaubt heute eine hohe lokale Tumorkontrollrate; mögliche Indikationen liegen bei Patienten mit primär hepatischer Metastasierung, bei denen trotz Chemo- und Hormontherapie residuelle Lebermetastasen nachgewiesen werden oder diese progredient sind.
    Notes: Summary The liver is one of the most involved organs in the case of hematogenous metastases of breast carcinoma. In strictly intrahepatic involvement of breast cancer local ablative methods like surgical resection and minimal-invasive treatment modalities are discussed when systemic chemo- or hormone therapies are ineffective. In the clinical programme 51 patients with secondary metastastic involvement of the liver due to breast carcinoma were prospectively treated via MR-guided laser-induced thermotherapy in an outpatient setting. Patients were included with a maximum of five lesions up to a maximum diameter of 5 cm. Patients with additional extrahepatic involvement are excluded. MR-guided LITT allowed local tumor control in the liver at three months of 89.2 % and at six months of 79.1 %. The cumulative median survival rate was 50,29 months (confidence interval 95 %, 41.99–42.22 months). MR-guided LITT allows high local tumor control. Possible indications for the treatment with LITT are patients with strictly intrahepatic metastases who are not demonstrating a complete response after chemo- or hormone therapy.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 164 (1974), S. 45-48 
    ISSN: 1433-8580
    Keywords: Furosemide ; Mefruside ; Inulin clearance ; Antiadrenergic ; Furosemid ; Mefrusid ; Inulin-Clearance ; Antiadrenerg
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Furosemid erhöhte an Ratten vorübergehend signifikant die Inulin-Clearance. Nach Mefrusid kam es zu einer geringen, jedoch nicht signifikanten Erhöhung. Hydrochlorothiazid und Chlorthalidon senkten die Inulin-Clearance signifikant. Am isolierten Vas deferens der Ratte zeigte sich, daß Furosemid und Mefrusid nichtkompetitive antiadrenerge Eigenschaften haben; die vielfach beschriebene Beeinflussung der renalen Hämodynamik durch Furosemid läßt sich damit gut erklären. Hydrochlorothiazid und Chlorthalidon zeigten am isolierten Organ keine Wirkung.
    Notes: Summary In experiments on rats furosemide temporary produced a significant increase of the inulin clearance. By using mefruside only slight increase was noticed. Hydrochlorothiazide and chlorthalidon lowered the inulin clearance substantially. On the isolated vas deferens of the rat it was shown, that furosemide and mefruside have non-competitive antiadrenergic qualities. The often described effects on renal hemodynamics due to furosemide can readiliy be explained. Hydrochlorothiazide and chlorthalidon showed no effects on the isolated organs.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Der Ophthalmologe 97 (2000), S. 257-263 
    ISSN: 1433-0423
    Keywords: Schlüsselwörter Kataraktextraktion ; Postoperative Endophthalmitis ; Erregerspektrum ; Vitrektomie ; Key words Cataract extraction ; Postoperative endophthalmitis ; Microbiological spectrum ; Vitrectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background: Infectious exogenous endophthalmitis is a serious complication after cataract surgery. Despite modern pharmacological and surgical methods, its treatment is still difficult. Patients and methods: In a retrospective study the records of all patients treated for endophthalmitis following cataract extraction at the Department of Ophthalmology of the University Hospital in Hamburg between January 1989 and December 1997 were assessed. Results: Of 36 patients treated for endophthalmitis, 29 (80.6%) had been referred. In 14 (38.9%) of these 29 patients endophthalmitis had occurred after outpatient cataract surgery. Seven patients (19.4%) had been treated as inpatients at the University Eye Hospital Eppendorf. Vitrectomy was performed in 80.6% of the cases. An infectious agent was isolated from 50% of diagnostic probes. The most common organism isolated were coagulase-negative staphylococci (4 cases). Predisposing factors for the development of endophthalmitis were diabetes (27.8%), intraoperative loss of vitreous (19.4%), application of systemic steroids (13.9%) and wound dehiscence (11.1%). Of 27 patients (75%) followed up, 16 (59.3%) had a final visual acuity of 20/400 or better (mean 20/40). An enucleation had to be performed in 4 patients (13.8%). Conclusion: In this study, approximately 60% of patients with endophthalmitis following cataract extraction had their globes preserved and a good visual outcome after appropriate surgical interventions.
    Notes: Zusammenfassung Hintergrund: Die infektiös bedingte exogene Endophthalmitis stellt eine ernste Komplikation nach Kataraktoperation dar. Sie ist trotz moderner medikamentöser und chirurgischer Behandlungsmethoden oftmals schwer therapierbar. Patienten und Methoden: In einer retrospektiven Studie wurden alle Patienten (n=36) untersucht, die zwischen Januar 1989 und Dezember 1997 an der Universitäts-Augenklinik Hamburg-Eppendorf (UKE) aufgrund einer Endophthalmitis nach Kataraktextraktion behandelt worden waren. Ergebnisse: Von 36 Patienten wurden der Klinik 29 (80,6%) von außerhalb zugewiesen. 14 Patienten (38,9%) hatten eine Endophthalmitis nach ambulanter Kataraktextraktion entwickelt. 7 Patienten (19,4%) waren stationär in der Augenklinik UKE operiert worden. Bei 29 der Patienten (80,6%) wurde eine Vitrektomie vorgenommen. Ein Erreger konnte aus 50% der Vorderkammer- bzw. Glaskörperproben isoliert werden, am häufigsten Koagulase-negative Staphylokokken (n=4). Zu den prädisponierenden Faktoren der Endophthalmitis zählten Diabetes mellitus (27,8%), perioperativer Glaskörperverlust (19,4%), systemische Kortikosteroidtherapie (13,9%) und Wunddehiszenz (11,1%). Von 27 nachuntersuchten Patienten (75%) erreichten 16 (59,3%) einen Visus von 0,05 oder besser (durchschnittlicher Visus 0,5). Bei 4 Patienten (13,8%) mußte eine Enukleation vorgenommen werden. Schlussfolgerung: In der vorliegenden Studie konnte bei etwa 60% der Patienten mit einer postoperativen Endophthalmitis das Auge erhalten und eine optische Rehabilitation durch chirurgische Intervention erzielt werden.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1433-0423
    Keywords: SchlüsselwörterÜberdruckbeatmungsgerät CPAP ; Nasale Ventilation ; Keratoplastik ; Epithelialisierung ; Wundheilung ; Schlafapnoe ; Key words CPAP hyperbaric respirator ; Nasal ventilation ; Keratoplasty ; Epithelialization ; Wound healing ; Sleep apnea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Nasal hyperbaric respiration devices used at night to counteract sleep apnea may represent a concealed cause of delayed superficial wound healing following perforating keratoplasty. We report the cases of two patients whose respirators produced a continuous flow of pressurized air (nCPAP) onto the operated eye, leading to conjunctival hyperemia, recurrent corneal erosion, infiltration of the puncture track and the cornea, and superficial punctate keratopathy. Microbiological investigation revealed no clearly identifiable pathogens. Healing improved consistently only after the pressurized air system had been modified so that no air escaped from the nostrils and the patients had been instructed in disinfection of the moisturizing system.
    Notes: Zusammenfassung Nächtlich verwendete nasale Überdruckbeatmungsgeräte gegen Schlafapnoe können eine versteckte Ursache für oberflächliche Wundheilungsstörungen nach perforierender Keratoplastik darstellen. Wir berichten über zwei Patienten, deren Beatmungsgeräte einen kontinuierlichen Druckluftstrom (nCPAP) an die operierten Augen brachten und zu konjunktivaler Hyperämie, rezidivierender Erosio corneae, Stichkanal- und Hornhautinfiltraten und Keratopathia superficialis punctata führten. Die mikrobiologischen Befunde zeigten keine eindeutig pathogenen Erreger, sondern erst die Änderung des Druckluftsystems mit jeweils nasaler Dichtigkeit und hygienische Patienteninstruktion zur Desinfektion des Befeuchtungssystems erbrachten einen kontinuierlichen guten Heilverlauf.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1432-2102
    Keywords: Schlüsselwörter LITT ; Laserablation ; MR-Thermometrie ; Key words Laser ; MR thermometry ; LITT ; Liver cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary MR-guided LITT (laser-induced thermotherapy) is currently being evaluated for its effectiveness in clinical oncology. MR-guided LITT is defined as a minimally invasive technology based on the effects of the applied Nd-YAG laser on tumorous tissue. Due to specific characteristics of the laser-induced coagulative effect, online monitoring via MR thermometry is possible and extremely precise. In a period of 6 years 335 patients suffering from malignant soft tissue tumors were prospectively treated via MR-guided LITT. We evaluated the local tumor control rate, the rate of complications and the survival data from the clinical and MRI follow-up. Our results prove that MR-guided LITT results in a extremely low rate of side effects and an effective tumor control rate higher than 95%, depending on the size of the lesion. It is concluded that this therapeutic concept is of clinical value for patients with primary and secondary liver cancer, malignant lymph node involvement, abdominal recurrent tumors and tumors of the head and neck.
    Notes: Zusammenfassung Die interventionelle MR-gesteuerte laserinduzierte Thermotherapie (LITT) wird derzeit klinisch und im Rahmen prospektiver Studien bei unterschiedlichen onkologischen Fragestellungen eingesetzt und evaluiert. Per definitionem stellt die MR-gesteuerte laserinduzierte Thermotherapie ein minimalinvasives Therapieverfahren dar, das auf der Laserwirkung mit resultierendem koagulativen Effekt beruht. Der thermoablative Effekt wird dabei „online”überwacht und dokumentiert durch den Einsatz spezieller MR-Sequenzprotokolle. Innerhalb eines Zeitraums von 6 Jahren wurden dabei prospektiv 335 Patienten mit malignen Weichteiltumoren therapiert und die Tumorortskontrollrate, die Komplikationsrate sowie die Überlebensdaten evaluiert. Die gewonnenen Ergebnisse zeigen, daß die MR-gesteuerte LITT ein nebenwirkungsarmes Therapieverfahren darstellt, mit einer enorm hohen Präzision und einer Tumorortskontrollrate bei optimierter Technik von 〉95%. Als Indikationen werden vorgestellt die Thermotherapie von primären und sekundären Lebermalignomen, sekundärer Lymphknoteninvasionen, abdomineller Rezidivtumoren sowie Tumorfragestellungen in der Kopf-/Halsregion.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...