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  • 1
    ISSN: 1432-1440
    Keywords: Insulin infusion pump ; Implantation ; CSII ; Intravenous, intraperitoneal insulin infusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five type I diabetic patients were followed prospectively during treatment with continuous subcutaneous insulin infusion by externally worn pumps and during the first 12 months after implantation of a remote-controlled insulin infusion device (ID1, Siemens AG). Stabilized insulin (Hoe 21 GH, Hoechst AG) was infused intravenously in two and intraperitoneally in three patients. Total observation time was 47.2 patient-months after implantation. Two devices had to be explanted prematurely, one because of a technical failure after 101 days, one due to a skin necrosis over the implant after 236 days. HbA1, frequency of hypoglycemia, total insulin dose, and basal rate infusion did not change after implantation. There was a reduction in the insulin antibodies 6 months after start of intravenous or intraperitoneal insulin delivery. Fasting plasma free insulin levels could be normalized only by intraperitoneal insulin infusion. Although a technical and a surgical problem was observed, our data show the successful implantation and clinical use of programmable dosing devices and stabilized insulin.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 219 (1974), S. 105-115 
    ISSN: 1433-8491
    Keywords: Clinical Neuropathology ; Postmortem Tissue Preservation ; Electron Microscopy of Human Brain Tissue ; Klinische Neuropathologie ; Postmortale Gewebserhaltung ; Elektronenmikroskopische Untersuchung menschlichen Hirngewebes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit der transorbitalen Nadelautopsie wird eine Technik beschrieben, welche die Entnahme von menschlichem Hirngewebe etwa innerhalb einer Viertelstunde post mortem ermöglicht. Die Stanzzylinder aus dem Orbitalbereich des Frontallappens weisen auf der submikroskopischen Ebene gewöhnlich eine befriedigende bis ausgezeichnete Strukturerhaltung auf. Die Brauchbarkeit der Methode wird auch durch Beispiele interessanter akzidenteller Beobachtungen bei fünf Fällen erläutert, die klinisch weder neurologische noch psychiatrische Störungen gezeigt hatten. Mit Hilfe der frühzeitigen transorbitalen Nadelautopsie lassen sich vor allem elektronenmikroskopische Untersuchungen bei bisher ungeklärten zentralnervösen Krankheitsprozessen durchführen. Außerdem bietet diese Entnahmetechnik auch die Möglichkeit, umfassendere Kenntnisse über die Normvarianten der feineren Strukturverhältnisse im Gehirn von Menschen verschiedener Altersstufen zu gewinnen.
    Notes: Summary We describe a method of transorbital needle autopsy for sampling cerebral tissue about 15 min after death. The specimens of orbital gray and white matter examined under the electron microscope exhibited a tissue preservation ranging from satisfactory to excellent. The validity of the method received further confirmation by some interesting incidental findings observed in five cases known to have been free of neurologic and psychiatric disease. Attention is called to the usefulness of this approach for the ultrastructural study of the brain in various pathologic situations of neurologic and/or psychiatric interest. Furthermore, the importance of this method as a means to obtain an ultrastructural baseline of human central nervous tissue in different age groups is briefly mentioned.
    Type of Medium: Electronic Resource
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