Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    The intercellular gaps of the neuropil as possible pathways for virus spread in viral encephalomyelitides (1971)
    Springer
    Acta neuropathologica 17 (1971), S. 37-43 
    Details
    ISSN: 1432-0533
    Keywords: Encephalomyelitis, Viral, Experimental ; Group B Arboviruses ; Central Nervous System, Viral Spread ; Neuropil, Extracellular Spaces ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei erwachsenen weißen Mäusen wurde durch intracerebrale Infektion mit dem Zimmern-Virus, ein dem TBE-Komplex angehörendes Arbovirus der Gruppe B, eine Encephalomyelitis erzeugt. Bei ultrastrukturellen Untersuchungen dieses Prozesses konnten einige interessante Beobachtungen gemacht werden. Zimmern-Viruspartikel, welche einen Durchmesser von etwa 400–450 Å haben, wurden nicht nur innerhalb zahlreicher Nervenzellen, sondern wiederholt auch in den Intercellularfugen des Neuropils angetroffen. Aufgrund dieses Befundes ist es sehr wahrscheinlich, daß die extracellulären Räume im ZNS intra vitam wesentlich weiter sind als man sie nach Anwendung der üblichen elektronenmikroskopischen Präparationsverfahren zu Gesicht bekommt. Es liegt somit auch die Annahme nahe, daß die Intercellularspalten als Wege für die Ausbreitung zumindest von kleineren Viren (z. B. Picornaviren und Arboviren der Gruppe B) im eigentlichen Hirn- und Rückenmarksgewebe dienen können.
    Notes: Summary An encephalomyelitis was produced in adult albino mice by intracerebral infection with the Zimmern virus, which is a group B arbovirus belonging to the TBE complex. Ultrastructural studies of this process showed some interesting results. Zimmern virus particles, which measure about 400 to 450 Å in diameter, could be observed, not only inside numerous neurons, but also repeatedly within the intercellular gaps of the neuropil. This finding makes it very likely that the extracellular spaces of the CNS are considerably wider in the intravital state than they appear to be after employing the conventional electron microscopic preparatory techniques. One may also conclude, therefore, that the intercellular clefts can serve as pathways for the spread of at least smaller virions (e. g., picorna viruses and group B arboviruses) throughout the parenchyma of the brain and spinal cord.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684739
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Bildung von markscheidenähnlichen Spiralstrukturen durch lamelläre Astrocytenausläufer innerhalb subpialer und perivasculärer Gliosen des Säugetiergehirns (1969)
    Springer
    Acta neuropathologica 12 (1969), S. 98-102 
    Details
    ISSN: 1432-0533
    Keywords: Marginal Siderosis ; Electron Microscopy ; Myelin-Sheath-Like Structures ; Plaques Fibromyéliniques ; Gliosis, Perivascular, Subpial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Kaninchen mit einer experimentell erzeugten Randzonensiderose des Zentralnervensystems konnten elektronenmikroskopisch in der Großhirnrinde eigentümliche Spiralstrukturen beobachtet werden. Diese Spiralen fanden sich vornehmlich im Bereich von subpialen und perivasculären Gliosen vor. Sie bestanden aus äußerst dünnen lamellären Astrocytenausläufern, welche um andere astrocytäre Zellfortsätze oder um Dendriten aufgewickelt waren. Die spiralisierten Astrocytenausläufer wiesen in ihrem Inneren feine Filamente mit einer ziemlich regelmäßigen Anordnung auf. In radiärer Richtung ließen die astrocytären Lamellenspiralen eine periodische Schichtung erkennen, welche etwas an die von echten Markscheiden erinnerte. Es wird in Betracht gezogen, daß sie das submikroskopische Äquivalent der sog. Plaques fibromyéliniques darstellen.
    Notes: Summary Peculiar spiral structures could be observed by electron microscopy in the cerebral cortex of rabbits with an experimentally produced marginal siderosis of the central nervous system. These spirals were found predominantly within areas of subpial and perivascular gliosis. They consisted of extremely thin lamellar astrocyte extensions winding around other astroglial processes or dendrites. The spirally coiled astrocyte extensions exhibited within their interior fine filaments having a rather regular arrangement. In the radial direction, the astrocytic lamellae spirals showed a periodic stratification somewhat resembling that of true myelin-sheaths. They were considered to represent the submicroscopic equivalent of the socalled plaques fibromyéliniques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685315
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    On so-called “virus-like” intranuclear filaments in brain autopsy material: A reappraisal on hand of two fatal cases of tick-borne encephalitis (1974)
    Springer
    Acta neuropathologica 28 (1974), S. 69-73 
    Details
    ISSN: 1432-0533
    Keywords: Virus-like Structures ; Paramyxovirus-type Nucleocapsids ; Post Mortem Chromatin Changes ; Tick-borne Encephalitis ; Multiple Sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopic examination of specimens of central nervous system necropsy from two cases of tick-borne encephalitis revealed a number of nuclei containing collections of filaments strikingly similar to those recently described as virus-like structures in multiple sclerosis and other neurological conditions. The occurrence of such intranuclear filaments in a group B togavirus infection suggests that either they represent a postmortem chromatin change, as we are inclined to think; or they are due to a harmless infection with one or more widely distributed viral agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687519
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Experimental vaccinia virus meningoencephalitis in adult albino mice: Virological, light microscopic and ultrastructural studies (1977)
    Springer
    Acta neuropathologica 40 (1977), S. 193-205 
    Details
    ISSN: 1432-0533
    Keywords: Poxvirus group ; Vaccinia virus, neurovirulent ; Neurovaccinia strains ; Meningoencephalitis, experimental ; Virus morphogenesis ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adult NMRI mice were inoculated intracerebrally with 1.5–5×102 pfu of the “neurovirulent” strain Ma1 of vaccinia virus. The animals usually became diseased on day 3 and died on day 5 or 6 p.i. Infectivity assay studies on the mouse brains yielded a steeply rising viral titer comparable with that exhibited by several other so-called neurovaccinia strains after intracerebral inoculation. Histological studies revealed a patchy leptomeningitis most apparent over the basal brain surface. Mononuclear elements of varied size were the most common infiltrate cells in the meningitic lesions. These often showed a pronounced hemorrhagic and necrotizing character. In some places, the cellular infiltrates within the subarachnoid space extended along the perforating vessels into the superficial cerebral cortex. By electron microscopy, all essential stages of virus morphogenesis including the discharge of mature virions could be seen in numerous mononuclear phagocytes and adventitial cells. In contrast to this, no unequivocal neuroectodermal cell showed morphologic evidence of productive viral infection. Likewise, no endothelia or vascular myocytes were encountered which contained newly formed virus particles. However, alterations of the walls of blood vessels and signs of disturbed vascular permeability were a frequent finding in the meningeal foci of inflammation as well as in and around the track left by the inoculating needle. Another ultrastructural feature of the meningitic lesions was the widespread occurrence of degenerating or disintegrating infiltrate cells both infected and uninfected ones. The virologic and morphologic findings observed in this model of experimental vaccinia virus meningo-encephalitis are discussed with regard to data previously published by other authors. The propensity of strain Ma1 of vaccinia virus (and most probably of other so-called neurovaccinia strains) for replication in mesenchymal cells in particularly emphasized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691954
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructural cytochemical demonstration of peroxidase-positive monocyte granules: An additional method for studying the origin of mononuclear cells in encephalitic lesions (1978)
    Springer
    Acta neuropathologica 43 (1978), S. 55-61 
    Details
    ISSN: 1432-0533
    Keywords: Reactive mononuclear cells, monocyte-derived ; Brain macrophages ; Rod cells ; Glial nodules ; Virus encephalitis, experimental ; Peroxidase cytochemistry, ultrastructural
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Unlike lymphocytes, blood monocytes possess in their cytoplasm peroxidase-positive (azurophil) granules (ppg) which largely correspond to the homonymous organelles of neutrophil granulocytes. We tested whether ppg, demonstrated cytochemically at the submicroscopic level, could serve as markers of monocyte-derived reactive mononuclear cells in encephalitic lesions. Samples of cerebrocortical tissue from adult albino mice with experimental yellow fever virus encephalitis were incubated in a medium containing diaminobenzidine and H2O2 for localization of peroxidatic activity. Mononuclear cells exhibiting ppg were found (1) in the lumen of brain venules, (2) in different stages of migration through the walls of such vessels, (3) in perivascular areas, (4) in the glioneuropil, either loosely scattered or forming small clusters, (5) in a satellite position to neurons, and (6) in leptomeningitic infiltrates. Several mononuclear elements harboring ppg had assumed an elongated, rod cell-like out-line. Amongst the peroxidase-negative mononuclears were fully developed brain macrophages and elements showing morphologic features characteristic of activated lymphocytes. Most mononuclear cells without ppg resembled the peroxidase-reactive ones. The results of this study provide direct evidence in favor of a monocytic origin of, at least, numerous reactive mononuclear elements in encephalitic lesions. The approach followed in the present study is not suitable for quantitative investigations of the histogenesis of mononuclear cells responding to brain injuries, since emigrated blood monocytes rapidly lose their ppg, particularly, when they display enhanced phagocytic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684998
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Carcinose der Hirnkammern infolge Geschwulstzellaussaat auf dem inneren Liquorweg (1966)
    Springer
    Acta neuropathologica 6 (1966), S. 14-24 
    Details
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Two cases of bronchogenic carcinoma with multiple metastases on the walls of the entire cerebral ventricular system are reported. In both cases, these ventricular metastases were the results of dissemination through the inner cerebrospinal fluid from a larger hematogeneous metastatic tumour which was located within the white matter of the parietal lobe and which had penetrated into the lateral ventricle. From a pathogenetic point of view, it is interesting that the shedding of cancer cells into the ventricular cerebrospinal fluid does not always lead to the formation of such ependymal daughter-tumours. Whether or not these “liquorogeneous” metastases develop in the ventricular walls is probably much more dependent on the biological properties of the tumour cells (e.g., degree of intrinsic malignancy, content of destructive enzymes, etc.) than on the possible preexistence of defects in the ependyma.
    Notes: Zusammenfassung Es wird über zwei Fälle von Bronchialcarcinom berichtet, bei denen es auf dem Wege des inneren Liquors zu einer Abseidlung disseminierter Tochtergeschwülste an den Wandungen sämtlicher Hirnkammern gekommen war. Als Ausgangsort der Carcinomzellaussaat in die inneren Liquorräume fand sich bei beiden Fällen eine größere, hämatogen entstandene Marklagermetastase vor, welche in den Seitenventrikel eingebrochen war. Die bei der Erörterung der Befunde angestellten pathogenetischen Überlegungen führten zu dem Schluß, daß für das Angehen “liquorogener” Ventrikelwandmetastasen die biologischen Eigenschaften der Blastomzellen wahrscheinlich ausschlaggebender sind als bereits vor der Dissemination der letzteren vorhandene Defekte im Ependym.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691078
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Electron microscopic studies of rabbit central and peripheral nervous system in experimental Borna disease (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 305-318 
    Details
    ISSN: 1432-0533
    Keywords: Encephalitis, Viral, Experimental ; Electron Microscopy ; Nervous System, Central and Peripheral ; Crystalline Aggregates ; Filamentous Collections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The CNS and posterior root ganglia of rabbits experimentally infected with Borna virus were studied by electron microscopy. Intracytoplasmic crystalline arrays were common in the non-neuronal cell elements of the central and peripheral nervous tissues of all infected animals. Peculiar filamentous collections were seen occasionally in the central and peripheral neurons of one third of the inoculated rabbits. Control animals showed no such changes. In the affected tissues the nuclear density was increased. There were numerous cells grouped around the vessels or scattered singly or in clusters in the parenchyma. Amongst them plasma cells could be recognized as well as mononuclear cells of hematogenous origin, microglia cells in various reactive stages and macrophages derived from either of the latter cell types. The nonspecific character of the crystalline aggregates is emphasized. The questionable viral nature of the filamentous bundles is considered briefly; other explanations as to their nature are also mentioned. Finally, attention is drawn to the heterogeneous composition of the glial nodules and to the ultrastructural variability of the various cell types found in the inflamed tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00809242
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Intraneuritic corpora amylacea (1974)
    Springer
    Virchows Archiv 364 (1974), S. 297-301 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Within the framework of an Early Postmortem Brain Sampling Program we had the opportunity to make some light and electron microscopic observations on the orbital cortex of two elderly subjects known to have been free of neurologic and psychiatric disease. Filamentous deposits with the ultrastructural appearance of corpora amylacea were seen inside astrocytic and, more rarely, inside neuronal processes. The findings and their interpretation are discussed in the light of current views on cerebral corpora amylacea and Lafora bodies. It is concluded that today's views on this matter do not account satisfactorily for the present observation or for observations we have quoted from the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432727
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Discrepancies between the sites of replication and cytocidal action of encephalitogenic viruses (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 97-98 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die Ergebnisse elektronenmikroskopischer Untersuchungen spechen dafür, dass encephalitogene Viren nicht immer jene Zellarten am stärksten schädigen, durch welche sie bevorzugt repliziert werden. Bei der experimentellen Poliomyelitis des Java-Affen fanden sich Polioviruskristalle häufig in weitgehend intakt erscheinenden mesenchymalen Zellelementen, niemals dagegen in den meist nekrobiotisch alterierten spinalen Motoneuronen vor.Bei einigen experimentellen Arbovirus-Encephalomyelitiden der Albinomaus wiederum konnten Viruspartikel ausschliesslich in Nervenzellen beobachtet werden, welche aber gewöhnlich nur geringfügige Strukturveränderungen aufwiesen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01928287
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    High structural stability of vascular and glial basement membranes in areas of total brain tissue necrosis (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 976-977 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung An der Grosshirnrinde von Goldhamstern wurde durch lokale Kälteeinwirkung eine umschriebene Erweichung hervorgerufen. Im Zentrum derselben wiesen nicht nur die neuronalen und gliösen Gewebskomponenten, sondern häufig auch die Blutgefässe schwerste nekrotische Strukturveränderungen auf. Bemerkenswerterweise blieben selbst nach dem völligen Untergang der Gefässwandzellen und der perivaskulären Astrozytenfu\stÜcke die vasalen und gliösen Basalmembranen eine gewisse Zeit erhalten. Bei grösseren kortikalen Blutgefässen konnte sogar wiederholt beobachtet werden, dass die von astrozytären Zytoplasmafortsätzen bereits völlig entblössten gliösen Basalmembranen noch imstande waren, die Ausbreitung massiver perivaskulärer Erythrozytenansammlungen in das umgebende nekrotische Neuropil zu verhindern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01898099
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...