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  • Japanese  (1)
  • Key words Insulin gene, polymorphism, Type 1 (insulin-dependent) diabetes mellitus, Japanese, susceptibility.  (1)
  • Metacarpal bone  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Association of polymorphism in the interferon γ gene with IDDM (1994)
    Springer
    Diabetologia 37 (1994), S. 1159-1162 
    Details
    ISSN: 1432-0428
    Keywords: Interferon gamma ; gene ; polymorphism ; association ; insulin dependent diabetes mellitus ; susceptibility ; Japanese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cytokines may play importmant roles in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). We analysed a dinucleotide repeat polymorphism within the first intron of the interferon γ (IFN-γ) gene in Japanese diabetic patients (175 IDDM and 145 non-insulin-dependent diabetes mellitus) and 267 control subjects. A significant difference was observed in the global allele distribution of the polymorphism between the IDDM and control groups (p=0.039). The difference from the control group was more evident in the patients whose insulin therapy started within 1 year from onset (p=0.006) or in the young-onset (〈10 years) patients (p=0.0006). The alleles “3” and “6” were increased in the IDDM patients, and a significant increase in the frequency of the “3/6” genotype was observed in the IDDM patient group (9.1%, RR 2.9, p=0.010), in the patients with initial insulin therapy less than 1 year from onset (10.6%, RR 3.4, p=0.004), or in the young-onset patients (16.7%, RR 5.7, p=0.0003) in comparison to the control subjects (3.4%). There was a tendency towards frequent occurrence of clinical characteristics which reflect young or abrupt onset of diabetes or both, and depletion of insulin secretion capacity in the patients with “3/6” or “6/6” in comparison to the patients with other genotypes. These results suggest that the IFN-γ gene region may contribute to the pathogenesis of IDDM and could be a genetic marker for IDDM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418381
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lack of association of the insulin gene region with Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects (1994)
    Springer
    Diabetologia 37 (1994), S. 210-213 
    Details
    ISSN: 1432-0428
    Keywords: Key words Insulin gene, polymorphism, Type 1 (insulin-dependent) diabetes mellitus, Japanese, susceptibility.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although the insulin gene region is implicated in susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Caucasians, significance of this region to Type 1 diabetes in Japanese remains unclear because the class 1 alleles (shorter insertion) of the variable number of tandem repeat in the 5′ region of the insulin gene are predominant in both diabetic and non-diabetic subjects. The 5′ insulin gene polymorphism was analysed in 75 Japanese patients and 69 control subjects with a precise method using PvuII and a polymorphism specific probe, which enabled us to divide class 1 alleles into four subclasses. Allelic frequencies were not significantly different between Type 1 diabetic patients and control subjects. The polymorphism in the 3′ untranslated region of the insulin gene (1127/ PstI) was also analysed and found to be tightly linked to the 5′ insulin gene polymorphism, and thus was not associated with diabetes. Interaction between HLA-DR and the insulin gene region, which was reported in the French study, was not observed in Japanese. These results suggest that the insulin gene region is not a valuable genetic risk factor for Type 1 diabetes in Japanese. [Diabetologia (1994) 37: 210–213]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050095
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Metacarpal bone mass in normal and osteoporotic Japanese women using computed X-ray densitometry (1994)
    Springer
    Calcified tissue international 55 (1994), S. 324-329 
    Details
    ISSN: 1432-0827
    Keywords: Photodensitometry ; Radiogrammetry ; Metacarpal bone ; Bone mineral density ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract The metacarpal bone mineral density (BMD) and metacarpal index (MCI) of the second metacarpal bone were measured by computed X-ray densitometry (CXD) (Teijin Ltd., Tokyo), which we have established with the development of microdensitometry of radiographs. In this study, we evaluated the basic attributes of this CXD method and determined the age-related changes in both metacarpal measurements in normal Japanese women. The precision in vivo was measured in eight subjects. The precision errors [coefficient of variation (CV)] were 0.2–1.2% CV for metacarpal BMD and 0.4–2.0% CV for MCI, respectively. We have obtained low precision error and more rapid analysis, within 3 minutes respectively, compared with the previous methods. Age-related changes in the metacarpal measurements were evaluated in 1438 normal women. Both measurements showed the most significant decrease in the sixth decade of life. The rate of decrease in the sixth decade was 1.6%/year for metacarpal BMD and 1.5%/year for MCI. On comparison between metacarpal BMD by CXD and spine BMD using dual energy X-ray absorptiometry (DXA) in 248 normal women with and without menstruation, the two measurements were found to be similarly decreased in the subjects within 5 years after menopause. There was also no significant difference in the Z-score between metacarpal BMD and spine BMD within 5 years after menopause. These results indicate that early postmenopausal bone loss occurs not only in the spine but also in the metacarpal bone. The metacarpal BMD for patients with osteoporosis was significantly lower than that for age-matched normal controls, although the Z-score for spine BMD (-1.46) was significantly better than that for metacarpal BMD (-0.82). In conclusion, because CXD has excellent low precision error and is widely available at relatively low cost, it appears potentially to be applicable to problems in the diagnosis and management of osteoporosis, when used in association with DXA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299308
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    Paper (German National Licenses)
    Fulltext
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