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  • 1
    Electronic Resource
    Electronic Resource
    Natural history of carpal tunnel syndrome according to the neurophysiological classification (1998)
    Springer
    Neurological sciences 19 (1998), S. 357-361 
    Details
    ISSN: 1590-3478
    Keywords: Carpal tunnel syndrome ; Natural history ; Neurophysiological classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Sebbene siano stati effettuati molti studi sulla sindrome del tunnel carpale (STC), in letteratura sono riportati pochi dati sulla storia naturale di tale patologia. La conoscenza dell'evoluzione naturale ha molte implicazioni cliniche e terapeutiche. Abbiamo eseguito prospetticamente il follow-up di 80 mani affette da STC non trattate. La valutazione è stata basata su un questionario auto -somministrato e sull'esame neurofisiologico. Le mani sono state divise secondo la classificazione neurofisiologica in STC negativa, minima, lieve, medio, grave, estrema. Il peggioramento è apparso inversamente correlato al grado di sofferenza del nervo, al contrario il miglioramento è apparso proporzionale alla compromissione della funzione nervosa (ad eccezione dei casi estremi the non sono mai migliorati), circa un terzo dei casi lievi e medi sono migliorati. La maggior parte dei casi minimi sono rimasti neurofisiologicamente invariati. Le nostre osservazioni suggeriscono che in una buona percentuale dei casi affetti da STC avviene un'autolimitazione della sindrome. I nostri dati suggeriscono ulteriori studi sulla naturale evoluzione di questa comune patologia.
    Notes: Abstract Although many studies on carpal tunnel syndrome (CTS) have been reported, few data on the natural history of CTS are available. Knowledge of the natural course of the disease has significant clinical and therapeutic value. We prospectively followed up 80 cases of untreated CTS. The evaluation was based on self-administered questionnaires and on neurophysiological investigation. According to the neurophysiological classification, cases of CTS were divided into six groups on the basis of impairment severity: negative, minimal, mild, moderate, severe, and extreme. Disease worsening was inversely related to severity of nerve entrapment. On the contrary, improvement was proportionally related to nerve function impairment (except for extreme cases that never improved), and about one-third of mild and moderate cases improved. Most minimally cases remained neurophysiologically unchanged. We hypothesize that in a good percentage of CTS cases, nerve impairment is self-limited. Our data suggest the utility of further studies on the natural course of this common disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02341782
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  • 2
    Electronic Resource
    Electronic Resource
    Neurotrophic Factors and Clinical Recovery in Relapsing-Remitting Multiple Sclerosis (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 62 (2005), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pathogenic autoimmune cells are demonstrated to be able to produce neurotrophic factors during acute phase of multiple sclerosis (MS). In this study, we determined the production of various neurotrophins [brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF), neurotrophin 3 (NT3) and neurotrophin 4 (NT4)] and some pro-inflammatory cytokines [tumour necrosis factor-α (TNF-α) and interferon-γ (IFN-γ)] by unstimulated peripheral blood mononuclear cells (PBMC) in 21 relapsing-remitting MS patients during different phases of disease (stable, relapse and post-relapse). During acute phase of disease, we detected a considerable increase of BDNF, TNF-α and IFN-γ production, while significantly higher levels of GDNF, NGF, NT3 and NT4 were found in post-relapse phase. When neurotrophin production was correlated with clinical outcome (complete or partial recovery from new symptoms), we found a significantly higher BDNF production in relapse phase followed by increased GDNF, NGF, NT3 and NT4 levels during post-relapse phase in subjects with complete remission only. During relapse phase, we detected a significant increase of pro-inflammatory cytokines, that was more evident in patients with partial recovery. The neuroprotective potential of immune cells seems to be inversely correlated with disease duration and with the age of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.2005.01649.x
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  • 3
    Electronic Resource
    Electronic Resource
    THYMOCYTE SUBSET IN MY ASTHENIA GRAVIS PATIENTS (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 377 (1981), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1981.tb33799.x
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  • 4
    Electronic Resource
    Electronic Resource
    Usefulness of segmental and comparative tests in the electrodiagnosis of carpal tunnel syndrome: the Italian multicenter study (1999)
    Springer
    Italian journal of neurological sciences 20 (1999), S. 315-320 
    Details
    ISSN: 1126-5442
    Keywords: Key words Carpal tunnel syndrome ; Symptom ; Hand function ; Multicenter ; Patient-oriented ; Classification ; Neurophysiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Italian CTS Study Group performed a wide multicentric and multiparametric study to quantify the increase of electrodiagnostic sensitivity using an extended neurophysiological protocol and particularly segmental and comparative tests. The study also evaluated the clinical features of carpal tunnel syndrome (CTS) diagnosed by these tests, using validated physician- and patient-oriented measurements. The study group was composed of 740 patients for a total of 1123 idiopathic CTS hands. Overall, the sensitivity of standard tests (median digit-wrist sensory conduction velocity and wrist-thenar distal motor latency) was 83.5%. Comparative/segmental tests disclosed abnormal findings in a further 11.4% of cases, providing CTS electrodiagnosis in about 7 of 10 “standard negative” cases. The overall sensitivity of the electrodiagnostic protocol was 94.9%. The CTS population diagnosed by segmental/comparative tests had a clinical picture characterized by a high percentage of pain, and severe discomfort but no limitation in functional daily activity. Our data confirm the usefulness of a complete neurophysiological assessment by using segmental/comparative tests when standard tests yield normal results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100720050047
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  • 5
    Electronic Resource
    Electronic Resource
    Italian multicentre study of carpal tunnel syndrome: clinical-neurophysiological picture and diagnostic pathway in 461 patients and differences between the populations enrolled in the northern, central and southern centres (1999)
    Springer
    Italian journal of neurological sciences 20 (1999), S. 309-313 
    Details
    ISSN: 1126-5442
    Keywords: Key words Carpal tunnel syndrome ; Multicentre ; Neurophysiology ; Cost ; Schooling ; Italy ; Diagnosis ; Patient-oriented ; Italian CTS Study Group
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The economic trend in our country, as in other countries, now requires us to pay more attention to the social and economic aspects of health. Therefore, it is important to evaluate the diagnostic pathway and the socio-economic aspects of pathologies. The Italian CTS Study Group performed a wide multicentre and multidimensional study (through a patient-, physician- and neurophysiologically oriented evaluation) on 461 idiopathic CTS patients to evaluate the clinical-neurophysiological picture and the diagnostic pathway. The whole population and the differences between the populations enrolled in the neurophysiological centres of the northern, central and southern parts of Italy were analysed. This study provided new and interesting information. As concerns the whole population, we observed different diagnostic pathways in relation to the level of schooling. As concerns the comparison of the populations, the southern centres have a population of CTS patients with higher frequency of hand stress and more severe nerve impairment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100720050046
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  • 6
    Electronic Resource
    Electronic Resource
    Outcome research and patient-oriented measures in the multiperspective assessment of neurological and musculoskeletal disorders (1999)
    Springer
    Italian journal of neurological sciences 20 (1999), S. 139-140 
    Details
    ISSN: 1126-5442
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: For the Consensus Conference: Third Roman Neurophysiology Day, Outcome Research in Neurology and in Musculoskeletal Disorders – 24 October 1998 Members and affiliations: P. Altrudo, Institute of Occupational Medicine UCSC, Rome; I. Aprile, Neurology Institute UCSC, Rome; L. Aulisa, Orthopedics Institute UCSC, Rome; E. Beghi, Clinical Neurology Hospital S. Gerardo, Monza, Institute M. Negri, Milan; M.R. Camelliti, Institute of Occupational Medicine UCSC, Rome; S. Capici, Institute of Orthopedics, Università La Sapienza, Rome; T. Carboni, Neurology Civil Hospital, San Benedetto del Tronto; I. Caruso, Institute of Physical and Rehabilitative Medicine, University Tor Vergata, Rome; E. Ceccarelli, Orthopedics Institute UCSC, Rome; M. Cianfanelli, Clinical Orthopedics Hospital S. Camillo, Rome; C. Conti, Institute of Orthopedics UCSC, Rome; D. D'Amico, Neurological Institute C. Besta, Milan; D. Dell'Acqua, Institute of Orthopedics UCSC, Rome; C. Foti, Institute of Physical and Rehabilitative Medicine, University Tor Vergata, Rome; A. Insola, CTO, Rome; M. Lo Monaco, Neurology Institute UCSC, Rome; R. Marrocco, Institute of Orthopedics UCSC, Rome; M. Montone, Institute of Occupational Medicine UCSC, Rome; L. Motti, Reggio Emilia; D. Murasecco, Clinical Neurology University of Perugia; M. Paciello, Hospital S. Carlo, Potenza; N. Paciello, Neurology Institute UCSC, Rome; P. Pasqualetti, A.Fa.R Osp. Fatebenefratelli Isola Tiberina, Rome; P. Pinelli, Fondazione S. Maugeri, Veruno (NO); A. Pizzoli, Institute of Orthopedics, University of Verona; E. Romanini, Institute of Orthopedics UCSC, Rome; S. Servidei, Neurology Institute UCSC, Rome; C. Speranzini, Hospital A. Murri, Fermo (AP).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100720050022
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  • 7
    Electronic Resource
    Electronic Resource
    Autosomal recessive hypermyelinating neuropathy (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 337-342 
    Details
    ISSN: 1432-0533
    Keywords: Key words: Polyneuropathy – Hereditary motor and sensory neuropathy – Demyelination – Myelin sheath foldings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We studied three patients from two kinships, affected by early onset hereditary motor and sensory neuropathy with probable autosomal recessive inheritance (HMSN type III). Morphological studies of sural nerve biopsies revealed an abnormal myelin proliferation. Two adult patients with long-term follow up, lost ability to walk at 28 and 22 years and showed severe involvement of the cranial nerves. Our observations suggest that "hypermyelination neuropathy" with early onset is a progressive disease with poor long-term prognosis. In one kinship the occurrence of the disease in two sibs of both sexes but not in parents, is consistent with an autosomal recessive inheritance. Familial cases of hypermyelination neuropathy have not been described in previous reports. Morphological aspects of this condition are compared with other forms of hypermyelination neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313601
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  • 8
    Electronic Resource
    Electronic Resource
    Reducing body myopathy and desmin storage in skeletal muscle: morphological and biochemical findings (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 106-112 
    Details
    ISSN: 1432-0533
    Keywords: Key words: Reducing body myopathy – Desmin storage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We describe clinical, morphological and biochemical findings of a patient with reducing body myopathy (RBM). This 15-year-old patient was affected by severe limb-girdle progressive myopathy with asymmetric distribution. Muscle biopsy showed many fibers with cytoplasmic polymorphic masses, which stained dark purple with modified Gomori's trichrome, associated with proliferation of cytoplasmic bodies. Cytoplasmic polymorphic masses showed marked reducing activity with menadione-nitro blue tetrazolium reaction. Ultrastructurally, there was great amount of highly electron-dense tubular-filamentous structures of 16 – 17 nm in diameter. Immunohistochemistry showed that many fibers were positive for desmin. Sodium dodecyl sulfate-electrophoresis disclosed an increase in two bands of approximately 53 and 70 kDa, and Western blot demonstrated that the 53-kDa band was desmin. It was not possible to characterize the 70-kDa protein further.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00386261
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  • 9
    Electronic Resource
    Electronic Resource
    Peripheral nerve findings in hereditary coproporphyria (1984)
    Springer
    Acta neuropathologica 63 (1984), S. 96-107 
    Details
    ISSN: 1432-0533
    Keywords: Hereditary coproporphyria ; Hereditary hepatic porphyrias ; Sural nerve biopsy ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In spite of several cases reported in the literature, the exact pathogenetic mechanism of neuropathic changes in porphyric neuropathy remains uncertain. Various authors have ascribed the neuropathologic findings to either a dying-back axonal degeneration or segmental demyelination. In recent years, the hypothesis of an axonal and myelinic disorder has received support by the demonstration of a combined and simultaneous involvement of both these structures. Such different opinions are also a consequence of the reduced number of detailed bioptic observations in the different forms of acute porphyria not only during acute phases but also between attacks. In this paper we report the results of light- and electronmicroscopic examination of two sural nerve biopsies from subjects with hereditary coproporphyria. The first was performed 6 months after an acute attack, the second specimen was obtained from a patient without acute attacks, who had clinical and electrophysiologic signs of a chronic progressive neuropathy. In both cases a dying-back axonal degeneration is considered the primary change. The pathogenetic mechanism of peripheral nerve lesions in porphyric neuropathy will be discussed finally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00697191
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  • 10
    Electronic Resource
    Electronic Resource
    Reducing body myopathy and desmin storage in skeletal muscle: morphological and biochemical findings (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 106-112 
    Details
    ISSN: 1432-0533
    Keywords: Recuding body myopathy ; Desmin storage peripheral nerves [3, 16, 20] ; We describe a new condition of desmin storage in a patient with typical reducing body myopathy (RBM)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe clinical, morphological and biochemical findings of a patient with reducing body myopathy (RBM). This 15-year-old patient was affected by severe limb-girdle progressive myopathy with asymmetric distribution. Muscle biopsy showed many fibers with cytoplasmic polymorphic masses, which stained dark purple with modified Gomori's trichrome, associated with proliferation of cytoplasmic bodies. Cytoplasmic polymorphic masses showed marked reducing activity with menadione-nitro blue tetrazolium reaction. Ultrastructurally, there was great amount of highly electron-dense tubular-filamentous structures of 16–17 nm in diameter. Immunohistochemistry showed that many fibers were positive for desmin. Sodium dodecyl sulfate-electrophoresis disclosed an increase in two bands of approximately 53 and 70 kDa, and Western blot demonstrated that the 53-kDa band was desmin. It was not possible to characterize the 70-kDa protein further.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00386261
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    Paper (German National Licenses)
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