ISSN:
1432-2277
Keywords:
Key words HLA class I matching
;
Cadaveric renal transplant
;
Crossreactive antigens (CREG)
;
Flow cytometric crossmatch (FCXM)
;
Anti-HLA alloantibodies
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Donor-recipient HLA matching was retrospectively evaluated in 111 cadaveric renal transplants using Takemoto's ten-residue model in which HLA class I antigens are clustered by crossreactive group (CREGs) on the basis of amino acid sequence homology and the sharing of a particular public epitope. The grade and type of HLA residue mismatching were correlated to posttransplant, class I donor-specific antibody production (monitored by flow cytometry crossmatch), rejection occurrence and clinical outcome during the 1st year posttransplant. In 52 patients with 0 mismatchings (MMs) we observed a low incidence of rejection (11.1 %) and antibody production (11.1 %) for 0 CREG MM grade, while 1 MM was enough to increase immune response against graft (rejection 35 %; antibodies 30 %). Moreover, a significant correlation was observed between Q144, E163, Q62 and L82/R82 epitopes and the incidence of acute rejection and antibody production (“immunogenic” residues) in patients grouped for a single residue mismatch.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001470050379
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