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Corneal infection of herpes simplex virus type 2 – induced neuronal apoptosis in the brain stem of mice with expression of tumor suppressor gene (p53) and transcription factors (2000)

Watanabe, Daisuke ; Honda, Takashi ; Nishio, Koji ; [et al.]

Springer

Acta neuropathologica 100 (2000), S. 647-653

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ISSN: 1432-0533

Keywords: Key words HSV ; Immunohistochemistry ; Apoptosis ; p53 ; Transcription factors

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract To understand the mechanism of neuronal apoptosis induced by herpes simplex virus (HSV) infection in vivo, the distribution of viral antigen, the appearance of apoptotic bodies, and the expressions of the tumor suppressor gene p53 and several transcription factors such as c-fos, c-jun and NF-κB were examined immunohistochemically and histopathologically after corneal infection of mice with HSV type 2 strain 186. Five days after HSV infection, viral antigen was diffusely detected in the corneal epithelium, the trigeminal ganglion and the pars caudalis of the spinal trigeminal nucleus. Neuronal apoptosis was observed in the brain stem ipsilateral to the HSV-infected side with the immunoreactivities of c-fos, c-jun, NF-κB and p53. Dual-labeling immunohistochemical studies revealed that almost all of the viral antigen-positive neurons and glia in the brain stem also showed p53 immunoreactivity. On the other hand, no neuronal apoptosis but only with the expression of c-jun was found in the trigeminal ganglion. Our results suggest that the different expression of transcription factors between the brain stem and the trigeminal ganglion may influence the neuronal apoptosis induced by HSV infection.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004010000240

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High-resolution transmission electron microscopy of hexagonal and rhombohedral molybdenum disulfide crystals (1993)

Isshiki, Toshiyuki ; Nishio, Koji ; Saijo, Hiroshi ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Microscopy Research and Technique 25 (1993), S. 325-334

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ISSN: 1059-910X

Keywords: HRTEM ; Molybdenite ; Synthesized MoS2 ; Stacking fault ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Natural Sciences in General

Notes: Natural (molybdenite) and synthesized molybdenum disulfide crystals have been studied by high-resolution transmission electron microscopy. The image simulation demonstrates that the [0001] and [0110] HRTEM images of hexagonal and rhombohedral MoS2 crystals hardly disclose their stacking sequences, and that the [2110] images can distinguish the Mo and S columns along the incident electron beam and enable one to determine not only the crystal structure but also the fault structure. Observed [0001] images of cleaved molybdenite and synthesized MoS2 crystals, however, reveal the strain field around partial dislocations limiting an extended dislocation. A cross-sectional image of a single molecular (S-Mo-S) layer cleaved from molybdenite has been observed. Synthesized MoS2 flakes which were prepared by grinding have been found to be rhombohedral crystals containing many stacking faults caused by glides between S/S layers. © 1993 Wiley-Liss, Inc.

Additional Material: 10 Ill.