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  • Key words Pharmacotherapy – obesity – appetite suppressant – thermogenesis  (1)
  • Nutzen  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 38 (1999), S. 1-13 
    ISSN: 1436-6215
    Keywords: Key words Pharmacotherapy – obesity – appetite suppressant – thermogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Many new substances are currently being investigated for their usefulness in the pharmacotherapy of obesity. Most drugs interfere with monoamine neurotransmitter (serotonin, noradrenalin, dopamine and histamine) effects and act as an appetite suppressant. Other approaches are to primarily increase thermogenesis (e.g. β3-adrenoceptor agonists), or to decrease fat absorption by inhibiting the pancreatic lipase (orlistat). New promising agents are substances that increase the effect of corticotropin releasing factor (CRF) or urocortin in the brain (CRF-binding protein ligand inhibitor) and a neuropeptide Y (NPY) Y5 receptor antagonist. The clinical relevance of leptin in the therapy of obesity is probably limited, but can not be fully evaluated at the moment. As obesity has a multifactorial basis, all these substances have in common the fact that they can not cure obesity. They should only be used as an adjunct to classical strategies like diet and exercise in severe obesity. For developing new, perhaps even more specific pharmacological agents, further research is needed to understand the individually different genetic and physiological basis of obesity.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Elektrokrampfbehandlung ; Ältere Patienten ; Depression ; Nutzen ; Risiken ; Key words Electroconvulsive therapy ; Elderly patients ; Depression ; Benefits ; Risks
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Between January 1995 and June 1996, 24 inpatients at our hospital (mean age 55.6 years) were treated with electroconvulsive therapy (ECT). Clinical improvement was observed in 80% of the patients, including those without risk factors (NRG, n=16), as well as those with concomitant cardiovascular diseases (RG, n=8). During a mean period of observation of 224 days after the end of ECT 7 patients (35%) relapsed. The rate of relapse was higher in RG than in NRG patients (57.1 vs 23.1%). In all cases ECT was well tolerated; 285 applications of ECT did not result in mortality or persistent morbidity. However, RG patients may be at increased risk for the development of minor cardiovascular complications, which were noted in three RG patients (37.5%), but only in one patient (6.2%) in the NRG (Fisher’s test, P=0.09). Taken together, our results demonstrate that ECT is a safe treatment regimen for depression even in medically ill patients of old age.
    Notes: Zusammenfassung Vierundzwanzig Patienten (Altersdurchschnitt 55,6 Jahre) wurden im Zeitraum 1/95 bis 6/96 an unserer Klinik mit der Elektrokrampftherapie (EKT) behandelt. Sowohl Risikopatienten mit kardiovaskulären Begleiterkrankungen (RG, n=8) als auch Patienten mit p.d. nicht erhöhtem Risiko (NRG, n=16) zeigten in über 80% der Fälle eine klinische Besserung. Bei 7 (35%) dieser Patienten kam es während des mittleren Beobachtungszeitraumes von 224 Tagen nach Abschluß der 1. EKT-Serie zu einer erneuten Exazerbation der psychischen Störung. Dabei zeigten RG-Patienten eine höhere Rückfallquote im Vergleich zu Patienten der NRG (57,1% vs. 23,1%). In allen Fällen konnte die EKT regulär beendet werden; bei insgesamt 285 durchgeführten EKT traten keine schwerwiegenden Komplikationen auf. Allerdings hatten RG-Patienten im Vergleich zu Patienten der NRG ein höheres Risiko für das Auftreten geringfügiger kardialer Komplikationen (37,5% vs. 6,2%, Fisher’s Test p=0,09). Zusammenfassend demonstrieren unsere Ergebnisse, daß die EKT auch bei Risikopatienten eine sichere Behandlungsmethode ist.
    Type of Medium: Electronic Resource
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