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  • Mus musculus  (5)
  • Life and Medical Sciences  (4)
  • Whipple's disease  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Whipple's disease: A report of 22 patients (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 533-539 
    Details
    ISSN: 1432-1440
    Keywords: Intestinal lipodystrophy ; Whipple's disease ; Atypical mycobacteria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-two patients with Whipple's disease are reviewed (21 male, 1 female; mean age 49.3 years). All but one were diagnosed by small intestinal biopsy. The most frequent clinical symptoms at diagnosis were weight loss (14/21 patients), diarrhea (13/21), arthralgias (13/21), cramping abdominal pain (11/21), and skin pigmentation (8/21), which anteceded the diagnosis by from 6 months to 10 years (median 3.5 years). All but three patients were treated successfully with tetracycline given for at least 2 years. Follow-up was done for a median of 7.7 years (range 1–15 years). Two of 17 patients who were followed for 2 years relapsed, as did 2/11 followed for at least 5 years. One patient relapsed twice. Each relapse could be treated with success. In no case did relapse occur in the central nervous system. Thus, tetracycline appears to be effective in the treatment of Whipple's disease if given for at least 2 years. In two further patients with confirmed central nervous system involvement at diagnosis, who were treated with ampicillin plus chloramphenicol, characteristic SPC cells disappeared from the cerebrospinal fluid. In addition, the recently recognized problems in the differential diagnosis of Whipple's disease and atypical mycobacterial infection in AIDS patients are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01736522
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  • 2
    Electronic Resource
    Electronic Resource
    Histology of intestinal whipple's disease revisited (1996)
    Springer
    Virchows Archiv 429 (1996), S. 334-343 
    Details
    ISSN: 1432-2307
    Keywords: Whipple's disease ; Tropheryma whippelii ; SPC cells ; Pathology ; Endoscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Whipple's disease is an infectious disorder with intestinal and extra-intestinal manifestations. We reinvestigated the intestinal histology in a series of 48 patients (10 females, 38 males; mean age 56.5 years, standard deviation of the mean ± 11.2 years). A total of 126 biopsy samples, obtained prior to, during, and after therapy, were evaluated by light microscopy. In 43 patients (90%), histology was consistent with common descriptions, while it was uncommon in 3 patients (6%), and non-diagnostic in 2 patients (4%). During treatment, several alterations occurred. Apart from a continuous decrease in PAS-positive macrophages, the pattern of mucosal infiltration changed from diffuse to patchy. Moreover, the cytological aspects of PAS-positive macrophages changed substantially, and this change was used to propose four different subtypes. Initially, subtype 1 macrophages predominated (74%), but showed a gradual decrease within a few months of therapy. After 15 months, subtype 3 and subtype 4 macrophages predominated (〈80%). In 7 of 9 patients followed over long periods some subtype 3 or subtype 4 macrophages persisted. It is concluded that at diagnosis and during treatment the intestinal histology of Whipple's disease is heterogeneous. A few PAS-positive macrophages commonly persist at long-term follow-up. This and other features suggest the presence of a persistent immune defect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198437
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  • 3
    Electronic Resource
    Electronic Resource
    Klinisch-immunologische und elektronenmikroskopische Untersuchungen bei Morbus Whipple (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 672-677 
    Details
    ISSN: 1432-1440
    Keywords: Whipple's disease ; electron microscopy ; immunology ; immunohistology ; Morbus Whipple ; Elektronenmikroskopie ; Immunologie ; Immunhistologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Berichtet wird über den ungewöhnlichen Verlauf eines Morbus Whipple. Unter antibiotischer Therapie tritt klinisch eine völlige Beschwerdefreiheit ein. Mehrfache Kontrollbiopsien zeigen eine hochgradige und progrediente Kollagenisierung des Stratum proprium mucosae, die besonders auch pericellulär und im Bereich der epithelialen Basalmembran entwickelt ist. Lymphocyten, Plasmazellen und interepitheliale lymphoide Rundzellen sind stark vermehrt. Immunologisch ist Serum-Komplement (C3-Fraktion) erniedrigt. Immunhistologisch findet sich nach Inkubation mit Patientenserum eine cellulär-cytoplasmatische Fluorescenz mit Anti-Komplement von subepithelial und interepithelial gelegenen Zellen. Die Befunde werden im Sinne eines hyperreaktiven Vorganges, der möglicherweise zur Induktion eines cellulären Immunmechanismus geführt hat, diskutiert.
    Notes: Summary An unusual course of Whipple's disease is reported. All clinical symptoms disappear with antibiotic therapy. Multiple control biopsies show a high grade and progressive collagen formation of the stratum proprium mucosae which takes places especially in the pericellular region and near the epithelial basal membrane. The number of lymphocytes, plasma cells and interepithelial lymphoid round cells is increased considerably. Immunologically the serum complement (C3-fraction) is decreased. Immunohistologically subepithelially and interepithelialy situated cells are found after incubation with the patients serum showing a cellular-cytoplasmatic fluorescence with anti-complement. These findings are discussed as a hyperreactive mechanism possibly leading to induction of a cellular immune process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468478
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  • 4
    Electronic Resource
    Electronic Resource
    Esterase-16 (Es-16): Characterization, polymorphism, and linkage to chromosome 3 of a kidney esterase locus of the house mouse (1981)
    Springer
    Biochemical genetics 19 (1981), S. 1091-1099 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; esterase ; Es-16 ; Chr. 3
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A polymorphism for an isozyme of a presumed arylesterase, esterase-16 (EC 3.1.1.2), has been detected in kidney, heart, and spleen of the house mouse, Mus musculus, by means of isoelectric focusing and by disc electrophoresis. Three phenotypes can be distinguished: the ES-16A phenotype (IEP 5.9) was found in C57BL/10Sn and many other laboratory inbred strains; the ES-16B phenotype (IEP 6.1) was found in M. m. molossinus; and the ES-16C phenotype (IEP 5.9; very weak activity) was found in Peru-Coppock. Esterase-16 is strongly inhibited by 10−3 m p-chloromercuribenzoate, but not by 2·10−4 m bis-p-nitrophenyl phosphate or by 10−3 m Diamox. It stains well with indoxyl acetate and other indigogenic substrates but only weakly with α-naphthyl acetate. Esterase-16 is completely insoluble in water. It is apparently governed by a structural gene locus, Es-16, with three alleles, Es-16 a , Es-16b, and Es-16 c, respectively. Es-16 is closely linked to Car-1 and Car-2 on chromosome 3. Typing of 94 animals of the backcross (C57BL/10Sn × M. m. mol.) F1 × M. m. mol. revealed a recombination frequency of 8.51±2.9%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484567
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  • 5
    Electronic Resource
    Electronic Resource
    Esterase-18 (ES-18) of the house mouse (Mus musculus): Biochemical characterization and genetics of an allozyme system linked to chromosome 19 (1988)
    Springer
    Biochemical genetics 26 (1988), S. 617-629 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; esterase-18 ; allozymes ; chromosome 19 ; gene order
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract This study describes the biochemical characterization, genetic variation, and linkage of a codominantly inherited murine esterase, termed ES-18. The enzyme was identified by isoelectric focusing of supernatants obtained after centrifugation of tissue homogenates and subsequent staining for esterase using either α-naphthyl acetate or 4-methylumbelliferyl elaidate as substrate. ES-18 exhibited an organ-specific variation of the intensity pattern of bands as seen in kidney, spleen, and macrophages, respectively. Its activity was highly sensitive to inhibition by 1 mmol · liter−1 p-chloromercuriphenyl-sulfonate but was resistant to bis-p-nitrophenyl phosphate. Four allozymes could be distinguished in kidney supernatants obtained from the inbred strains C57BL/10Sn (ES-18A), MOLF/Ei (ES-18B), WLL/BrA (ES-18C), and CAST/Ei (ES-18D). The enzyme is shown to be controlled by a structural locus,Es-18, which resides on chromosome 19. The gene orderLy-1—Got-1—4.7±1.6—Es-18 is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553784
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  • 6
    Electronic Resource
    Electronic Resource
    Esr, a second locus in the house mouse controlling esterase-5 (1982)
    Springer
    Biochemical genetics 20 (1982), S. 351-358 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; esterase-5 ; Esr locus ; chromosome 6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Electrophoretic variation characterized by the presence (ES-5B+) or absence (ES-5B−) of esterase-5B in the plasma of the house mouse has been observed. It is suggested that the expression of esterase-5B is controlled by an autosomal locus, Esr, linked to Ldr-1 on chromosome 6, in addition to the presumptive structural locus Es-5, which is located on chromosome 8. A gene order of Lyt-3-Esr-Ldr-1 was determined by two crosses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484429
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  • 7
    Electronic Resource
    Electronic Resource
    Esterase-18 (ES-18) of the house mouse (Mus musculus): Biochemical characterization and genetics of an allozyme system linked to chromosome 19 (1988)
    Springer
    Biochemical genetics 26 (1988), S. 617-629 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; esterase-18 ; allozymes ; chromosome 19 ; gene order
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract This study describes the biochemical characterization, genetic variation, and linkage of a codominantly inherited murine esterase, termed ES-18. The enzyme was identified by isoelectric focusing of supernatants obtained after centrifugation of tissue homogenates and subsequent staining for esterase using either α-naphthyl acetate or 4-methylumbelliferyl elaidate as substrate. ES-18 exhibited an organ-specific variation of the intensity pattern of bands as seen in kidney, spleen, and macrophages, respectively. Its activity was highly sensitive to inhibition by 1 mmol · liter−1 p-chloromercuriphenyl-sulfonate but was resistant to bis-p-nitrophenyl phosphate. Four allozymes could be distinguished in kidney supernatants obtained from the inbred strains C57BL/10Sn (ES-18A), MOLF/Ei (ES-18B), WLL/BrA (ES-18C), and CAST/Ei (ES-18D). The enzyme is shown to be controlled by a structural locus,Es-18, which resides on chromosome 19. The gene orderLy-1—Got-1—4.7±1.6—Es-18 is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02399606
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  • 8
    Electronic Resource
    Electronic Resource
    Esterase-23 (ES-23): Characterization of a new carboxylesterase isozyme (EC 3.1.1.1) of the house mouse, genetically linked to ES-2 on chromosome 8 (1984)
    Springer
    Biochemical genetics 22 (1984), S. 769-782 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; esterase ; temporal locus ; chromosome 8
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Genetic variation of a carboxylesterase isozyme (EC 3.1.1.1) of the house mouse, designated ES-23, is described. ES-23 was found in kidney, liver, and intestine. The isozyme was resistant to inhibition by 10−3 mol/liter eserine and was stained using α-naphthyl butyrate or 5-bromoindoxyl acetate as substrate. Five different phenotypes, ES-23A to ES-23E, could be distinguished by disc electrophoresis and by isoelectric focusing. ES-23 is controlled by a structural locus situated within the esterase gene cluster 2 on chromosome 8. An analysis of allele distribution among different strains suggested a separate structural locus for the isozyme, ES-23e, which is closely linked to the loci Es-2, Es-5, Es-7, and Es-11. Of the five phenotypes, only ES-23B was expressed in lung. This variation is apparently controlled by a cis-acting regulatory element, presumably a temporal locus, Es-23t, closely linked to the presumed structural locus Es-23e.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499472
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  • 9
    Electronic Resource
    Electronic Resource
    Stability of division-related protein and nucleic acid fractions in synchronized Tetrahymena (1967)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 70 (1967), S. 265-273 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The kinetics of RNA synthesis have been studied under various growth conditions using synchronized Tetrahymena pyriformis GL. The curves obtained are approximately linear in growth-supporting media but vary under other circumstances. The presence of amino acids in the medium stimulates RNA synthesis in Tetrahymena as it does in bacteria. Since these induced variations do not influence the essential features of the pre-cytokinetic period it is inferred that fluctuations in the rate of RNA synthesis described by others are probably not essential features of temperature-induced synchrony. In addition, the translational stability of division-related templates at synchronizing temperatures has been investigated. The synthesis of proteins necessary for cytokinesis is shown to be greatly reduced under conditions simulating a heat-shock. Inhibitor studies using cycloheximide indicate that protein synthesis is required longer into the cytokinetic phase than had previously been thought. Collectively the data are all compatible with the hypothesis that synthesis of division-related proteins is drastically reduced in heat-shocked Tetrahymena and that the basis for this reduction is hydrolysis of template RNA without concurrent translation.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040700306
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  • 10
    Electronic Resource
    Electronic Resource
    Temperature dependent RNA decay in TetrahymenaSupported by grant GM 06461-07 from the United States Public Health Service. (1966)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 68 (1966), S. 203-205 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040680215
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