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  • Mushroom  (1)
  • Mushroom poisoning  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Antagonistic effects against single lethal doses of Amanita phalloides (1976)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 293 (1976), S. 171-174 
    Details
    ISSN: 1432-1912
    Keywords: Amanita phalloides ; Mushroom ; Poisoning ; Antidotes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Agents with antagonistic effects against phalloidin or α-amanitin were tested in mice against lethal doses of an extract from the whole mushroom amanita phalloides. The following categories of agents reduced lethality after the extract. First, agents protecting only against phalloidin such as rifampicin, phenylbutazone and antamanide. Second, silymarin and prednisolone which display both antiamatoxic and marked (silymarin) or moderate (prednisolone) antiphallotoxic activity. Thioctic acid displayed some activity when tested against mid-lethal doses of the extract. Cytochrome c, a chemical with curative potencies against α-amanitin did not reduce the lethality of the extract. All of the effective agents acted only when applied prior to the poisoning. The pattern or protective activity would indicate that in mice death after single doses of Amanita phalloides may follow a qualitatively particular course which is difficult to ascribe to phallo- or amatoxic effects alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499223
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Ethanol diminishes the toxicity of the mushroomAmanita phalloides (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 1268-1270 
    Details
    ISSN: 1420-9071
    Keywords: Mushroom poisoning ; Amanita phalloides ; ethanol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Survival of mice after lethal doses of a lyophilizate fromAmanita phalloides (‘death cap’) was markedly increased by single doses of ethanol applied 30 min before or 5 min after the mushroom. Hepatic histopathological damage (confluent necrosis) was largley prevented. Acute, but not chronic, consumption of ethanol may thus influence favorably the outcome of death cap poisoning and should be taken into consideration in the evaluation of therapeutic measures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946668
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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