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  • Organic Chemistry  (6)
  • pharmacokinetics  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Metabolism of pindolol in patients with renal failure (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 423-428 
    Details
    ISSN: 1432-1041
    Keywords: pindolol ; renal failure ; metabolism ; pharmacokinetics ; 14C-pindolol ; blood metabolites ; urinary metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Increased metabolism of pindolol in renal impairment has previously been suggested by pharmacokinetic calculations. The present study was a pharmacokinetic and metabolic investigation in 7 patients with severe renal impairment (endogeneous creatinine clearance below 5 ml/min). All the patients received pindolol 5 mg t.d.s. 5 days. On the sixth day, after an overnight fast, 14C-pindolol 5 mg was given orally as a solution to drink. Blood samples were taken for up to 72 h and urine was collected at intervals up to 96 h for measurement of unchanged pindolol by a fluorimetric method and total radioactivity by liquid scintillation counting. Metabolites in blood and urine were analysed after separation by HPLC. It was found that the plasma levels following a single dose of 14C-pindolol were similar to those observed in healthy volunteers, but the elimination half-life was slightly increased up to 11.5 h. The observed steady state plasma concentrations of pindolol were twice as high but they are still in the therapeutic range of 10 to 100 ng/ml. Therefore, the dose of pindolol could have been reduced by a factor 2, but the reduction was not essential. No active metabolite of pindolol was found in plasma or urine, but elimination of the metabolites was decreased. The elimination half-life following multiple doses was prolonged compared to normal and it was quite comparable to that found for the pharmacodynamic half-life in renal patients. The discrepancy between the present findings and the previous results for metabolism and pharmacodynamic half-life was probably due to the sensitivity of the fluorimetric assay of pindolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542547
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of unlabelled and14C-labelled pindolol in uraemia (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 25-29 
    Details
    ISSN: 1432-1041
    Keywords: Pindolol ; uraemia ; pharmacokinetics ; β-blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The elimination of pindolol in 25 patients with various degrees of renal failure has been studied after an intravenous dose of 3 mg. A linear correlation was not found between the elimination rate of pindolol and the endogenous creatinine clearance, and the half-life of the unchanged drug was independent of the severity of the renal failure. This implies greater metabolism of pindolol in anuric patients and the extrarenal elimination rate constantk mwas increased. Three patients with severe renal failure were given 3 mg14C-pindolol. They showed almost constant plasma levels of radio-activity for 6 h and then slow excretion with a half-life of 48 h, because of accumulation of metabolites in the blood. Up to 90% of the metabolites are glucuronides and sulphates which have no beta-blocking or other clinical activity. Thus, to produce beta-adrenergic blockade the same dose of indolol is required in healthy patients as in those with uraemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614386
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  • 3
    Electronic Resource
    Electronic Resource
    Contribution à l'étude des glucosaminides (1952)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 35 (1952), S. 807-812 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Nous avons effectué la synthèse d'α- et de β-glucosaminides à partir des N-carbalcoxy-glucosamines et des α- et β-osides correspondants. Nous montrons que ces dérivés, très stables, ne présentent aucune mutarotation dans des conditions où les glucosides analogues en présentent une. Le groupe aminé de ces glucosaminides ne possède pas les propriétés caractéristiques d'une amine primaire. Tous ces faits rendent peu plausibles une structure glucosidique classique pour les glucosaminides.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19520350317
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  • 4
    Electronic Resource
    Electronic Resource
    Synthese einiger Methylimino-diessigsäurederivate (1952)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 35 (1952), S. 451-456 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wurde eine Methode zur Herstellung von Methylimino-diessigsäure-diäthylester-chlormethylat ausgearbeitet, das sich mit Aminoverbindungen zu einer Reihe neuer Derivate der Methylimino-diessigsäure umsetzen lässt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19520350206
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  • 5
    Electronic Resource
    Electronic Resource
    Herstellung von Iminen durch Gasphasen-Pyrolyse: N-Methyl-äthylidenimin (1968)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 51 (1968), S. 1686-1691 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: N-methyl-ethylidenimine (CH3—CH=N—CH3) was obtained by pyrolysis of 2-methylaziridine in a gas phase flow system, using quartz as a catalyst. Pyrolysis of aziridine gave mainly N-methyl-methylenimine (CH2=N—CH3). Under the conditions used in this work, pyrolysis of both compounds surprisingly showed cleavage of the CC-bond in the three-membered ring. No monomeric ethylidenimine (CH3—CH=NH) could be isolated by pyrolysis of trimeric ethylidenimine (2,4,6-trimethyl-hexahydro-1,3,5-triazine), whereas N-vinyl-ethylidenimine (CH3—CH=N—CH=CH2) could be identified as one of the pyrolysis products. NMR. data for N-methyl-ethylidenimine and N-vinyl-ethylidenimine are given for identification purposes.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19680510724
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  • 6
    Electronic Resource
    Electronic Resource
    N-Dimethylglycin-hydrazid-hydrochlorid, Reagenz zur Isolierung und Charakterisierung von Carbonyl-Derivaten (1950)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 33 (1950), S. 1773-1775 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird die Herstellung eines neuen Reagenzes, des N-Dimethylglycin-hydrazid-hydrochlorids beschrieben, das sich wie Girard-Reagenz zur Isolierung von Aldehyden und Ketonen eignet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19500330646
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  • 7
    Electronic Resource
    Electronic Resource
    Über Steroide und Sexualhormone. 204. Mitteilung. Zur Stereochemie der epimeren 17a-Methyl-D-homo-testosterone (1955)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 38 (1955), S. 411-420 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die aus 17 β-Oxy-pregnenolon durch Umlagerung des Gerüstes zugänglichen 17 a-Oxy-17-keto-D-homo-Steroide VI und XII wurden mit den beiden bekannten 17a-Methyl-D-homo-testosteronen I und II stereochemisch verknüpft. Damit konnte die bereits früher vorgenommene Konfigurationszuteilung an diese beiden D-Homo-androgene bestätigt werden.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19550380206
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  • 8
    Electronic Resource
    Electronic Resource
    Über Cyankomplexe des Rheniums und Darstellung von reinem Rhenium(I)-Komplex in Lösung (1955)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 38 (1955), S. 1679-1689 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die oxydimetrische Titration wässeriger Lösungen von Re2Cl6 in Alkalicyanidlösungen verschiedener Konzentration und Alkalität wurde untersucht. Es konnte gezeigt werden, dass die Oxydation bei geeignetem Überschuss an Alkalicyanid von dem zweikernigen Komplex [ReIICy4·ReIVCy4] ausgeht, in welchem die beiden Gruppen von je 4 CN- potentiometrisch mit Silbernitrat separat bestimmt werden konnten. Die Oxydation dieses Komplexes mit Ferricyanion führte nur bis zu [ReIVCy4·ReVCy4].
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19550380704
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