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  • Physics  (2)
  • Parietaria judaica  (1)
  • Toxicity-1,2-Dichloropropane-Glutathione-N-acetylcysteine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    cDNA cloning, expression and primary structure of Par j I, a major allergen of Parietaria judaica pollen
    Amsterdam : Elsevier
    FEBS Letters 341 (1994), S. 182-186 
    Details
    ISSN: 0014-5793
    Keywords: IgE antibody ; Parietaria judaica ; Pollinosis ; Primary structure ; Recombinant allergen ; cDNA
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)80453-2
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  • 2
    Electronic Resource
    Electronic Resource
    1,2-Dichloropropane (DCP) toxicity is correlated with DCP-induced glutathione (GSH) depletion and is modulated by factors affecting intracellular GSH (1990)
    Springer
    Archives of toxicology 64 (1990), S. 459-465 
    Details
    ISSN: 1432-0738
    Keywords: Toxicity-1,2-Dichloropropane-Glutathione-N-acetylcysteine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute 1,2-dichloropropane (DCP) poisoning in humans is relatively frequent in Italy, where DCP is widely diffused as a constituent of commercial solvents and dry cleaners. In this study we have investigated the effects of DCP on intracellular glutathione (GSH) content in main target tissues of male Wistar rats, i.e. liver, kidney and blood, in order to establish if a correlation between DCP-induced GSH depletion and tissue damage exists. Administration of DCP (2 ml/kg body weight orally) caused a dramatic loss of tissue GSH occurring 24 h after DCP intoxication, followed by a slow restoration approaching physiological levels after 96 h. GSH depletion was associated with a marked increase in serum GOT, GPT, 5′-nucleotidase, gamma-glutamyl transpeptidase, alkaline phosphatase, urea and creatinine, and a significant degree of hemolysis. When animals were pretreated with a GSH depleting agent, buthionine-sulfoximine (BSO) (0.5 g/kg body weight) i. p. 4 h before DCP intoxation, an increase of overall mortality was found, significantly different from the group of animals treated with DCP alone. On the contrary, the administration of a GSH precursor, N-acetylcysteine (NAC) i. p. (250 mg/kg body weight) 2 and 16 h after DCCP intoxication prevented the dramatic loss of cellular GSH and reduced the extent of injury in target tissues, as demonstrated by laboratory indices. Furthermore, statistical analysis of the data revealed a correlation between: (1) depletion of liver GSH and increase in serum GOT, GPT, 5′-nucleotidase, (2) depletion of kidney GSH and increase in serum urea and creatinine and (3) depletion of blood GSH and the occurence of hemolysis. Our findings demonstrate that GSH plays a critical role in modulating the toxicity of DCP. They also highlight the protective role of NAC and suggest that this glutathione precursor could rationally be employed in DCP poisoning in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01977627
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  • 3
    Electronic Resource
    Electronic Resource
    Co60 γ-radiation-induced copolymerization of ethylene and carbon monoxide (1966)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 4 (1966), S. 29-57 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The γ-radiation-induced free-radical copolymerization of ethylene and CO has been investigated over a wide range of pressure, initial gas composition, radiation intensity, and temperature. At 20°C., concentrations of CO up to 1% retard the polymerization of ethylene. Above this concentration the rate reaches a maximum between 27.5 and 39.2% CO and then decreases. The copolymer composition increases only from 40 to 50% CO when the gas mixture is varied from 5 to 90% CO. A relatively constant reactivity ratio is obtained at 20°C., indicating that CO adds 23.6 times as fast as an ethylene monomer to an ethylene free-radical chain end. For a 50% CO gas mixture, the above value of 23.6 and the copolymerization rate decrease with increasing temperature to 200°C. The kinetic data indicate a temperature-dependent depropagation reaction. Infrared examination of copolymers indicates a polyketone structure containing —CH2—CH2— and —CO— units. The crystalline melting point increases rapidly from 111 to 242°C., as the CO concentration in the copolymer increases from 27 to 50%. Molecular weight of copolymer formed at 20°C. increased with increasing CO, indicating M̄n values 〉20,000. Increasing reaction temperature results in decreasing molecular weight. Onset of decomposition for a 50% CO copolymer was measured at ≈250°C.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1966.150040103
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  • 4
    Electronic Resource
    Electronic Resource
    Radiation-induced copolymerization of ethylene and sulfur dioxide in the liquid and gas phases (1968)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 6 (1968), S. 3201-3215 
    Details
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The radiation-induced copolymerization of ethylene and sulfur dioxide has been studied in the liquid and gas phases. In the liquid phase, the copolymer composition remained equimolar over a temperature range of 20-160°C. and ethylene pressures of 50-680 atm. The rate of copolymerization in the liquid phase at 680 atm. increased with temperature to a maximum value at ∼80°C. Above this temperature the rate steadily decreased to zero at 157°C. because of temperature-dependent depropagation reactions. In the gas phase, copolymers were formed that contained from 9 to 46 mole-% sulfur dioxide. Under constant conditions of temperature, pressure, and radiation intensity, the copolymerization rate in the gas phase increased with increasing sulfur dioxide in the initial gas mixture. The propagating species for the liquid-phase experiments is considered to consist of an equimolar complex molecule of ethylene and sulfur dioxide. For gas mixtures containing an excess molar concentration of ethylene, the propagating species are ethylene and the complex molecule. Infrared spectra show polysulfone structures. Calorimetric and x-ray diffraction analyses indicate crystalline structures for copolymers in the range 9-50 mole-% sulfur dioxide, although a melt transition temperature could not be observed for copolymer containing 〉31 mole-% sulfur dioxide. Clear uniform film was obtained with copolymers containing up to 31 mole-% SO2.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1968.150061201
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