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Profile of acute tolerance to three sedative anxiolytics (1983)

Ellinwood, Everett H. ; Linnoila, Markku ; Easler, Martha E. ; [et al.]

Springer

Psychopharmacology 79 (1983), S. 137-141

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ISSN: 1432-2072

Keywords: Acute tolerance ; Peak impairment ; Sedative anxiolytics ; Plasma concentration

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component that is followed by a much slower blood-drug rise time. These pronounced early peak effects were not shared by alcohol, and contribute significantly to the lack of correlation between impairment and DPL.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00427800

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