ISSN:
1432-2072
Schlagwort(e):
Acute tolerance
;
Peak impairment
;
Sedative anxiolytics
;
Plasma concentration
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component that is followed by a much slower blood-drug rise time. These pronounced early peak effects were not shared by alcohol, and contribute significantly to the lack of correlation between impairment and DPL.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00427800
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