ISSN:
1432-2013
Keywords:
Aldosterone
;
Adrenalectomy
;
Sodium Transport
;
Tricarboxylic Acid Cycle
;
Enzyme Activity
;
Aldosteron
;
Adrenalektomie
;
Natriumtransport
;
Citronensäurecyclus
;
Enzymaktivität
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Description / Table of Contents:
Zusammenfassung In Nieren normaler und adrenalektomierter Ratten wurde die Aktivität des condensing enzyme, der TPN-Isocitrat-Dehydrogenase, DPN-Isocitrat-Dehydrogenase, Succinat-Dehydrogenase, Malat-Dehydrogenase, Glutamat-Oxalacetat-Transaminase, Glutamat-Dehydrogenase, β-Hydroxybutyrat-Dehydrogenase, α-Glycerophosphat-Oxydase, Glyceraldehydphosphat-Dehydrogenase, Lactat-Dehydrogenase, Pyruvat-Kinase und des malic enzyme bestimmt. Adrenalektomie bewirkt eine Abnahme der Aktivität des condensing enzyme um 44%, der TPN-Isocitrat-Dehydrogenase um 20%, der Glutamat-Oxalacetat-Transaminase um 23%, der Glutamat-Dehydrogenase um 23% und der Glyceraldehydphosphat-Dehydrogenase um 17%. Gabe von Aldosteron bei adrenalektomierten Tieren normalisiert die Aktivität des condensing enzyme, der TPN-Isocitrat-Dehydrogenase und der Glutamat-Dehydrogenase, die Aktivität der Glutamat-Oxalacetat-Transaminase und der Glyceraldehydphosphat-Dehydrogenase zeigt eine nicht zur Normalisierung ausreichende Steigerung. Außerdem wird die durch Adrenalektomie nicht veränderte Aktivität der Succinat-Dehydrogenase um 10% erhöht.
Notes:
Summary The activity of the following enzymes was determined in kidneys of normal and adrenalectomized rats: condensing enzyme, isocitrate dehydrogenase (NADP and NAD), succinate dehydrogenase, malate dehydrogenase, aspartate aminotransferase, glutamate dehydrogenase, hydroxybutyrate dehydrogenase, glycerophosphat dehydrogenase, glyceraldehydphosphat dehydrogenase, pyruvate kinase, lactate dehydrogenase, malate dehydrogenase (decarboxylating, NADP). Adrenalectomy lowers the activity of condensing enzyme by 44%, of isocitrate dehydrogenase (NADP) by 20%, of aspartate aminotransferase by 23%, of glutamate dehydrogenase by 23% and of glyceraldehydphosphat dehydrogenase by 17%. Aldosterone given to adrenalectomized rats normalises the activity of condensing enzyme, isocitrate dehydrogenase (NADP), and glutamate dehydrogenase, the activity of aspartate aminotransferase and glyceraldehydphosphat dehydrogenase increases without reaching the control levels. The activity of succinate dehydrogenase is not influenced by adrenalectomy but is augmented by aldosterone treatment of adrenalectomized animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00364297
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