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A low molecular weight heparin decreases plasma aldosterone in patients with primary hyperaldosteronism (1992)

Cailleux, N. ; Moore, N. ; Levesque, H. ; [weitere]

Springer

European journal of clinical pharmacology 43 (1992), S. 185-187

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Details

ISSN: 1432-1041

Schlagwort(e): Primary hyperaldosteronism ; plasma aldosterone ; low molecular weight heparin

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Four patients with primary hyperaldosteronism were treated with nadroparin 4100 or 6150 antiXa IU daily for 4 days. Plasma and urine sodium and potassium, and plasma aldosterone and renin were monitored before, during and after the study. After four days of treatment, and for the following two days, plasma aldosterone was decreased (by a mean of 49% on Day 6), and urinary Na/K was increased (3.7-fold). The direction of the changes was reversed on Day 8. The study has confirmed the effect of low molecular weight heparin on aldosterone, and makes it unlikely that it is related to inhibition of angiotensin II stimulation in these patients, as renin could not be detected in their plasma.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01740668

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