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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of clinical oncology 5 (2000), S. 164-170 
    ISSN: 1437-7772
    Keywords: Key words P-glycoprotein ; Osteosarcoma ; Soft-tissue sarcoma ; Prognosis ; Immunohistochemistry ; RT-PCR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. The purpose of this study was to investigate the correlation between P-glycoprotein status and outcome in adult patients with high-grade osteosarcomas and soft-tissue sarcomas. Methods. P-glycoprotein status was determined im-munohistochemically in specimens from 28 patients with osteosarcoma and 34 patients with soft-tissue sarcoma. The polyclonal antibody mdr(Ab-1) was used for either decalcified or undecalcified tissue samples which were formalin-fixed and paraffin-embedded. The expression of P-glycoprotein mRNA was also determined by the polymerase chain reaction in 23 fresh sarcoma specimens. P-glycoprotein status was analyzed in relation to the duration of event-free survival. Results. Positivity for P-glycoprotein was found in 29% of the osteosarcomas and 34% of the soft-tissue sarcomas. Consistent results were obtained at both the immunohistochemical and reverse transcriptase-polymerase chain reaction (RT-PCR) levels in 19 of 23 sarcomas (83%). In patients with osteosarcoma, the presence of increased levels of P-glycoprotein was significantly associated with a decreased probability of event-free survival after diagnosis (P = 0.022). In contrast, in patients with soft-tissue sarcoma there was no correlation between the level of P-glycoprotein and prognosis. Conclusions. In patients with high-grade osteosarcomas, the presence of increased levels of P-glycoprotein detected by polyclonal antibody mdr(Ab-1) was associated with a significantly increased risk of adverse events. This association was not found in patients with soft-tissue sarcomas.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1459
    Keywords: Guillain-Barré syndrome ; Nerve conduction velocity ; Prognosis ; Motor paralysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Klinisch-elektrophysiologische Untersuchungen wurden bei 39 Patienten mit Guillain-Barré Syndrom durchgeführt. Es ging um die Frage, welche Elemente in der akuten Phase eine prognostische Beurteilung zulassen. Bei 16 der Patienten, was 52% des Krankengutes entspricht, wurden residuelle Symptome wie motorische Schwäche, fehlende Patellarsehnenreflexe und so weiter nachgewiesen. Das Zurückbleiben von residuellen Symptomen korrelierte mit dem Alter bei Krankheitsbeginn, das Ausmaß der Tetraparese und das Ausmaß der Sensibilitätsstörungen in der akuten Phase. Acht der zehn Patienten, die eine Verminderung der motorischen Nervenleitgeschwindigkeit in einer frühen Krankheitsphase aufwiesen, zeigten später nennenswerte Restsymptome. Tendenzmäßig schienen Restsymptome häufiger bei jenen Patienten zu sein, welche eine Verlangsamung der Leitgeschwindigkeit gemischter Nerven und eine verlängerte Latenz der H-Welle sowie der Residuallatenz aufwiesen. Elektroneurographische Untersuchungen, im besonderen die Bestimmung der motorischen Leitgeschwindigkeit, erlauben zuverlässige Rückschlüsse auf die Prognose dieses Krankheitsbildes.
    Notes: Summary Clinical and electrophysiological studies were carried out on 39 patients with the Guillain-Barré syndrome to evaluate which elements were of prognostic value during the acute phase. Residual clinical signs such as motor weakness and absent patellar tendon reflexes were found in 16 (52%) of those patients who had had a preceding illness. Persistence of deficit was significantly correlated to age at onset, the degree of quadriparesis and loss of deep sensation in the acute phase. Of the 10 patients who showed a reduction in motor nerve conduction velocity (MCV) in the early stage, 8 (80%) revealed significantly residual clinical symptoms at follow-up. There was a tendency for the incidence of residual signs to be more common in the patients with slowing of mixed nerve conduction velocity, and prolonged latency of H-wave and the residual latency. Nerve conduction studies, especially measurement of MCV, were of value as a reliable prognostic indicator in this syndrome.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 255 (1998), S. 311-314 
    ISSN: 1434-4726
    Keywords: Key words Parotid tumors ; Immunohistochemistry ; Proliferating cell nuclear antigen ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the prognostic value of immunostaining proliferating cell nuclear antigen (PCNA) by using a monoclonal antibody (PC10) in patients with parotid tumors. Twenty-seven cases were studied. Immunohistochemical studies were carried out on paraffin-embedded tissues from the patients, and the PCNA index was calculated as the percentage of positively staining tumor cells. The PCNA index ranged from 0.1 to 65.3%. We divided the 27 lesions into three groups histologically: group A with benign pleomorphic tumors (11 cases), group B with low-grade malignant tumors (5 cases), and group C with high-grade malignant tumors (11 cases). The mean PCNA index was 0.7% in group A, 2.0% in group B, and 23.1% in group C. The clinical data revealed a significantly higher local tumor recurrence and mortality rate in group C than in groups A and B. We conclude that PCNA may be used as an important indicator for determining clinical prognosis in parotid tumors.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International journal of thermophysics 19 (1998), S. 1285-1295 
    ISSN: 1572-9567
    Keywords: HFC-134a ; Lennard–Jones potential ; viscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The viscosity of gaseous HFC-134a (1,1,1,2-tetrafluoroethane) was measured with an oscillating disk viscometer of the Maxwell type from 298.15 to 398.15 K at pressures up to 5.5 MPa. Intermolecular potential parameters for the Lennard–Jones 12-6 model were determined from the viscosity data at 0.1 MPa. The viscosity equation developed by Krauss et al. was applied to correlate the present viscosity data. In addition, the correlations proposed by Stiel and Thodos and by Lee and Thodos were tested for fitting the experimental viscosity data.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International journal of thermophysics 15 (1994), S. 603-626 
    ISSN: 1572-9567
    Keywords: critical anomaly ; mode-coupling theory ; nitrous oxide ; viscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The gaseous viscosity of nitrous oxide (N2O) was measured in the critical region. The experimental temperature range was between 309.650 and 318.150 K and the pressure range was up to 9.6 MPa. The measurements were obtained with an oscillating-disk viscometer, combined with local determination of the density at the position of the oscillating disk, and they have an estimated accuracy of 0.6 % for viscosity and 0.5 % for gas density. The viscosity of N2O exhibits an anomalous increase near the critical point. The anomalous increase in viscosity was analyzed with the viscosity equation proposed by Basu and Sengers.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of thermophysics 20 (1999), S. 435-443 
    ISSN: 1572-9567
    Keywords: corresponding states ; HFC-143a ; viscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The viscosity of gaseous HFC-143a(1,1,1-trifluoroethane) was measured with an oscillating-disk viscometer of the Maxwell type at temperatures from 298.15 to 423.15 K and at pressures up to the saturated vapor pressure at each temperature under subcritical conditions or up to 9 MPa under supercritical conditions. Intermolecular potential parameters of HFC-143a for the extended corresponding states were determined from the viscosity data at 0.1 MPa. An empirical viscosity equation as functions of temperature and density is proposed to interpolate the present experimental results.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of thermophysics 20 (1999), S. 445-453 
    ISSN: 1572-9567
    Keywords: corresponding states ; HFC-125 ; oscillating-disk viscometer ; viscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract This paper reports experimental results lor the viscosity of gaseous HFC-125 (pentafluoroethane) under high pressures. The measurements were carried out with an oscillating-disk viscometer of the Maxwell type at temperatures from 298.15 to 423.15 K and at pressures up to the saturated vapor pressures at each temperature at subcritical conditions or up to 9 MPa at supercritical temperatures. Intermolecular scaling parameters of HFC-125 for the extended corresponding states were determined from the viscosity data at 0.1 MPa. An empirical viscosity equation is proposed to interpolate the present experimental results as a function of temperature and density.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International journal of thermophysics 21 (2000), S. 695-701 
    ISSN: 1572-9567
    Keywords: HCFC-123 ; viscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The viscosity of gaseous HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) was measured with an oscillating-disk viscometer of the Maxwell type at temperatures from 323.15 to 423.15 K and at pressures up to the saturated vapor pressure at each temperature in subcritical conditions or up to 2 MPa under supercritical conditions.
    Type of Medium: Electronic Resource
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