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  • Quadrigeminal plate  (1)
  • Skull base lesions  (1)
  • Transsphenoidal endoscopic surgery  (1)
  • anti-sense DNA  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Child's nervous system 16 (2000), S. 686-691 
    ISSN: 1433-0350
    Keywords: Keywords Neuroendoscopy ; Skull base lesions ; Transsphenoidal endoscopic surgery ; Pediatric
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We describe the development of transnasal endoscopic approaches to the cranial base in an interdisciplinary series of 103 patients, including 13 in the pediatric age group. Our aim was to define, with the aid of different case reports, the possibilities of endoscopic techniques in tumor resection, fistula repair, the treatment of mucoceles and meningoceles, and of combined intracranial and endoscopic approaches. The advantages of these minimally invasive approaches are panoramic visualization, rapidity and reduction of the cosmetic and functional disabilities in comparison with other conventional approaches, and a better capacity for identifying and developing key landmarks for surgery. On the other hand, endoscopic surgery requires an exsanguine operation field, technical improvements in instruments, and specific skills. Interdisciplinary collaboration in endoscopic approaches has proved useful in integrating experiences without overlap between fields, and in broadening possibilities: in our opinion endoscopic approaches will certainly be important in the future of cranial base surgery.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Child's nervous system 16 (2000), S. 129-133 
    ISSN: 1433-0350
    Keywords: Key words Arteriovenous malformation ; Brain stem ; Cerebellum ; Children ; Quadrigeminal plate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  This report presents a case of arteriovenous malformation (AVM) in the region of the superior vermis and quadrigeminal plate, which was partially embolized using a endovascular technique and subsequently surgically excised. An occipital transtentorial approach was employed to excise the AVM, and the patient did well without neurological complications postoperatively. Comparing various surgical approaches, we believe the occipital transtentorial approach is the best for the AVM of this region.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1569-8041
    Keywords: anti-sense DNA ; growth factors ; invasion ; melanoma ; perlecan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Heparan sulfate proteoglycans are one of the major componentsof extracellular matrix and are secreted at different levels by severalnormal and tumoral cells. Perlecan, the basement membrane proteoglycan, hasstructural domains involved in cell/matrix interactions and growth factorstorage. Metastatic melanoma cells show an increase in perlecan expressionas compared to low metastatic ones. We examined whether reduction ofperlecan expression could down-modulate the malignant phenotype in melanomaclones. Materials and methods: We transfected B16-F10 murine malignant melanomacells with a perlecan antisense cDNA construct and tested the in vitrobehavior of the selected clones. Results: The expression of antisense mRNA corresponded to a reduction ofperlecan synthesis. The clones with reduced perlecan synthesis showed adown-regulation of proliferation and invasion. Conclusions: These results further indicate the importance of perlecan asa regulator of growth factor activity affecting the biological properties ofmetastatic cells, and suggest the potential use of antisense perlecan DNA inanti-melanoma gene therapy approaches.
    Type of Medium: Electronic Resource
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