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  • 1
    Electronic Resource
    Electronic Resource
    Radiation therapy of rat brain tumor using misonidazole as hypoxic cell sensitizer (1985)
    Springer
    Journal of cancer research and clinical oncology 109 (1985), S. 188-192 
    Details
    ISSN: 1432-1335
    Keywords: Experimental nervous system tumor ; Radiation therapy ; Misonidazole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rat brain tumor was used as a model to evaluate radiation therapy with and without misonidazole. BD-IX rats were implanted intracerebrally with an ethylnitrosourea-induced glioma. Three series of experiments were performed, with radiation given 14 days after inoculation of the glioma clone. In each series, the following radiation doses were given: 500 rads once, 1,000 rads once; and 1,000 rads twice, every time with or without two different doses of misonidazole. Radiation therapy significantly prolonged survival when compared to the longevity of the control group. The dose of 1,000 rads given twice was highly effective and the life-span of tumor-bearing rats increased from 72% to 121%. Misonidazole plus irradiation negated the prolongation of survival, achieved with radiation therapy alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390355
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Undifferentiated gliomas of the brain stem (1989)
    Springer
    Child's nervous system 5 (1989), S. 32-34 
    Details
    ISSN: 1433-0350
    Keywords: Undifferentiated brain-stem glioma ; Embryonal tumor ; Radiation therapy ; Intracranial biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Undifferentiated gliomas of the brain stem were confirmed surgically in two young children. The patients were treated by aggressive irradiation of the entire neuraxis, similar to that administered for medulloblastoma. Therapy resulted in a good prognosis and there was no tumor recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00706744
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Tissue edema and loss of tracer microspheres in infarcted myocardium (1983)
    Springer
    Basic research in cardiology 78 (1983), S. 124-130 
    Details
    ISSN: 1435-1803
    Keywords: myocardial infarction ; tissue edema ; tracer microspheres ; microsphere loss ; regional myocardial blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Microsphere loss from the ischemic myocardium was studied in a canine model after 2 and 7 days coronary occlusion. 10 million tracer microspheres (TM) of 7–10 μm diameter were injected into the left atrium before and 15 minutes after left anterior descending coronary artery (LAD) occlusion. To determine the tissue water content, dried tissue weight was measured after desiccation. TM content in the nonoccluded left circumflex coronary artery (LCX) area was unchanged before and after coronary occlusion. In the infarcted area, microsphere loss was maximum at the low flow endocardial region averaging 27% and 42% in 2 and 7 days occlusion, respectively. An inverse linear correlation between TM loss and regional blood flow in 2 (r=−0.82, p〈0.05) and 7 (r=−0.96, p〈0.01) days coronary occlusion was noted. Water content was increased in the ischemic endocardium by 4.1 and 5.7% in 2 and 7 days occlusion, thus approximately 17% of TM loss was attributed to tissue edema. These results suggest that there is an ischemia-dependent reduction of TM in the ischemic myocardium and that microsphere migration participates in the major part of TM loss. Thus flow measurements by TM may be invalid when this compound is injected during the active phase of microsphere migration or during water content alterations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01906666
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Linear relationship between perfusion area and infarct size (1981)
    Springer
    Basic research in cardiology 76 (1981), S. 438-442 
    Details
    ISSN: 1435-1803
    Keywords: perfusion area ; infarct size ; tracer microspheres ; autoradiography ; tetrazolium staining
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to develop a technique measuring the perfusion area of the coronary artery preocclusively and to study the relationship between the perfusion are aand infarct size.125I tracer microspheres were selectively injected into the left circumflex coronary artery (LCX) preocclusively, and then the LCX was ligated 48 hours later the heart was removed, rapidly frozen, and 50-μ transverse sections were obtained from base, middle and apex of the canine left ventricle, and used for autoradiography to measure perfusion area and for tetrazolium staining to measure infarct size. Dogs were divided into 2 groups: group 1 in which the main trunk of the LCX was occluded to produce large infarct (n=10) and group 2 in which the distal branch of the LCX was occluded to produce small infarct (n=10). There was a linear correlation between the perfused and infarcted area regardless of a size or location of the perfusion area involved. These results indicate that the extent of infarction is directly proportional to the perfusion area and is not altered by the location in the ventricle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01908338
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    Paper (German National Licenses)
    Fulltext
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