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  • 1
    Electronic Resource
    Electronic Resource
    Cloning and nucleotide sequence of cDNA for rhodopsin of the squid Todarodes pacificus
    Amsterdam : Elsevier
    FEBS Letters 317 (1993), S. 5-11 
    Details
    ISSN: 0014-5793
    Keywords: Retinal protein ; Retinal-binding protein ; Retinochrome ; Rhodopsin ; Todarodes pacificus ; Visual cell
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(93)81480-N
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Amino acid sequence surrounding the retinal-binding site in retinochrome of the squid, Todarodes pacificus
    Amsterdam : Elsevier
    FEBS Letters 335 (1993), S. 94-98 
    Details
    ISSN: 0014-5793
    Keywords: Photoisomerization ; Retinal-binding site ; Retinochrome ; Rhodopsin ; Todarodes pacificus ; Visual cell
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(93)80447-3
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Relation of clinical activity of rheumatoid arthritis to immune complexes, complement components and anti-immunoglobulins (1984)
    Springer
    Rheumatology international 4 (1984), S. 159-163 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Immune complexes ; Anti-immunoglobulin ; Complement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Circulating immune complexes by fluid phase Clq binding assay, complement components and anti-immunoglobulin levels were studied in sera of 35 patients with rheumatoid arthritis (RA). In 23 of the 35 sera (65.7%), circulating immune complexes were positive, and the mean±SD of Clq binding activity (ClqBA), 44.5±19.4%, was significantly high compared to that of healthy persons, 17.4±8.2%. Antigenic determination of complement components revealed that Clq, C3, C5, C9, factor B and Cl esterase inhibitor (CIINH) were significantly high in sera of RA, but C4 and properdin were not. The disease activity correlated with ClqBA, IgG- and IgM-anti-immunoglobulins, C9 and serum IgG. On the other hand, ClqBA correlated with both IgG- and IgM-anti-immunoglobulin levels but not with complement components.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541207
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    b3-adrenergic-receptor polymorphism: a genetic marker for visceral fat obesity and the insulin resistance syndrome (1997)
    Springer
    Diabetologia 40 (1997), S. 200-204 
    Details
    ISSN: 1432-0428
    Keywords: Keywordsβ3-adrenergic-receptor gene ; obesity ; insulin resistance syndrome ; genetics ; polymorphism.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated whether the polymorphism of the β 3-adrenergic receptor (β 3-AR) gene, which is associated with insulin resistance in non-diabetic subjects and an earlier onset of non-insulin-dependent diabetes mellitus in Pima Indians, was associated with visceral fat obesity and features of the insulin resistance syndrome in Japanese premenopausal obese women. There was no difference between 131 obese women and 256 control subjects (0.23 vs 0.17, p = 0.112) in the frequency of the Arg64 allele. The visceral fat area measured by computerised tomography scan was greater in homozygous Arg64Arg (172 ± 17 cm2, n = 6) and heterozygous Trp64Arg (178 ± 47 cm2, n = 48) women than in women homozygous for the Trp64Trp (121 ± 46 cm2, n = 77) genotype (p 〈 0.01). This was also reflected by increased total body fat but not by increased body mass index. The association between the Trp64 allele and visceral fat mass by multiple regression analysis, was independent of age, body mass index and total fat mass (p 〈 0.004). Moreover, homozygous carriers of the Arg64 allele had higher systolic blood pressure, higher fasting and post-load glucose and insulin concentrations, higher cholesterol, and triglyceride and lower HDL-cholesterol concentrations than homozygous carriers of the Trp64 allele. Some of these differences were also observed between heterozygous Trp64Arg and homozygous Trp64Trp genotypes (glucose tolerance, insulin and cholesterol concentration). We conclude that in obese women the β 3-AR polymorphism may be used as a genetic marker for visceral fat obesity and the insulin resistance syndrome. [Diabetologia (1997) 40: 200–204]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050663
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  • 5
    Electronic Resource
    Electronic Resource
    Quantification of bone volume on radiographs using NIH Image (2000)
    Springer
    Modern rheumatology 10 (2000), S. 220-224 
    Details
    ISSN: 1439-7609
    Keywords: Key words Radiograph ; Rheumatoid arthritis ; Bone volume ; NIH Image ; Computer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We attempted to quantify periarticular bone atrophy from radiographs of the proximal phalanx in patients with rheumatoid arthritis (RA) by means of the National Institutes of Health (NIH) Image computer program. The degree of brightness or darkness in four squares, each 20 × 20 pixels, in the right third proximal phalanx was measured using NIH Image, and the mean value of the 400 pixels was defined as the brightness/darkness index (BDI). The BDI was used to express bone volume. The BDI value was set at zero for an area of complete darkness and at 255 for an area of maximum brightness. The mean coefficient of variation in our hospital was 2.28%. The BDI was measured in 54 RA patients and 146 normal volunteers. The mean BDI at the midpoint of the diaphysis was 100 in RA patients and 176 in normal volunteers, while at the medial side of the proximal end it was 75 and 145, respectively. The difference between normal volunteers and RA patients was greatest in younger people. In some young RA patients, the BDI was significantly low at the medial side of the proximal end, clearly demonstrating periarticular bone atrophy. Periarticular bone atrophy can be quantified using the NIH Image computer program.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101650070006
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    Paper (German National Licenses)
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